US5141926A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Erythromycin derivatives
Assignee: Abbott Laboratories
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Filing: 1990-04-18
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Granted: 1992-08-25
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Expires: 2010-04-18
Abstract
Abstract Novel 6-deoxyerythromycin derivatives are disclosed, as are methods for their preparation and use as antiinfective agents. The compounds of the invention include 6-deoxyerythromycins and 6-deoxy-15-norerythromycins which are represented by the structural formula ##STR1## in which R 1 is selected from OH and H, and R 2 and R 3 are independently selected from H and CH 3 , as well as the pharmaceutically acceptable salts and esters of the above compounds. Additionally disclosed are genetically modified microorganisms which produce the compounds of the invention and means for the preparation of those microorganisms.
Inventors
- 👤 J. Mark Weber
- 👤 James B. McAlpine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:36
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P31/00; A61P31/04; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/52; C12P; C12P19/00; C12P19/44; C12P19/60; C12P19/62; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/882
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
46 words
A compound having the formula: ##STR4## wherein R 1 is selected from the group consisting of OH and H, and R 2 and R 3 are independently selected from the group consisting of H and CH 3 , or a pharmaceutically acceptable salt or ester thereof.
Claim 2
Dependent Claim
46 words
A compound having the formula: ##STR4## wherein R 1 is selected from the group consisting of OH and H, and R 2 and R 3 are independently selected from the group consisting of H and CH 3 , or a pharmaceutically acceptable salt or ester thereof.
Claim 3
Dependent Claim
28 words
A compound selected from the group consisting of 6-deoxyerythromycins A, B, C and D, 6-deoxy-15-noreythromycins A, B, C and D, and the pharmaceutically acceptable salts and esters thereof.
Claim 4
Dependent Claim
28 words
A compound selected from the group consisting of 6-deoxyerythromycins A, B, C and D, 6-deoxy-15-noreythromycins A, B, C and D, and the pharmaceutically acceptable salts and esters thereof.
Claim 5
Dependent Claim
47 words
A fermentation isolate obtained by culturing a microorganism, comprising a compound having the formula: ##STR5## wherein R 1 is selected from the group consisting of OH and H, and R 2 and R 3 are independently selected from the group consisting of H and CH 3 .
Claim 6
Dependent Claim
47 words
A fermentation isolate obtained by culturing a microorganism, comprising a compound having the formula: ##STR5## wherein R 1 is selected from the group consisting of OH and H, and R 2 and R 3 are independently selected from the group consisting of H and CH 3 .
Claim 7
Dependent Claim
29 words
The fermentation isolate of claim 3 wherein the compound is selected from the group consisting of 6-deoxyerythromycins A, B, C and D and 6-deoxy-15-norerythromycins A, B, C and D.
Claim 8
Dependent Claim
21 words
A pharmaceutical composition comprising a thereapeutically effective amount of a compound according to claim 1 in combination with a pharmaceutical carrier.
Claim 9
Dependent Claim
29 words
A method of treating bacterial infections in a patient in need of such treatment, comprising administering to the patient a thereapeutically effective amount of a compound of claim 1.
References Cited (Backward Citations)
US4331803A
Cited
US4874748A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-25 | 1996-02-24 | 1996-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-25 | 2000-02-24 | 2000-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-25 | 2004-02-24 | 2004-08-25 | $7700.00 | Window Closed / Lapsed |