US6596296B1
Expired / Lapsed
US
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Drug releasing biodegradable fiber implant
Assignee: The University of Texas System
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Filing: 2000-08-04
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Granted: 2003-07-22
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Expires: 2020-08-04
Abstract
Abstract The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.
Inventors
- 👤 Kevin D. Nelson
- 👤 Andres A. Romero-Sanchez
- 👤 George M. Smith
- 👤 Nadir Alikacem
- 👤 Delia Radulescu
- 👤 Paula Waggoner
- 👤 Zhibing Hu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 08:35
CPC Classifications
D; D01; D01F; D01F1/00; D01F1/02; D01F1/10; A; A61; A61K; A61K9/00; A61K9/70; A61L; A61L27/00; A61L27/50; A61L27/54; A61L27/58; A61P; A61P35/00; A61P37/00; A61P37/02; A61P43/00; A61P7/00; D01F6/00; D01F6/58; D01F6/62; D01F6/625; D01F8/00; D01F8/04; D01F8/14; D06; D06M; D06M15/00; D06M15/01; D06M15/03; D06M16/00; A61B; A61B17/00; A61B17/11; A61B17/1128; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/0048; A61K9/0051; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/258; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/426; A61L2300/60; A61L2300/602; A61L2300/604; Y; Y10; Y10T; Y10T428/00; Y10T428/30; Y10T442/00; Y10T442/20; Y10T442/2525
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
40 words
A composition comprising at least one biodegradable polymer fiber wherein said fiber is composed of a first phase and a second phase, the first and second phases being immiscible, and wherein the second phase comprises one or more therapeutic agents.
Claim 2
Dependent Claim
40 words
A composition comprising at least one biodegradable polymer fiber wherein said fiber is composed of a first phase and a second phase, the first and second phases being immiscible, and wherein the second phase comprises one or more therapeutic agents.
Claim 3
Dependent Claim
20 words
The composition of claim 1 , wherein said second phase is derived from an aqueous solution, a hydrogel or polymer.
Claim 4
Dependent Claim
29 words
The composition of claim 1 , wherein said fiber forms a scaffold and further wherein, said second phase is manipulated to form an internal porous structure within the fiber.
Claim 5
Dependent Claim
34 words
The composition of claim 1 , wherein said fiber is woven, braided or knitted in an assembly with other fibers, and at least one fiber in the assembly comprises one or more therapeutic agents.
Claim 6
Dependent Claim
23 words
The composition of claim 1 , wherein the one or more therapeutic agents are distributed within the second phase in a nonhomogenous pattern.
Claim 7
Dependent Claim
24 words
The composition of claim 1 , wherein the concentration of said one or more therapeutic agents varies along the longitudinal axis of the fiber.
Claim 8
Dependent Claim
36 words
The composition of claim 6 , wherein the concentration of said one or more therapeutic agents varies linearly, exponentially or in any desired fashion, as a function of distance along the longitudinal axis of the fiber.
Claim 9
Dependent Claim
31 words
The composition of claim 1 , wherein the concentration of said one or more therapeutic agents decreases from a first end of the fiber to a second end of the fiber.
Claim 10
Dependent Claim
49 words
The composition of claim 1 , wherein said one or more therapeutic agents vary in a bidirectional manner, and the content of said one or more therapeutic agents increases from the first end of said fiber to a maximum and then decreases towards the second end of said fiber.
Claim 11
Dependent Claim
18 words
The composition of claim 1 , further comprising at least one biodegradable polymer fiber containing no therapeutic agent.
Claim 12
Dependent Claim
53 words
The composition of claim 1 , wherein said one or more therapeutic agents are selected from the group consisting of drugs, proteins, enzymes, growth factors, immunomodulators, compounds promoting angiogenesis, compounds inhibiting angiogenesis, anti-inflammatory compounds, antibiotics, cytokines, anti-coagulation agents, procoagulation agents, chemotactic agents, agents to promote apoptosis, agents to inhibit apoptosis, and mitogenic agents.
Claim 13
Dependent Claim
24 words
The composition of claim 1 , wherein said one or more therapeutic agents include a radioactive agent or a contrast agent for imaging studies.
