US4742049A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Semisynthetic erythromycin antibiotics
Assignee: Abbott Laboratories
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Filing: 1986-06-04
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Granted: 1988-05-03
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Expires: 2006-06-04
Abstract
Abstract Semisynthetic antibiotics with improved therapeutic properties made from erythromycin are disclosed. 11,12-Cyclic carbamates of erythromycin, its derivatives, and their salts and esters show superior in vitro antimicrobial activity and reduced hepatotoxicity compared to the parent compounds.
Inventors
- 👤 William R. Baker
- 👤 Jerry D. Clark
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:39
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
42 words
A compound of the formula ##STR3## where R 1 is selected from hydroxyl or O-acyl of 2 to 20 carbon atoms, R 2 is hydrogen or methyl and R 3 is hydrogen, alkyl, alkoxy, dimethylaminoalkyl, or haloalkyl, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
42 words
A compound of the formula ##STR3## where R 1 is selected from hydroxyl or O-acyl of 2 to 20 carbon atoms, R 2 is hydrogen or methyl and R 3 is hydrogen, alkyl, alkoxy, dimethylaminoalkyl, or haloalkyl, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 wherein R 2 is methyl.
Claim 4
Dependent Claim
16 words
A compound according to claim 2 wherein R 1 is hydroxyl and R 3 is 2-dimethylaminoethyl.
Claim 5
Dependent Claim
25 words
An antibacterial composition in unit dosage form, comprising an antibacterially effective amount of a compound according to claim 1 in combination with a pharmaceutical carrier.
Claim 6
Dependent Claim
36 words
A method of treating and preventing bacterial infections in humans and lower animals in need of such treatment, comprising administering to the human or lower animal a therapeutically effective amount of the composition of claim 4.
References Cited (Backward Citations)
JPS5259086A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-03 | 1991-11-02 | 1992-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-03 | 1995-11-02 | 1996-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-03 | 1999-11-02 | 2000-05-03 | $7700.00 | Window Closed / Lapsed |