5-O-desosaminylerythronolide derivatives

Claim 1

A 5-0-desosaminylerythronolide derivative represented by the formula: ##STR37## wherein: Y is a group represented by the formula: ##STR38## (wherein R 1 is a hydrogen atom, a hydroxyl group, a halogen atom, a C 1 -C 3 alkyl group or an amino group, and n is an integer of 0 to 4), an oxygen atom, a vinylene group, or a group represented by the formula --CH 2 --NH--CO, R is a C 7 -C 15 aralkyl group; a C 7 -C 15 aralkyl group substituted by at least one member selected from the group consisting of a nitro group, a methoxy group, a methoxythio group, a methoxycarbonyl group, a carboxy group, a methylene group, a halogen atom, a trifluoromethyl group, an amino group and a demethylamino group; a phenyl group; a phenyl group having 1 to 5 substituents selected from the group consisting of halogen atoms, nitro groups, amino groups, C 1 -C 3 alkyl groups, C 1 -C 3 alkyl groups substituted by one or more halogen atoms, C 1 -C 4 alkylamino groups, C 2 -C 7 acylamino groups and C 1 -C 4 alkoxy groups; a naphthyl group; a thiazolyl group; an imidazolyl group; an amino-thiazolyl group; a biphenyl group; a thienyl group; a pyridyl group; a pyridyl group substituted by one or more nitro groups; a phenylthio group; a phenyloxy group substituted by one or more halogen atoms or nitro groups; or an indolyl group, A is a group represented by: the formula (i): ##STR39## wherein Z is an oxygen atom or a group represented by the formula ═N--O--R 4 (wherein R 4 is a hydrogen atom; a C 1 -C 8 alkyl group; --CH 2 CH 2 OCH 3 ; --CH 2 CH 2 OCH 2 CH 2 OCH 3 ; --CH 2 CH 2 OCH 2 CH 2 OCH 2 CH 2 OCH 3 ; --CH 2 CH 2 CH 2 OCH 3 ; --CH 2 CH 2 SCH 3 ; --CH 2 CH 2 (NH)CH 2 CH 2 N(CH 3 ) 2 ; --CH 2 OCH 2 CH 2 OCH 3 ; --CH 2 CH 2 N(CH 3 ) 2 ; --CH 2 CH 2 N(CH 2 )(CH 2 Ph; a benzyl group; or a benzyl group having 1 to 5 substituents selected from the group consisting of halogen atoms and C 1 -C 4 alkyl groups), V is a hydroxyl group and W is a hydrogen atom or a hydroxyl group, or V and W represent, together with the carbon atoms at the 11- and 12-positions, a group represented by the formula: ##STR40## a group represented by the formula: ##STR41## (wherein R 5 is a hydrogen atom or a C 1 -C 3 alkyl group), a group represented by the formula (ii): ##STR42## (wherein R 6 is a hydrogen atom or a C 1 -C 3 alkyl group), or a group represented by the formula (iii): ##STR43## (wherein R 7 is a hydrogen atom, a C 1 -C 4 alkyl group, a C 3 -C 5 alkenyl group or C 3 -C 5 alkynyl group, and V and W are as defined above), R' is a hydrogen atom, a C 1 -C 5 alkyl group, a carbamoyl group or an acetyl group, R" is a hydrogen atom, a C 2 -C 15 alkoxycarbonyl group, 2-[2-(2-methoxyethyoxy) ethoxy]ethoxycarbonyl group, 2-[2-(2-ethoxyethoxy)ethoxy]ethoxycarbonyl group, a C 2 -C 15 acyl group, an ethylsuccinyl group, or a pyridylcarbonyl group or a pharmaceutically acceptable acid addition salt thereof.