Claim 14
Dependent Claim
25 words
The composition of claim 1 , wherein said one or more therapeutic agents is selected from the group consisting of viral vector, polynucleotide and polypeptide.
Claim 15
Dependent Claim
17 words
The composition of claim 1 , wherein said one or more therapeutic agents comprise an angiogenesis-promoting agent.
Claim 16
Dependent Claim
15 words
The composition of claim 14 , wherein said angiogenesis-promoting agent is vascular endothelial growth factor.
Claim 17
Dependent Claim
45 words
The composition of claim 1 , wherein said biodegradable polymer is a single polymer, a co-polymer, or a mixture of polymers selected from the group consisting of polypeptides, polydepsipeptides, nylon copolyamides, aliphatic polyesters, polydihydropyrans, polyphosphazenes, poly(ortho ester), poly(cyano acrylates), polyanhydride, modified polysaccharides and modified proteins.
Claim 18
Dependent Claim
33 words
The composition of claim 16 , wherein said aliphatic polyesters are selected from the group consisting of poly(glycolic acid), poly(lactic acid), poly(alkylene succinates) poly(hydroxybutyrate), poly(butylene diglycolate), poly(epsilon-caprolactone) and copolymers, blends and mixtures thereof.
Claim 19
Dependent Claim
35 words
The composition of claim 16 , wherein said modified polysaccharides are selected from the group consisting of cellulose, starch-alginate and the glycosaminoglycans, chondroitin sulfate, heparin, heparin sulfate, dextran, dextran sulfate, chitin, chitosan and chitosan sulfate.
Claim 20
Dependent Claim
20 words
The composition of claim 16 , wherein said modified proteins are selected from the group consisting of collagen and fibrin.
Claim 21
Dependent Claim
24 words
The composition of claim 1 , wherein said fiber comprises a plurality of polymer layers, wherein an outer layer circumscribes an adjacent inner layer.
Claim 22
Dependent Claim
18 words
The composition of claim 20 , wherein said plurality of layers optionally contain one or more therapeutic agents.
Claim 23
Dependent Claim
22 words
The composition of claim 21 , wherein said one or more therapeutic agents are released over time from said plurality of layers.
Claim 24
Dependent Claim
18 words
The composition of claim 1 , wherein the fiber contains more than one therapeutic agent along its length.
Claim 25
Dependent Claim
25 words
The composition of claim 23 , wherein the concentration of said more than one therapeutic agent varies along the length of said subset of fibers.
Claim 26
Dependent Claim
23 words
The composition of claim 23 , wherein said more than one therapeutic agents are released at varying rates over time from said fiber.
Claim 27
Dependent Claim
23 words
The composition of claim 1 , wherein said one or more therapeutic agents are released at varying rates over time from said fiber.
Claim 28
Dependent Claim
31 words
A composition comprising a three-dimensional scaffold, said scaffold comprising fibers that are woven, non-woven, or knitted, or braided, wherein said fibers comprise fibers containing chitosan or a reconstituted extracellular matrix composition.
Claim 29
Dependent Claim
31 words
A composition comprising a three-dimensional scaffold, said scaffold comprising fibers that are woven, non-woven, or knitted, or braided, wherein said fibers comprise fibers containing chitosan or a reconstituted extracellular matrix composition.
Claim 30
Dependent Claim
12 words
The composition of claim 27 , wherein said chitosan is sulfated chitosan.
Claim 31
Dependent Claim
14 words
A composition comprising fibers containing chitosan, reconstituted extracellular matrix composition and a therapeutic agent.
Claim 32
Dependent Claim
14 words
A composition comprising fibers containing chitosan, reconstituted extracellular matrix composition and a therapeutic agent.
Claim 33
Dependent Claim
12 words
The composition of claim 29 , wherein said chitosan is sulfated chitosan.
Claim 34
Dependent Claim
24 words
The composition of claim 21 , wherein said one or more therapeutic agents are distributed within the plurality of layers in a nonhomogenous pattern.
Claim 35
Dependent Claim
34 words
The composition of claim 31 , wherein the concentration of said one or more therapeutic agents varies linearly, exponentially or in any desired fashion, as a function of distance within the plurality of layers.
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