Patent US6544249B1 successfully refreshed from Google Patents.
US6544249B1
Expired / Lapsed
US
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Biological microfistula tube and implantation method and apparatus
Assignee: Lions Eye Institute
•
Filing: 1997-11-28
•
Granted: 2003-04-08
•
Expires: 2017-11-28
Abstract
Abstract The present invention provides a microfistula tube including a soluble duct, defining a drainage canal having an inner surface, the duct being biocompatible, wherein the microfistula tube is coated with and/or incorporates biological for forming a basement membrane, or an intracellular matrix and a basement membrane. The biological cells may coat the inner surface of the drainage canal, and the microfistula tube may be made of a mouldable material or an absorbable material. The invention also provides an implantation system for the microfistula tube including a microfistula tube and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein the outer tube, the inner tube and the innermost rod are coaxial, the outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube.
Inventors
- 👤 Dao-Yi Yu
- 👤 William Huxley Morgan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 21:37
CPC Classifications
A; A61; A61F; A61F9/00; A61F9/007; A61F9/00781; A61L; A61L31/00; A61L31/005; A61L31/04; A61L31/043; A61L31/044; A61M; A61M27/00
Claims Analysis
Total Claims: 89
Claim 1
Independent Claim
101 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said microfistula tube is made of absorbable material.
Claim 2
Dependent Claim
101 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said microfistula tube is made of absorbable material.
Claim 3
Dependent Claim
20 words
The microfistula tube as claimed in claim 1 wherein the biological cells coat the inner surface of the drainage canal.
Claim 4
Dependent Claim
18 words
The microfistula tube as claimed in claim 1 wherein the microfistula tube is made of a mouldable material.
Claim 5
Dependent Claim
18 words
The microfistula tube as claimed in claim 1 wherein the biological cells are endothelial or trabecular meshwork cells.
Claim 6
Dependent Claim
18 words
The microfistula tube as claimed in claim 1 wherein the microfistula tube is made of gelatin or collagen.
Claim 7
Dependent Claim
23 words
The microfistula tube as claimed in claim 1 wherein the microfistula tube is sufficiently rigid to allow ready insertion into a living body.
Claim 8
Dependent Claim
29 words
The microfistula tube as claimed in claim 1 wherein the circumferential outer surface of the microfistula tube tapers towards its forward end to facilitate its insertion into body tissues.
Claim 9
Dependent Claim
28 words
The microfistula tube as claimed in claim 1 wherein the soluble tube is provided with one or more generally rearwardly projecting barbs or a generally rearwardly projecting skirt.
Claim 10
Dependent Claim
26 words
The microfistula tube as claimed in claim 8 wherein said one or more barbs or said skirt is near the forward end of said microfistula tube.
Claim 11
Dependent Claim
45 words
The microfistula tube as claimed in claim 1 wherein the microfistula tube is adapted to form a passage from the anterior chamber to Schlemm's canal, and has an interior diameter of between 100 and 200 μm, and a length of between 1 and 3 mm.
Claim 12
Dependent Claim
27 words
The microfistula, tube as claimed in claim 10 wherein the microfistula tube has an interior diameter of approximately 150 μm and a length of approximately 2 mm.
Claim 13
Dependent Claim
47 words
The microfistula tube as claimed in claim 1 wherein the microfistula tube is adapted to form a passage from the anterior chamber to the anterior subconjunctival space and has an interior diameter of between 100 and 400 μm and a length of between 2 and 6 mm.
Claim 14
Dependent Claim
22 words
The microfistula tube as claimed in claim 12 wherein the microfistula tube has an interior diameter of between 250 and 350 μm.
Claim 15
Dependent Claim
27 words
The microfistula tube as claimed in claim 12 wherein the microfistula tube has an interior diameter of approximately 300 μm and a length of approximately 3 mm.
Claim 16
Dependent Claim
45 words
The microfistula tube as claimed in claim 1 wherein the microfistula tube is adapted to form a passage from the anterior chamber to the episcleral vein, with an inner diameter of between 100 and 300 μm and a length of between 7 and 14 mm.
