US4965128A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable polymer substrates loaded with active substance suitable for the controlled release of the active substance by means of a membrane
Assignee: Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
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Filing: 1988-02-26
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Granted: 1990-10-23
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Expires: 2008-02-26
Abstract
Abstract Biodegradable hollow fibres with an asymmetric wall, the cavity of which containing an active substance like a drug, hormone etc. or a dilute form of the latter and both ends of the hollow fibre being closed for the controlled release of the active substance as well as a process for the manufacturing of such hollow fibres.
Inventors
- 👤 Pieter J. Greidanus
- 👤 Jan Feijen
- 👤 Marinus J. D. Eenink
- 👤 Johannes C. Rieke
- 👤 Jan Olijslager
- 👤 Jan H. M. Albers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:45
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0092; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2927; Y10T428/2933; Y10T428/2935; Y10T428/2973; Y10T428/2975
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
95 words
Biodegradable polymer substrate loaded with an active substance selected from the group consisting of drugs, hormones, insecticides, feromones and repellants for the controlled release of the active substance wherein the substrate consists of a hollow fibre having an asymmetric wall formed from a biodegradable polymer selected from the group consisting of polyhydroxy acids and poly(-amino acids) and copolymers thereof by a coagulation technique, said hollow fibre having two ends and having a hollow cavity therewithin, the hollow cavity of the hollow fibre containing the active substance and the ends of the hollow fibre being closed.
Claim 2
Dependent Claim
95 words
Biodegradable polymer substrate loaded with an active substance selected from the group consisting of drugs, hormones, insecticides, feromones and repellants for the controlled release of the active substance wherein the substrate consists of a hollow fibre having an asymmetric wall formed from a biodegradable polymer selected from the group consisting of polyhydroxy acids and poly(-amino acids) and copolymers thereof by a coagulation technique, said hollow fibre having two ends and having a hollow cavity therewithin, the hollow cavity of the hollow fibre containing the active substance and the ends of the hollow fibre being closed.
Claim 3
Dependent Claim
36 words
Polymer substrate according to claim 1, characterised in that the biodegradable polymer is selected from polylactic acid, polyglycolic acid, poly(β-hydroxybutyrate), poly(hydroxyvalerate), poly(ε-caprolactone) or a copolymer derived therefrom and a polyglutamic acid or a copolymer derived therefrom.
Claim 4
Dependent Claim
15 words
Polymer substrate according to claim 2, characterised in that the biodegradable polymer is poly-lactic acid.
Claim 5
Dependent Claim
15 words
Polymer substrate according to claim 2, characterised in that the biodegradable polymer is poly-γ- ethyl-L-glutamate-co-γ-piperonyl-L-glutamate.
Claim 6
Dependent Claim
30 words
Polymer substrate according to claim 1, characterised in that the external diameter of the hollow fibre is 1.3 mm max. and the length of the hollow fibre is 1-2 cm.
Claim 7
Dependent Claim
30 words
Polymer substrate according to claim 1, characterised in that the external diameter of the hollow fibre is 3 mm max. and the length of the hollow fibre is 2-5 cm.
Claim 8
Dependent Claim
63 words
Biodegradable polymer substrate for used for the controlled release of an active substance selected from the group consisting of drugs, hormones, insecticides, feromones and repellants introduced therein, wherein the polymer substrate consists of an hollow fibre having an asymmetric wall formed from a biodegradable polymer selected from the group consisting of polyhydroxy acids and poly(-amino acids) and copolymers thereof by a coagulation technique.
Claim 9
Dependent Claim
63 words
Biodegradable polymer substrate for used for the controlled release of an active substance selected from the group consisting of drugs, hormones, insecticides, feromones and repellants introduced therein, wherein the polymer substrate consists of an hollow fibre having an asymmetric wall formed from a biodegradable polymer selected from the group consisting of polyhydroxy acids and poly(-amino acids) and copolymers thereof by a coagulation technique.
Claim 10
Dependent Claim
36 words
Polymer substrate according to claim 7, characterised in that the biodegradable polymer is selected from poly-lactic acid, polyglycolic acid, poly(β-hydroxybutyrate), poly(hydroxyvalerate), poly(ε-caprolactone) or a copolymer derived therefrom and a polyglutamic acid or a copolymer derived therefrom.
Claim 11
Dependent Claim
15 words
Polymer substrate according to claim 8, characterised in that the biodegradable polymer is polylactic acid.
Claim 12
Dependent Claim
14 words
Polymer substrate according to claim 8, characterised in that the biodegradable polymer is poly-γ-ethyl-L-glutamate-co-γ-piperonyl-L-glutamate.
References Cited (Backward Citations)
US4135514A
Cited
US4231877A
Cited
US4214020A
Cited
US4440853A
Cited
EP0061192A1
Cited
US4464321A
Cited
US4460641A
Cited
EP0126827A1
Cited
US4595583A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-22 | 1994-04-23 | 1994-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-22 | 1998-04-23 | 1998-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-22 | 2002-04-23 | 2002-10-23 | $7700.00 | Window Closed / Lapsed |