US6762168B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Macrolide antiinfective agents
Assignee: Kosan Biosciences Inc
•
Filing: 2003-02-03
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Granted: 2004-07-13
•
Expires: 2023-02-03
Abstract
Abstract The invention is directed towards antibacterial compounds. The invention concerns macrolide antibiotics useful as antiinfective agents.
Inventors
- 👤 Daniel T. W. Chu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:43
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
138 words
A compound of the formula wherein R a is substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (3-20C); substituted or unsubstituted arylalkyl (4-20C); or OR a is replaced by H; R b is H or halogen; R c is H or a protecting group; R d is fluoroethyl R e is H or a protecting group; each of A, B, D and E is independently H, substituted or unsubstituted alkyl (1-10C) or wherein any pair of said A, B, D and E forms a 3-7 -membered ring optionally containing one or more heteroatoms, with the proviso that at least two of said A, B, D and E must be hydrogen; or a pharmaceutically acceptable salt thereof or a stereoisomeric form or a mixture of stereoisomeric forms thereof.
Claim 2
Dependent Claim
138 words
A compound of the formula wherein R a is substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (3-20C); substituted or unsubstituted arylalkyl (4-20C); or OR a is replaced by H; R b is H or halogen; R c is H or a protecting group; R d is fluoroethyl R e is H or a protecting group; each of A, B, D and E is independently H, substituted or unsubstituted alkyl (1-10C) or wherein any pair of said A, B, D and E forms a 3-7 -membered ring optionally containing one or more heteroatoms, with the proviso that at least two of said A, B, D and E must be hydrogen; or a pharmaceutically acceptable salt thereof or a stereoisomeric form or a mixture of stereoisomeric forms thereof.
Claim 3
Dependent Claim
12 words
The compound of claim 1 wherein R a is arylalkenyl or arylalkynyl.
Claim 4
Dependent Claim
14 words
The compound of claim 2 wherein R a is 3-aryl prop-2-enyl or 3-aryl prop-2-ynyl.
Claim 5
Dependent Claim
22 words
The compound of claim 3 wherein said aryl is 3-quinolyl, 4-quinolyl or 5-quinolyl, phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, 6-quinolyl, 6-quinoxalyl, 6-amino-3-quinolyl, or 4-isoquinolyl.
Claim 6
Dependent Claim
14 words
The compound of claim 1 wherein R a is H or lower C1-C3 alkyl.
Claim 7
Dependent Claim
10 words
The compound of claim 5 wherein R a is methyl.
Claim 8
Dependent Claim
10 words
The compound of claim 1 wherein R b is fluoro.
Claim 9
Dependent Claim
16 words
A pharmaceutical composition comprising the compound of claim 1 in admixture with a pharmaceutically acceptable excipient.
Claim 10
Dependent Claim
36 words
A method to control a bacterial infection in a subject which method comprises administering to a subject in need of such control an effective amount of the compound of claim 1 or a pharmaceutical composition thereof.
Claim 11
Dependent Claim
25 words
A method to preserve material from microbial decay which method comprises providing said material with an effective amount of the compound of claim 1 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2007-07-13 | 2008-01-12 | 2008-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-07-13 | 2012-01-12 | 2012-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-07-13 | 2016-01-12 | 2016-07-13 | $7700.00 | Window Closed / Lapsed |