Patent US6508802B1 successfully refreshed from Google Patents.
US6508802B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Remote sensing gene therapy delivery device and method of administering a therapeutic solution to a heart
Assignee: Cornell Research Foundation Inc
•
Filing: 2000-05-23
•
Granted: 2003-01-21
•
Expires: 2020-05-23
Abstract
Abstract The invention provides a steerable device for the delivery of a therapeutic solution, in particular, an angiogenesis-promoting substance into a heart, and a method of delivering such a substance into the heart. The device includes an elongated needle which the physician may steer by asserting a tensioning force on a steering cable coupled to the needle toward its distal end. A axially-slidable steering sleeve is disposed about the needle and the steering cable, and the position of the steering sleeve may be adjusted to control the radius of flexure of the needle. The needle body is flexible enough to maneuver around thoracic and cardiac geometry, yet sufficiently rigid to facilitate such maneuvering. The needle may also have a stop, or platform, spaced from the distal needle tip to stabilize the needle in the cardiac tissue. According to a method of the invention, the needle may be inserted into the heart tissue through lung tissue adhering to the heart, as is common in re-operative patients. The platform may either transit the needle as the platform contacts the lung or heart tissue, or the platform may move forward to contact tissue as needle contact with heart tissue is confirmed.
Inventors
- 👤 Todd K. Rosengart
- 👤 Ronald G. Crystal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 21:44
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/01; A61M25/0105; A61M25/0133; A61M25/0147; A61M25/0067; A61M25/0082; A61M25/0084; A61B; A61B17/00; A61B17/00234; A61B2017/00238; A61B2017/00243; A61B2017/00247; A61B2017/00292; A61B2017/003; A61B17/34; A61B2017/348; A61B2017/3482; A61B2017/3484; A61B2017/3488; A61B18/00; A61B2018/00315; A61B2018/00345; A61B2018/00351; A61B2018/00392; A61B90/00; A61B90/03; A61B2090/033; A61M2025/0089
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
188 words
A device for delivering a therapeutic solution from a solution supply into cardiac tissue, the device comprising: a hollow needle having a needle proximal end and a needle distal end, said needle proximal end being adapted for fluid attachment to said solution supply, said needle comprising an elongated flexible body, and a sharpened tip disposed at said needle distal end for penetration of cardiac tissue, a steering cable having a cable distal end secured to the hollow needle at a coupling, said coupling being spaced from the distal end of the hollow needle, said steering cable extending toward the proximal end of the hollow needle and having a cable proximal end, said steering cable being manipulable to flex the needle distal end relative to the needle proximal end along a flexion radius when a tensioning force is applied to the cable proximal end, and a steering sleeve movable disposed about the elongated flexible body and said steering cable such that a distance between the steering sleeve and said coupling determines the flexion radius and whereby movement of the steering sleeve along the hollow needle adjust the flexion radius.
Claim 2
Independent Claim
188 words
A device for delivering a therapeutic solution from a solution supply into cardiac tissue, the device comprising: a hollow needle having a needle proximal end and a needle distal end, said needle proximal end being adapted for fluid attachment to said solution supply, said needle comprising an elongated flexible body, and a sharpened tip disposed at said needle distal end for penetration of cardiac tissue, a steering cable having a cable distal end secured to the hollow needle at a coupling, said coupling being spaced from the distal end of the hollow needle, said steering cable extending toward the proximal end of the hollow needle and having a cable proximal end, said steering cable being manipulable to flex the needle distal end relative to the needle proximal end along a flexion radius when a tensioning force is applied to the cable proximal end, and a steering sleeve movable disposed about the elongated flexible body and said steering cable such that a distance between the steering sleeve and said coupling determines the flexion radius and whereby movement of the steering sleeve along the hollow needle adjust the flexion radius.
Claim 3
Dependent Claim
38 words
The device as claimed in claim 1 wherein the hollow needle further comprises a platform spaced from the distal end, said platform acting to stabilize the needle relative to the cardiac tissue during delivery of the therapeutic solution.
Claim 4
Dependent Claim
17 words
The device as claimed in claim 2 wherein the platform is movable relative to the hollow needle.
Claim 5
Dependent Claim
15 words
The device as claimed in claim 3 wherein the platform may slide along the needle.
Claim 6
Dependent Claim
12 words
The device as claimed in claim 3 wherein the platform is inflatable.
