US6121432A
Expired / Lapsed
US
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Erythromycins
Assignee: Aventis Pharma SA
•
Filing: 1999-03-22
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Granted: 2000-09-19
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Expires: 2019-03-22
Abstract
Abstract Novel compounds of the formula ##STR1## wherein A is --OH and B forms with the 10-carbon a carbon--carbon double bond or A and B together form a carbonate or a carbamate, --OZ is selected from the group consisting of --OH, etherified hydroxy or esterified hydroxy and its non-toxic, pharmaceutically acceptable acid addition salts.
Inventors
- 👤 Alain Bonnet
- 👤 Francoise Gambier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:37
CPC Classifications
C; C07; C07D; C07D313/00; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
47 words
A compound selected from the group consisting of a compound of the formula ##STR10## wherein A is --OH and B forms with the 10-carbon a carbon--carbon double bond or A and B together form a carbonate, Z is trimethylsilyl and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 2
Dependent Claim
47 words
A compound selected from the group consisting of a compound of the formula ##STR10## wherein A is --OH and B forms with the 10-carbon a carbon--carbon double bond or A and B together form a carbonate, Z is trimethylsilyl and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 3
Dependent Claim
29 words
A compound having the formula ##STR11## wherein --OZ is selected from the group consisting of --OH, etherified hydroxy or esterified hydroxy and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
29 words
A compound having the formula ##STR11## wherein --OZ is selected from the group consisting of --OH, etherified hydroxy or esterified hydroxy and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
17 words
A compound of claim 1 having the formula ##STR12## wherein Z is defined as in claim 2.
Claim 6
Dependent Claim
96 words
A process for the preparation of a compound of the formula ##STR13## wherein A and B are as defined in claim 1 and --OZ is selected from the group consisting of --OH, etherified hydroxy or esterified hydroxy and its non-toxic, pharmaceutically acceptable acid addition salts comprising reacting a compound of claim 1 with carbonyldiimidazole to obtain a compound of the formula ##STR14## reacting the latter with an amine of the formula H 2 NR wherein R is alkyl of 1 to 6 carbon atoms to obtain the compound of formula III and optionally releasing the 2'-hydroxyl.
Claim 7
Dependent Claim
14 words
A compound of the formula ##STR15## wherein --OZ is defined as in claim 2.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-09-19 | 2004-03-20 | 2004-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-09-19 | 2008-03-20 | 2008-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-09-19 | 2012-03-20 | 2012-09-19 | $7700.00 | Window Closed / Lapsed |