US6716208B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable device and use therefor
Assignee: RENAMED BIOLOGICS Inc
•
Filing: 2000-12-12
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Granted: 2004-04-06
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Expires: 2020-12-12
Abstract
Abstract Disclosed is an implantable device for delivering a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation. The device comprises a blood permeable element that can be anchored to an inner wall of an intact blood vessel. The device also comprises a capsule that is held in place within the blood vessel by the anchored blood permeable element. The capsule encloses viable cells which produce and secrete the pre-selected molecule into blood passing the capsule. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel the device of the invention.
Inventors
- 👤 H. David Humes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:41
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61F; A61F2/00; A61F2/01; A61F2/0105; A61F2/02; A61F2/022; A61M; A61M31/00; A61M31/002; A61F2002/016; A61F2230/00; A61F2230/0002; A61F2230/0028; A61F2230/005; A61F2230/0063; A61F2230/0067; A61K38/00
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
88 words
An implantable intravascular device comprising in combination: (a) a blood clot anti-migration filter anchorable to an inner wall of a blood vessel, which when anchored to the inner wall of the vessel permits blood in the vessel to pass therethrough; and (b) a capsule defining a plurality of pores and having viable cells disposed therein, wherein the capsule, when introduced into the vessel, is retained within the vessel by the filter and the pores permit nutrients to enter the capsule to maintain viability of the cells disposed therein.
Claim 2
Dependent Claim
88 words
An implantable intravascular device comprising in combination: (a) a blood clot anti-migration filter anchorable to an inner wall of a blood vessel, which when anchored to the inner wall of the vessel permits blood in the vessel to pass therethrough; and (b) a capsule defining a plurality of pores and having viable cells disposed therein, wherein the capsule, when introduced into the vessel, is retained within the vessel by the filter and the pores permit nutrients to enter the capsule to maintain viability of the cells disposed therein.
Claim 3
Dependent Claim
14 words
The device of claim 1 , wherein the filter comprises a plurality of filaments.
Claim 4
Dependent Claim
11 words
The device of claim 2 , wherein the filaments are metallic.
Claim 5
Dependent Claim
15 words
The device of claim 1 , wherein the capsule is defined by a semi-permeable membrane.
Claim 6
Dependent Claim
47 words
The device of claim 4 , wherein the semi-permeable membrane comprises a material selected from the group consisting of polyvinylchloride, polyvinylidene fluoride, polyurethane isocyanate, polyalginate, cellulose acetate, cellulose diacetate, cellulose triacetate, cellulose nitrate, polysulfone, polystyrene, polyurethane, polyvinyl alcohol, polyacrylonitrile, polyamide, polymethylmethacrylate, polyethylene oxide, polytetrafluorethylene, and mixtures thereof.
Claim 7
Dependent Claim
24 words
The device of claim 1 , wherein the pores are dimensioned to exclude an agent in the blood which is detrimental to cell viability.
Claim 8
Dependent Claim
17 words
The device of claim 6 , wherein the pores are dimensioned to prevent passage of antibodies tberethrougb.
Claim 9
Dependent Claim
12 words
The device of claim 1 , wherein the cells are eukaryotic cells.
Claim 10
Dependent Claim
12 words
The device of claim 8 , wherein the cells are mammalian cells.
Claim 11
Dependent Claim
20 words
The device of claim 1 , wherein the capsule when introduced into the vessel is retained upstream of the filter.
Claim 12
Dependent Claim
15 words
The device of claim 1 , wherein the capsule comprises at least one hollow fiber.
Claim 13
Dependent Claim
18 words
The device of claim 1 , wherein the pores permit solutes less than 150 kD to pass therethrough.
Claim 14
Dependent Claim
13 words
The device of claim 1 , wherein the cells are genetically engineered cells.
Claim 15
Dependent Claim
99 words
An implantable intravascular device comprising in combination: (a) a blood clot anti-migration filter comprising a head and a plurality of legs extending therefrom anchorable to an inner wall of a blood vessel, which when anchored to the inner wall of the blood vessel permits blood in the vessel to pass therethrough; and (b) a capsule defining a plurality of pores and having viable cells disposed therein, wherein the capsule, when introduced into the vessel, is retained within the vessel by the filter and the pores permit nutrients to enter the capsule to maintain viability of the cells disposed therein.