Claim 17
Dependent Claim
27 words
The microfistula tube as claimed in claim 15 wherein the microfistula tube has an inner diameter of approximately 150 μm and a length of approximately 10 mm.
Claim 18
Dependent Claim
50 words
The microfistula tube as claimed in claim 1 wherein the microfistula tube is adapted to form a passage from the vitreal cavity to the subarachnoid space of the optic nerve, and has an inner diameter of between 100 and 300 μm and a length of between 3 and 12 mm.
Claim 19
Dependent Claim
27 words
The microfistula tube as claimed in claim 17 wherein the microfistula tube has an inner diameter of approximately 150 μm. and a length of approximately 6 mm.
Claim 20
Dependent Claim
84 words
A microfistula tube implantation system comprising: the microfistula tube as claimed in claim 1 ; and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube.
Claim 21
Dependent Claim
22 words
The microfistula tube implantation system as claimed in claim 19 , wherein said microfistula tube is adapted to receive said innermost rod.
Claim 22
Dependent Claim
18 words
The microfistula tube implantation system as claimed in claim 19 wherein the outer tube is a hypodermic-type tube.
Claim 23
Dependent Claim
16 words
The microfistula tube implantation system as claimed in claim 19 wherein the inner tube is blunt-ended.
Claim 24
Dependent Claim
17 words
The microfistula tube implantation system as claimed in claim 19 wherein the innermost rod is of tungsten.
Claim 25
Dependent Claim
23 words
The microfistula tube implantation system as claimed in claim 19 wherein the surgical instrument is adapted to be attached to an ultramicrosurgical system.
Claim 26
Dependent Claim
22 words
The microfistula tube implantation system as claimed in claim 19 wherein the surgical instrument is adapted to be manipulated by electric motors.
Claim 27
Dependent Claim
76 words
A method for the implantation of a microfistula tube comprising: introducing into the vicinity of a desired implantation location the implantation system as claimed in claim 19 with said microfistula tube mounted on the innermost rod, pushing the microfistula tube out of the outer tube and into a desired location by means of the inner tube, the rod moving in unison with the inner tube and the microfistula tube, withdrawing the surgical instrument from the body.
Claim 28
Dependent Claim
22 words
The method as claimed in claim 26 wherein the rod is withdrawn from the microfistula tube before the inner tube is withdrawn.
Claim 29
Dependent Claim
32 words
The method as claimed in claim 26 wherein the rod and inner tube are withdrawn into the outer tube before the inner tube, outer tube and rod are withdrawn from the body.
Claim 30
Dependent Claim
15 words
The method as claimed in claim 26 wherein the desired location is the anterior chamber.
Claim 31
Dependent Claim
125 words
A microfistula tube implantation system comprising: the microfistula tube as claimed in claim 1 ; and a surgical instrument including an outer tube for cutting and penetrating body tissue, and an inner rod, wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube, said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site.
Claim 32
Dependent Claim
64 words
A method for the implantation of a microfistula tube comprising: forming a passage with a outer tube of the implantation system as claimed in claim 30 with said microfistula tube in said outer tube forward of said inner rod, advancing said microfistula tube to said implantation site with said inner rod, withdrawing said outer tube, withdrawing said inner rod, and withdrawing the surgical instrument.
Claim 33
Dependent Claim
30 words
The method as claimed in claim 31 including withdrawing the outer tube partially, then withdrawing said inner rod partially, followed by withdrawing said inner rod and outer tube in unison.
Claim 34
Dependent Claim
28 words
The method as claimed in claim 32 wherein said partial withdrawal of the outer tube continues until said forward of said outer tube is in the anterior chamber.
Claim 35
Dependent Claim
23 words
The method as claimed in claim 31 including rotating said outer tube while forming said passage to aid said cutting of said tissue.
Claim 36
Dependent Claim
106 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said soluble tube is made of gelatin or collagen wherein said microfistula tube has a rearward end having thicker walls to provide improved area and strength to allow the microfistula tube to be pushed into place by pressing against the rearward end of the microfistula tube.