Claim 7
Dependent Claim
37 words
The device as claimed in claim 1 further comprising an electrode coupled to the needle and adapted for connection to an ECG to provide an electrical indication of when said sharpened tip has penetrated said cardiac tissue.
Claim 8
Dependent Claim
16 words
The device as claimed in claim 6 wherein the electrode is coupled to the sharpened tip.
Claim 9
Dependent Claim
38 words
The device as claimed in claim 3 further comprising an electrode coupled to the needle tip and adapted for connection to an ECG to provide an electrical indication of when said sharpened tip has penetrated said cardiac tissue.
Claim 10
Dependent Claim
25 words
The device as claimed in claim 1 further comprising a steering sleeve adjustment cable for adjusting the distance between the steering sleeve and the coupling.
Claim 11
Dependent Claim
16 words
The device as claimed in claim 9 wherein the steering sleeve adjustment cable is stainless steel.
Claim 12
Dependent Claim
37 words
The device as claimed in claim 9 wherein the steering sleeve adjustment cable is sufficiently resistant to bending that the steering sleeve adjustment cable may be used to push the steering sleeve toward the needle distal end.
Claim 13
Independent Claim
98 words
A device for delivering a therapeutic solution from a solution supply into target tissue, the device comprising: a hollow needle having a needle proximal end and a needle distal end, said needle proximal end being adapted for fluid attachment to said solution supply, said needle comprising an elongated flexible body, a sharpened tip disposed at said needle distal end for penetration of target tissue, and a platform moveably disposed along the needle body and spaced from the needle distal end, said platform acting to stabilize the needle relative to the target tissue during delivery of the therapeutic solution.
Claim 14
Independent Claim
98 words
A device for delivering a therapeutic solution from a solution supply into target tissue, the device comprising: a hollow needle having a needle proximal end and a needle distal end, said needle proximal end being adapted for fluid attachment to said solution supply, said needle comprising an elongated flexible body, a sharpened tip disposed at said needle distal end for penetration of target tissue, and a platform moveably disposed along the needle body and spaced from the needle distal end, said platform acting to stabilize the needle relative to the target tissue during delivery of the therapeutic solution.
Claim 15
Dependent Claim
15 words
The device as claimed in claim 12 wherein the platform may slide along the needle.
Claim 16
Dependent Claim
34 words
The device as claimed in claim 13 further comprising a platform adjustment structure extending adjacent the needle body, said platform adjustment structure being disposed to contact the platform and adjustable to move the platform.
Claim 17
Dependent Claim
22 words
The device as claimed in claim 14 wherein the platform adjustment structure is a platform adjustment sleeve disposed about the needle body.
Claim 18
Dependent Claim
35 words
The device as claimed in claim 15 wherein the platform adjustment sleeve comprises a slot for receiving the distal end of the steering cable, and the steering sleeve is disposed about the platform adjustment sleeve.
Claim 19
Dependent Claim
12 words
The device as claimed in claim 12 wherein the platform is inflatable.
Claim 20
Dependent Claim
26 words
The device as claimed in claim 17 further comprising a gas conduit fluidly coupled to the platform and adapted for connection to a source of gas.
Claim 21
Dependent Claim
37 words
The device as claimed in claim 12 further comprising an electrode coupled to the needle and adapted for connection to an ECG to provide an electrical indication of when said sharpened tip has penetrated said target tissue.
Claim 22
Dependent Claim
16 words
The device as claimed in claim 19 wherein the electrode is coupled to the sharpened tip.
Claim 23
Dependent Claim
147 words
The device as claimed in claim 12 further comprising a steering cable having a cable distal end secured to the hollow needle at a coupling, said coupling being spaced from the distal end of the hollow needle, said steering cable extending toward the proximal end of the hollow needle and having a cable proximal end, said steering cable being manipulable to flex the needle distal end relative to the needle proximal end along a flexion radius when a tensioning force is applied to the cable proximal end, a steering sleeve movably disposed about the elongated flexible body and said steering cable such that a distance between the steering sleeve and coupling determines the flexion radius and whereby movement of the steering sleeve along the hollow needle adjusts the flexion radius, and a steering sleeve adjustment cable for adjusting the distance between the steering sleeve and the coupling.