Claim 16
Dependent Claim
99 words
An implantable intravascular device comprising in combination: (a) a blood clot anti-migration filter comprising a head and a plurality of legs extending therefrom anchorable to an inner wall of a blood vessel, which when anchored to the inner wall of the blood vessel permits blood in the vessel to pass therethrough; and (b) a capsule defining a plurality of pores and having viable cells disposed therein, wherein the capsule, when introduced into the vessel, is retained within the vessel by the filter and the pores permit nutrients to enter the capsule to maintain viability of the cells disposed therein.
Claim 17
Dependent Claim
15 words
The device of claim 14 , wherein the capsule is defined by a semi-permeable membrane.
Claim 18
Dependent Claim
47 words
The device of claim 15 , wherein the semi-permeable membrane comprises a material selected from the group consisting of polyvinylchloride, polyvinylidene fluoride, polyurethane isocyanate, polyalginate, cellulose acetate, cellulose diacetate, cellulose triacetate, cellulose nitrate, polysulfone, polystyrene, polyurethane, polyvinyl alcohol, polyacrylonitrile, polyimide, polymethylmethacrylate, polyethylene oxide, polytetrafluorethylene, and mixtures thereof.
Claim 19
Dependent Claim
24 words
The device of claim 14 , wherein the pores are dimensioned to exclude an agent in the blood which is detrimental to cell viability.
Claim 20
Dependent Claim
17 words
The device of claim 17 , wherein the pores are dimensioned to prevent passage of antibodies therethrough.
Claim 21
Dependent Claim
12 words
The device of claim 14 , wherein the cells are eukaryotic cells.
Claim 22
Dependent Claim
13 words
The device of claim 19 , wherein in the cells are mammalian cells.
Claim 23
Dependent Claim
11 words
The device of claim 14 , wherein the filter is metallic.
Claim 24
Dependent Claim
20 words
The device of claim 14 , wherein the capsule when introduced into the vessel is retained upstream of the filter.
Claim 25
Dependent Claim
15 words
The device of claim 14 , wherein the capsule comprises at least one hollow fiber.
Claim 26
Dependent Claim
18 words
The device of claim 14 , wherein the pores permit solutes less than 150 kD to pass therethrough.
Claim 27
Dependent Claim
13 words
The device of claim 14 , wherein the cells are genetically engineered cells.
Claim 28
Independent Claim
108 words
A method of introducing an implantable intravascular device into a blood vessel of a mammal, the method comprising the steps of: (a) anchoring a blood clot anti-migration filter to an inner wall of a blood vessel of the mammal, which when anchored to the inner wall of the vessel permits blood in the vessel to pass therethrough; and (b) introducing into the vessel a capsule defining a plurality of pores and having viable cells disposed therein, such that when introduced, the capsule is retained within the vessel by the filter and the pores permit nutrients to enter the capsule to maintain the viability of the cells disposed therein.
Claim 29
Independent Claim
108 words
A method of introducing an implantable intravascular device into a blood vessel of a mammal, the method comprising the steps of: (a) anchoring a blood clot anti-migration filter to an inner wall of a blood vessel of the mammal, which when anchored to the inner wall of the vessel permits blood in the vessel to pass therethrough; and (b) introducing into the vessel a capsule defining a plurality of pores and having viable cells disposed therein, such that when introduced, the capsule is retained within the vessel by the filter and the pores permit nutrients to enter the capsule to maintain the viability of the cells disposed therein.
Claim 30
Dependent Claim
20 words
The method of claim 26 , wherein in step (a), the filter is introduced into the vessel via a catheter.
Claim 31
Dependent Claim
20 words
The method of claim 26 , wherein in step (b), the capsule is introduced into the vessel via a catheter.
Claim 32
Dependent Claim
12 words
The method of claim 26 , wherein the vessel is a vein.
Claim 33
Dependent Claim
14 words
The method of claim 26 , wherein the filter comprises at least one filament.
Claim 34
Dependent Claim
19 words
The method of claim 26 , wherein the filter comprises a head and a plurality of legs extending therefrom.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2007-04-06 | 2007-10-06 | 2008-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-04-06 | 2011-10-06 | 2012-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-04-06 | 2015-10-06 | 2016-04-06 | $7700.00 | Window Closed / Lapsed |