Claim 37
Dependent Claim
106 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said soluble tube is made of gelatin or collagen wherein said microfistula tube has a rearward end having thicker walls to provide improved area and strength to allow the microfistula tube to be pushed into place by pressing against the rearward end of the microfistula tube.
Claim 38
Dependent Claim
18 words
The microfistula tube as claimed in claim 35 wherein the biological cells are endothelial or trabecular meshwork cells.
Claim 39
Dependent Claim
23 words
The microfistula tube as claimed in claim 35 wherein the microfistula tube is sufficiently rigid to allow ready insertion into a living body.
Claim 40
Dependent Claim
111 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and said soluble tube is provided with one or more generally rearwardly projecting barbs or a generally rearwardly projecting skirt.
Claim 41
Dependent Claim
111 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and said soluble tube is provided with one or more generally rearwardly projecting barbs or a generally rearwardly projecting skirt.
Claim 42
Dependent Claim
20 words
The microfistula tube as claimed in claim 38 wherein the biological cells coat the inner surface of the drainage canal.
Claim 43
Dependent Claim
18 words
The microfistula tube as claimed in claim 38 wherein the microfistula tube is made of a mouldable material.
Claim 44
Dependent Claim
18 words
The microfistula tube as claimed in claim 38 wherein the biological cells are endothelial or trabecular meshwork cells.
Claim 45
Dependent Claim
18 words
The microfistula tube as claimed in claim 38 wherein the soluble tube is made of gelatin or collagen.
Claim 46
Dependent Claim
23 words
The microfistula tube as claimed in claim 38 wherein the microfistula tube is sufficiently rigid to allow ready insertion into a living body.
Claim 47
Dependent Claim
29 words
The microfistula tube as claimed in claim 38 wherein the circumferential outer surface of the microfistula tube tapers towards its forward end to facilitate its insertion into body tissues.
Claim 48
Dependent Claim
26 words
The microfistula tube as claimed in claim 38 wherein said one or more barbs or said skirt is near the forward end of said microfistula tube.
Claim 49
Dependent Claim
45 words
The microfistula tube as claimed in claim 38 wherein said microfistula tube has a rearward end having thicker walls to provide improved area and strength to allow the microfistula tube to be pushed into place by pressing against the rearward end of the microfistula tube.
Claim 50
Dependent Claim
34 words
The microfistula tube as claimed in claim 38 wherein the microfistula tube has a rearward end having an increased outer perimeter size to prevent the microfistula tube from advancing beyond the point of implantation.
Claim 51
Dependent Claim
45 words
The microfistula tube as claimed in claim 38 wherein the microfistula tube is adapted to form a passage from the anterior chamber to Schlemm's canal, and has an interior diameter of between 100 and 200 μm, and a length of between 1 and 3 mm.
Claim 52
Dependent Claim
27 words
The microfistula tube as claimed in claim 48 wherein the microfistula tube has an interior diameter of approximately 150 μm and a length of approximately 2 mm.
Claim 53
Dependent Claim
47 words
The microfistula tube as claimed in claim 38 wherein the microfistula tube is adapted to form a passage from the anterior chamber to the anterior subconjunctival space and has an interior diameter of between 100 and 400 μm and a length of between 2 and 6 mm.
Claim 54
Dependent Claim
22 words
The microfistula tube as claimed in claim 50 wherein the microfistula tube has an interior diameter of between 250 and 350 μm.
Claim 55
Dependent Claim
27 words
The microfistula tube as claimed in claim 50 wherein the microfistula tube has an interior diameter of approximately 300 μm and a length of approximately 3 mm.
Claim 56
Dependent Claim
45 words
The microfistula tube as claimed in claim 38 wherein the microfistula tube is adapted to form a passage from the anterior chamber to the episcleral vein, with an inner diameter of between 100 and 300 μm and a length of between 7 and 14 mm.
Claim 57
Dependent Claim
27 words
The microfistula tube as claimed in claim 53 wherein the microfistula tube has an inner diameter of approximately 150 μm and a length of approximately 10 mm.