Claim 24
Dependent Claim
37 words
The device as claimed in claim 21 wherein the steering sleeve adjustment cable is sufficiently resistant to bending that the steering sleeve adjustment cable may be used to push the steering sleeve toward the needle distal end.
Claim 25
Independent Claim
70 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's thoracic cavity through an opening in the patient's chest wall, said delivery device having a needle for injecting the therapeutic substance into the heart tissue, passing the needle through the patient's lung tissue and into the heart tissue, and delivering the therapeutic substance to the patient's heart.
Claim 26
Independent Claim
70 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's thoracic cavity through an opening in the patient's chest wall, said delivery device having a needle for injecting the therapeutic substance into the heart tissue, passing the needle through the patient's lung tissue and into the heart tissue, and delivering the therapeutic substance to the patient's heart.
Claim 27
Dependent Claim
19 words
The method of claim 23 further comprising the step of at least partially collapsing one of the patient's lungs.
Claim 28
Dependent Claim
24 words
The method of claim 23 further comprising the step of providing an indication of when the needle penetrates the heart tissue of the patient.
Claim 29
Dependent Claim
40 words
The method of claim 25 wherein the step of providing an indication comprises the step of providing an electrode along the needle, said electrode being electrically connected with a device for indicating when the patient's heart tissue has been penetrated.
Claim 30
Dependent Claim
44 words
The method of claim 23 further comprising the steps stabilizing the needle during the delivering step by contacting the lung tissue with a platform disposed about the needle and moving the platform axially relative to the needle as the platform contacts the lung tissue.
Claim 31
Dependent Claim
28 words
The method of claim 23 further comprising the steps stabilizing the needle during the delivering step by contacting the cardiac tissue with a platform disposed about the needle.
Claim 32
Dependent Claim
16 words
The method of claim 28 wherein the stabilizing step comprises the step of inflating the platform.
Claim 33
Dependent Claim
18 words
The method of claim 29 further comprising the step of passing the uninflated platform through the lung tissue.
Claim 34
Dependent Claim
42 words
The method of claim 23 further comprising the step of steering the distal end of the needle along a flexion radius using a steering cable coupled to the needle toward the distal end of the needle and extending substantially along the needle.
Claim 35
Dependent Claim
27 words
The method of claim 31 further comprising the step of adjusting the flexion radius by moving a steering sleeve disposed about the needle and the steering cable.
Claim 36
Dependent Claim
24 words
The method of claim 32 further comprising the step of moving the steering sleeve axially along the needle using a steering sleeve adjustment cable.
Claim 37
Independent Claim
145 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's thoracic cavity through an opening in the patient's chest wall, said delivery device having a needle for injecting the therapeutic substance into the heart tissue, exerting a force on the proximal end of a steering cable, the distal end of the steering cable being coupled to the needle toward the needle distal end to steer the needle distal end along a flexion radius, adjusting the flexion radius by moving a steering sleeve disposed about the needle and the steering cable axially along the needle, the steering cable extending through the steering sleeve such that the proximal end of the steering sleeve is accessible to the user, passing the needle into the heart tissue, and delivering the therapeutic substance to the patient's heart.
Claim 38
Independent Claim
145 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's thoracic cavity through an opening in the patient's chest wall, said delivery device having a needle for injecting the therapeutic substance into the heart tissue, exerting a force on the proximal end of a steering cable, the distal end of the steering cable being coupled to the needle toward the needle distal end to steer the needle distal end along a flexion radius, adjusting the flexion radius by moving a steering sleeve disposed about the needle and the steering cable axially along the needle, the steering cable extending through the steering sleeve such that the proximal end of the steering sleeve is accessible to the user, passing the needle into the heart tissue, and delivering the therapeutic substance to the patient's heart.
Claim 39
Dependent Claim
40 words
The method of claim 34 wherein the step of adjusting the flexion radius comprises the step of applying a force to a steering sleeve adjustment cable coupled to the steering sleeve to move the steering sleeve axially along the needle.
Claim 40
Independent Claim
87 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's body cavity through an opening, said delivery device having a needle for injecting the therapeutic substance into the tissue, contacting a sharpened tip of the needle with the heart tissue, penetrating the heart tissue with the sharpened tip, contacting a platform disposed about the needle with body tissue, moving the platform axially relative to the needle, delivering the therapeutic substance to the patient's heart.
