US5364374A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microneedle for injection of ocular blood vessels
Assignee: State of Oregon
•
Filing: 1993-09-24
•
Granted: 1994-11-15
•
Expires: 2013-09-24
Abstract
Abstract This invention is a device for microvascular injection and a method for treating glaucoma using the device. The device comprises a reservoir attached to a blunted needle connected to a flexible tapered tubing, at the end of which is positioned a microneedle or micropipette for inserting into small blood vessels. The invention also provides a method for treating glaucoma and other diseases wherein microinjection of disease-ameliorating drugs into small blood vessels and their capillary beds would be therapeutically effective.
Inventors
- 👤 John C. Morrison
- 👤 Chester G. Moore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 11:01
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0015; A61F; A61F9/00; A61F9/007; A61F9/00781; A61M5/00; A61M5/178; A61M5/31; A61M5/32; A61M25/00; A61M25/0021; A61M2025/0042; A61M25/0067; A61M25/0082; A61M25/0084; A61M2025/0089; A61M2210/00; A61M2210/06; A61M2210/0612
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
186 words
A device for microvascular injection of a solution into a small blood vessel in vivo, comprising in combination: a) a reservoir comprising a syringe and a hypodermic needle; b) a flexible tubing having a continuously tapered bore and a first end and a second end, the first end of the flexible tubing being operatively linked to the hypodermic needle, wherein the bore of the flexible tubing is at least about 300 microns in inner diameter at the first end and is sufficient to fit over the hypodermic needle; and c) a microneedle having a length of about 1 to about 5 millimeters and an outer diameter of about 20 microns to about 100 microns, and a first end and a second end, the first end of the microneedle being operatively linked to the second end of the flexible tubing, wherein the bore of the flexible tubing is from about 20 microns to about 100 microns in width at said second end and is sufficient to fit over the first end of the microneedle, wherein the microneedle is further characterized by having sides that are not tapered.
Claim 2
Independent Claim
186 words
A device for microvascular injection of a solution into a small blood vessel in vivo, comprising in combination: a) a reservoir comprising a syringe and a hypodermic needle; b) a flexible tubing having a continuously tapered bore and a first end and a second end, the first end of the flexible tubing being operatively linked to the hypodermic needle, wherein the bore of the flexible tubing is at least about 300 microns in inner diameter at the first end and is sufficient to fit over the hypodermic needle; and c) a microneedle having a length of about 1 to about 5 millimeters and an outer diameter of about 20 microns to about 100 microns, and a first end and a second end, the first end of the microneedle being operatively linked to the second end of the flexible tubing, wherein the bore of the flexible tubing is from about 20 microns to about 100 microns in width at said second end and is sufficient to fit over the first end of the microneedle, wherein the microneedle is further characterized by having sides that are not tapered.
Claim 3
Dependent Claim
15 words
A device according to claim 1 wherein the second end of the microneedle is beveled.
Claim 4
Dependent Claim
12 words
A device according to claim 1 wherein the hypodermic needle is blunted.
Claim 5
Dependent Claim
23 words
A device according to claim 1 having rigid spherical gripping means surrounding the tapered bore of the second end of the flexible tubing.
Claim 6
Dependent Claim
17 words
A device according to claim 4 wherein the rigid spherical gripping means comprises a bead of glue.
Claim 7
Dependent Claim
18 words
A device according to claim 1 wherein the syringe has a volume of 1 to 2 cubic centimeters.
Claim 8
Dependent Claim
15 words
A device according to claim 1 wherein the flexible tubing is constructed of polyethylene plastic.
Claim 9
Dependent Claim
16 words
A device according to claim 1 in which the syringe contains an intraocular pressure lowering agent.
Claim 10
Dependent Claim
14 words
A device according to claim 1 in which the syringe contains an antibacterial agent.
Claim 11
Dependent Claim
14 words
A device according to claim 1 in which the syringe contains an anti-inflammatory agent.
Claim 12
Dependent Claim
14 words
A device according to claim 1 in which the syringe contains an anti-cancer agent.
References Cited (Backward Citations)
US2531667A
Cited
US3986834A
Cited
US4078892A
Cited
US4050316A
Cited
US4191176A
Cited
GB2030865A
Cited
US4349022A
Cited
US4885945A
Cited
US5000732A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-14 | 1998-05-16 | 1998-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-14 | 2002-05-16 | 2002-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-14 | 2006-05-16 | 2006-11-15 | $7700.00 | Window Closed / Lapsed |