Claim 58
Dependent Claim
49 words
The microfistula tube as claimed in claim 38 wherein the microfistula tube is adapted to form a passage from the vitreal cavity to the subarachnoid space of the optic nerve, and has an inner diameter of between 100 and 300 μand a length of between 3 and 12 mm.
Claim 59
Dependent Claim
27 words
The microfistula tube as claimed in claim 55 wherein the microfistula tube has an inner diameter of approximately 150 μm and a length of approximately 6 mm.
Claim 60
Dependent Claim
141 words
A microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube, and said outer tube is a hypodermic-type tube.
Claim 61
Dependent Claim
141 words
A microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube, and said outer tube is a hypodermic-type tube.
Claim 62
Dependent Claim
22 words
The microfistula tube implantation system as claimed in claim 57 , wherein said microfistula tube is adapted to receive said innermost rod.
Claim 63
Dependent Claim
16 words
The microfistula tube implantation system as claimed in claim 57 wherein the inner tube is blunt-ended.
Claim 64
Dependent Claim
17 words
The microfistula tube implantation system as claimed in claim 57 wherein the innermost rod is of tungsten.
Claim 65
Dependent Claim
23 words
The microfistula tube implantation system as claimed in claim 57 wherein the surgical instrument is adapted to be attached to an ultramicrosurgical system.
Claim 66
Dependent Claim
22 words
The microfistula tube implantation system as claimed in claim 57 wherein the surgical instrument is adapted to be manipulated by electric motors.
Claim 67
Dependent Claim
244 words
A microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and wherein said microfistula tube has a rearward end having thicker walls to provide improved area and strength to allow the microfistula tube to be pushed into place by pressing against the rearward end of the microfistula tube, a surgical instrument including an outer tube for cutting and penetrating body tissue, and an inner rod, wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube, said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site.
Claim 68
Dependent Claim
244 words
A microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and wherein said microfistula tube has a rearward end having thicker walls to provide improved area and strength to allow the microfistula tube to be pushed into place by pressing against the rearward end of the microfistula tube, a surgical instrument including an outer tube for cutting and penetrating body tissue, and an inner rod, wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube, said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site.
Claim 69
Independent Claim
220 words
A method for the implantation of a microfistula tube comprising: 1) introducing into the vicinity of a desired implantation location a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for penetrating body tissue, and inner tube, and an innermost rod, wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube; 2) mounting said microfistula tube on the innermost rod; 3) pushing the microfistula tube out of the outer tube and into a desired location by means of the inner tube, the rod moving in unison with the inner tube and the microfistula tube; and 4) withdrawing the surgical instrument from the body; wherein said rod is withdrawn from the microfistula tube before said inner tube is withdrawn.
Claim 70
Independent Claim
220 words
A method for the implantation of a microfistula tube comprising: 1) introducing into the vicinity of a desired implantation location a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for penetrating body tissue, and inner tube, and an innermost rod, wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube; 2) mounting said microfistula tube on the innermost rod; 3) pushing the microfistula tube out of the outer tube and into a desired location by means of the inner tube, the rod moving in unison with the inner tube and the microfistula tube; and 4) withdrawing the surgical instrument from the body; wherein said rod is withdrawn from the microfistula tube before said inner tube is withdrawn.
Claim 71
Dependent Claim
32 words
The method as claimed in claim 64 wherein the rod and inner tube are withdrawn into the outer tube before the inner tube, outer tube and rod are withdrawn from the body.
Claim 72
Dependent Claim
15 words
The method as claimed in claim 64 wherein the desired location is the anterior chamber.
Claim 73
Independent Claim
213 words
A method for the implantation of a microfistula tube comprising: 1) introducing into the vicinity of a desired implantation location a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube; 2) mounting said microfistula tube on the innermost rod; 3) pushing the microfistula tube out of the outer tube and into a desired location by means of the inner tube, the rod moving in unison with the inner tube and the microfistula tube; and 4) withdrawing the surgical instrument from the body; wherein said desired location is the anterior chamber.