Claim 41
Independent Claim
87 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's body cavity through an opening, said delivery device having a needle for injecting the therapeutic substance into the tissue, contacting a sharpened tip of the needle with the heart tissue, penetrating the heart tissue with the sharpened tip, contacting a platform disposed about the needle with body tissue, moving the platform axially relative to the needle, delivering the therapeutic substance to the patient's heart.
Claim 42
Dependent Claim
24 words
The method of claim 36 further comprising the step of providing an indication of when the needle penetrates the heart tissue of the patient.
Claim 43
Dependent Claim
40 words
The method of claim 37 wherein the step of providing an indication comprises the step of providing an electrode along the needle, said electrode being electrically connected with a device for indicating when the patient's heart tissue has been penetrated.
Claim 44
Independent Claim
77 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's body cavity through an opening, said delivery device having a needle for injecting the therapeutic substance into the tissue, contacting a sharpened tip of the needle with the heart tissue, penetrating the heart tissue with the sharpened tip, inflating a platform disposed adjacent the heart tissue, delivering the therapeutic substance to the patient's heart.
Claim 45
Independent Claim
77 words
A method of delivering a therapeutic substance to heart tissue of a patient, the method comprising: inserting a delivery device into the patient's body cavity through an opening, said delivery device having a needle for injecting the therapeutic substance into the tissue, contacting a sharpened tip of the needle with the heart tissue, penetrating the heart tissue with the sharpened tip, inflating a platform disposed adjacent the heart tissue, delivering the therapeutic substance to the patient's heart.
Claim 46
Dependent Claim
16 words
The method of claim 39 further comprising the step of passing the needle through lung tissue.
References Cited (Backward Citations)
US510413A
Cited
US2402306A
Cited
US2512568A
Cited
US2551902A
Cited
US2498692A
Cited
US2670673A
Cited
US2700385A
Cited
US2688329A
Cited
US2952256A
Cited
US3467096A
Cited
US3435824A
Cited
US3487837A
Cited
US3530492A
Cited
US3595231A
Cited
US3572336A
Cited
US3920001A
Cited
US3797491A
Cited
US3831584A
Cited
US3765420A
Cited
US3783876A
Cited
US3826241A
Cited
US3951132A
Cited
US3991767A
Cited
US4245624A
Cited
US4150669A
Cited
US4168708A
Cited
US4167179A
Cited
US4222380A
Cited
US4230119A
Cited
US4299230A
Cited
US4356826A
Cited
US4243035A
Cited
US4280508A
Cited
US4578061A
Cited
US4419094A
Cited
US4674506A
Cited
US4645495A
Cited
US4946442A
Cited
US4877037A
Cited
US4753236A
Cited
US4721109A
Cited
US5335670A
Cited
US5080104A
Cited
US4760847A
Cited
US4838851A
Cited
US5323789A
Cited
US4861336A
Cited
US4798193A
Cited
US4787891A
Cited
US4919653A
Cited
US5195526A
Cited
US4966589A
Cited
US4994041A
Cited
US4932421A
Cited
US4940458A
Cited
US4976688A
Cited
US5425739A
Cited
US5192289A
Cited
US4946463A
Cited
DE3920707A1
Cited
US5098412A
Cited
US5322510A
Cited
US5036868A
Cited
US5820591A
Cited
US5254088A
Cited
US5395327A
Cited
US5531686A
Cited
US5336182A
Cited
US6033378A
Cited
US5121750A
Cited
US5037428A
Cited
US5192270A
Cited
US5146913A
Cited
US5147307A
Cited
US5417662A
Cited
US5376084A
Cited
US5269754A
Cited
US5259377A
Cited
US5364374A
Cited
US5611778A
Cited
US5290258A
Cited
US5273525A
Cited
US5354279A
Cited
US5261889A
Cited
US5478330A
Cited
US5312351A
Cited
US5536251A
Cited
US5522815A
Cited
US5441499A
Cited
US6277107B1
Cited
US5569217A
Cited
US5380292A
Cited
US5673704A
Cited
US5464395A
Cited
US5810757A
Cited
US5674197A
Cited
US5417683A
Cited
US5713890A
Cited
US5478315A
Cited
US5520650A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-01-20 | 2006-07-22 | 2007-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-01-20 | 2010-07-22 | 2011-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-01-20 | 2014-07-22 | 2015-01-21 | $7700.00 | Window Closed / Lapsed |