Claim 74
Independent Claim
213 words
A method for the implantation of a microfistula tube comprising: 1) introducing into the vicinity of a desired implantation location a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube; 2) mounting said microfistula tube on the innermost rod; 3) pushing the microfistula tube out of the outer tube and into a desired location by means of the inner tube, the rod moving in unison with the inner tube and the microfistula tube; and 4) withdrawing the surgical instrument from the body; wherein said desired location is the anterior chamber.
Claim 75
Dependent Claim
32 words
The method as claimed in claim 67 wherein the rod and inner tube are withdrawn into the outer tube before the inner tube, outer tube and rod are withdrawn from the body.
Claim 76
Independent Claim
250 words
A method for the implantation of a microfistula tube comprising: 1) forming passage with an outer tube of a implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including said outer tube for penetrating body tissue, an inner tube, and an innermost rod; wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube, and wherein the surgical instrument is adapted to be manipulated by electric motors; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) advancing said microfistula tube to said implantation site with said inner rod; 4) withdrawing said outer tube partially, then withdrawing said inner rod partially, followed by withdrawing said inner rod and outer tube in unison, wherein said partial withdrawal of the outer tine continues until a forward end of said outer tube is in the anterior chamber of the eye—has been added; 5) withdrawing said innermost rod; and 6) withdrawing the surgical instrument.
Claim 77
Independent Claim
250 words
A method for the implantation of a microfistula tube comprising: 1) forming passage with an outer tube of a implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including said outer tube for penetrating body tissue, an inner tube, and an innermost rod; wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube, and wherein the surgical instrument is adapted to be manipulated by electric motors; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) advancing said microfistula tube to said implantation site with said inner rod; 4) withdrawing said outer tube partially, then withdrawing said inner rod partially, followed by withdrawing said inner rod and outer tube in unison, wherein said partial withdrawal of the outer tine continues until a forward end of said outer tube is in the anterior chamber of the eye—has been added; 5) withdrawing said innermost rod; and 6) withdrawing the surgical instrument.
Claim 78
Independent Claim
281 words
A method for the implantation of a microfistula tube comprising: 1) forming a passage with an outer tube of a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for cutting and penetrating body tissue, and an inner rod; wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube, said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) advancing said microfistula tube to said implantation site with said inner rod; 4) withdrawing said outer tube partially, then withdrawing said inner rod partially, followed by withdrawing said inner rod and outer tube in unison, wherein said partial withdrawal of the outer tine continues until a forward end of said outer tube is in the anterior chamber of the eye—has been added; 5) withdrawing said inner rod; and 6) withdrawing the surgical instrument.
Claim 79
Independent Claim
281 words
A method for the implantation of a microfistula tube comprising: 1) forming a passage with an outer tube of a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including an outer tube for cutting and penetrating body tissue, and an inner rod; wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube, said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) advancing said microfistula tube to said implantation site with said inner rod; 4) withdrawing said outer tube partially, then withdrawing said inner rod partially, followed by withdrawing said inner rod and outer tube in unison, wherein said partial withdrawal of the outer tine continues until a forward end of said outer tube is in the anterior chamber of the eye—has been added; 5) withdrawing said inner rod; and 6) withdrawing the surgical instrument.
Claim 80
Dependent Claim
127 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body; biological cells for forming a basement membrane of for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said microfistula tube is made of absorbable material; and wherein the microfistula tube has a rearward end having an increased outer perimeter size to prevent the microfistula tube from advancing beyond the point of implantation.
Claim 81
Dependent Claim
127 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body; biological cells for forming a basement membrane of for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said microfistula tube is made of absorbable material; and wherein the microfistula tube has a rearward end having an increased outer perimeter size to prevent the microfistula tube from advancing beyond the point of implantation.
Claim 82
Dependent Claim
96 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said soluble tube is made of gelatin or collagen; and wherein the microfistula tube has a rearward end having an increased outer perimeter size to prevent the microfistula tube from advancing beyond the point of implantation.
Claim 83
Dependent Claim
96 words
A microfistula tube comprising: a biocompatible, soluble tube defining a drainage canal having an inner surface; and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane; wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, and wherein said soluble tube is made of gelatin or collagen; and wherein the microfistula tube has a rearward end having an increased outer perimeter size to prevent the microfistula tube from advancing beyond the point of implantation.
Claim 84
Dependent Claim
237 words
A microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, wherein the microfistula tube has a rearward end having an increased outer perimeter size to prevent the microfistula tube from advancing beyond the point of implantation; and a surgical instrument including an outer tube for cutting and penetrating body tissue, and an inner rod, wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube at said site, and said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site.
Claim 85
Dependent Claim
237 words
A microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface and, when said soluble tube is disposed in the body of a patient, said soluble tube is functional as a drainage tube and will eventually fully dissolve and be absorbed by the body, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells, wherein the microfistula tube has a rearward end having an increased outer perimeter size to prevent the microfistula tube from advancing beyond the point of implantation; and a surgical instrument including an outer tube for cutting and penetrating body tissue, and an inner rod, wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube at said site, and said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site.
Claim 86
Independent Claim
226 words
A method for the implantation of a microfistula tube comprising: 1) forming a passage with an outer tube of an implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including said outer tube for cutting and penetrating body tissue, and an inner tube, and an innermost rod; wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube, and wherein the surgical instrument is adapted to be manipulated by electric motors; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) rotating said outer tube while forming said passage to aid in the cutting of the tissue; 4) advancing said microfistula tube to said implantation site with said inner rod; 5) withdrawing said outer tube; 6) withdrawing said innermost rod; and 7) withdrawing the surgical instrument.
Claim 87
Independent Claim
226 words
A method for the implantation of a microfistula tube comprising: 1) forming a passage with an outer tube of an implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including said outer tube for cutting and penetrating body tissue, and an inner tube, and an innermost rod; wherein said outer tube, said inner tube and said innermost rod are coaxial, said outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube, and wherein the surgical instrument is adapted to be manipulated by electric motors; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) rotating said outer tube while forming said passage to aid in the cutting of the tissue; 4) advancing said microfistula tube to said implantation site with said inner rod; 5) withdrawing said outer tube; 6) withdrawing said innermost rod; and 7) withdrawing the surgical instrument.
Claim 88
Independent Claim
253 words
A method for the implantation of a microfistula tube comprising: 1) forming a passage with an outer tube of a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including said outer tube for cutting and penetrating body tissue, and an inner rod; wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube, said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) rotating said outer tube while forming said passage to aid in the cutting of the tissue; 4) advancing said microfistula tube to said implantation site with said inner rod; 5) withdrawing said outer tube; 6) withdrawing said inner rod; and 7) withdrawing the surgical instrument.
Claim 89
Independent Claim
253 words
A method for the implantation of a microfistula tube comprising: 1) forming a passage with an outer tube of a microfistula tube implantation system comprising: a microfistula tube comprising a biocompatible, soluble tube defining a drainage canal having an inner surface, and biological cells for forming a basement membrane or for forming an intracellular matrix and a basement membrane, wherein said soluble tube is coated with said biological cells, incorporates said biological cells or both incorporates and is coated with said biological cells; and a surgical instrument including said outer tube for cutting and penetrating body tissue, and an inner rod; wherein said outer tube and said inner rod are coaxial, said outer tube is adapted to receive said microfistula tube and said inner rod, and said outer tube has a sharp forward end for cutting body tissue, whereby the outer tube may be used to create a passage to an implantation site for said microfistula tube, said inner rod may be used to position a microfistula tube at said site, and said inner rod and outer tube may be withdrawn from said site leaving said microfistula tube in position at said site; 2) locating said microfistula tube in said outer tube forward of said inner rod; 3) rotating said outer tube while forming said passage to aid in the cutting of the tissue; 4) advancing said microfistula tube to said implantation site with said inner rod; 5) withdrawing said outer tube; 6) withdrawing said inner rod; and 7) withdrawing the surgical instrument.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-04-07 | 2006-10-07 | 2007-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-04-07 | 2010-10-07 | 2011-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-04-07 | 2014-10-07 | 2015-04-08 | $7700.00 | Window Closed / Lapsed |