Patent US6375634B1 successfully refreshed from Google Patents.
US6375634B1
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US
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Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy
Assignee: CAROLL ROBERT G
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Filing: 1999-04-06
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Granted: 2002-04-23
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Expires: 2019-04-06
Abstract
Abstract Methods for conducting an operation on a living organism are provided, including methods in which a channel is provided around a tissue of the organism, and an encapsulating composition is infused into the channel to encapsulate the tissue in a capsule. The capsule impedes materials encapsulated therein from migrating to other tissues outside the capsule. Also provided are apparatuses for performing methods of the invention. In addition, an improved method of radiation therapy, in which a locally persistent radiation enhancing agent, such as iron dextran or colloidal chromic phosphate P-32, is administered in or near a tissue to be treated, is provided. The methods and apparatuses are especially useful in the treatment and removal of tumors.
Inventors
- 👤 Robert G. Carroll
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 12:57
CPC Classifications
A; A61; A61B; A61B18/00; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6943; A61B17/00; A61B17/00234; A61B17/00491; A61B2017/00831; A61B2017/00867; A61B17/22; A61B2017/22082; A61B17/32; A61B17/320068; A61B2017/320069; A61B2017/32007
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
58 words
A method for conducting an operation on a living organism, said method comprising: providing a channel around a tissue of said organism; infusing into said channel an encapsulating composition to encapsulate said tissue in a capsule; and evacuating said capsule of its contents including said tissue; wherein said capsule impedes materials encapsulated therein for migrating outside said capsule.
Claim 2
Independent Claim
58 words
A method for conducting an operation on a living organism, said method comprising: providing a channel around a tissue of said organism; infusing into said channel an encapsulating composition to encapsulate said tissue in a capsule; and evacuating said capsule of its contents including said tissue; wherein said capsule impedes materials encapsulated therein for migrating outside said capsule.
Claim 3
Dependent Claim
15 words
The method of claim 1 , wherein said encapsulating composition comprises silk-elastin engineered protein polymers.
Claim 4
Dependent Claim
13 words
The method of claim 1 , wherein said encapsulating composition comprises a hyaluronan.
Claim 5
Dependent Claim
12 words
The method of claim 1 , wherein said encapsulating composition comprises histidine.
Claim 6
Dependent Claim
27 words
The method of claim 1 , further comprising dispensing a therapeutic composition into said channel before said encapsulating composition sets within said channel to form said capsule.
Claim 7
Dependent Claim
13 words
The method of claim 5 , wherein said therapeutic composition comprises a hyaluronan.
Claim 8
Dependent Claim
14 words
The method of claim 5 , wherein said therapeutic composition comprises a radiation sensitizer.
Claim 9
Dependent Claim
20 words
The method of claim 7 , wherein said radiation sensitizer is selected from the group consisting of iron and copper.
Claim 10
Dependent Claim
16 words
The method of claim 5 , wherein said therapeutic composition and said encapsulating composition comprise histidine.
Claim 11
Dependent Claim
50 words
The method of claim 5 , wherein said therapeutic composition is a locally persisting formulation comprising at least one member selected from the group consisting of biologically active agonist hormones, biologically active antagonist hormones, proteins, peptides, amine acids, biological response modifiers, gene therapy agents, angiogenesis agents, chemotherapeutics and colloidal radiopharmaceuticals.
Claim 12
Dependent Claim
20 words
The method of claim 5 , wherein said therapeutic composition is a locally persisting formulation comprising colloidal chromic phosphate P-32.
Claim 13
Dependent Claim
35 words
The method of claim 5 , wherein said therapeutic composition and said encapsulating composition comprise a colloidal metal suspension, and said method further comprises heating said therapeutic and encapsulating compositions by applying radiant energy thereto.
Claim 14
Dependent Claim
21 words
The method of claim 5 , wherein said therapeutic composition is dispensed from a hollow blade which also cuts said channel.
Claim 15
Dependent Claim
17 words
The method of claim 1 , further comprising implanting a sustained release composition within said evacuated capsule.
Claim 16
Dependent Claim
16 words
The method of claim 14 , wherein said sustained release composition comprises colloidal chromic phosphate P-32.
Claim 17
Dependent Claim
55 words
The method of claim 1 , further comprising: inserting a radiation wand within the evacuated capsule, said radiation wand having a radiation emitting portion; inflating a balloon within said evacuated capsule to facilitate centering said radiation emitting portion within said evacuated capsule; and emitting radiation from said centered radiation emitting portion of said radiation wand.
Claim 18
Dependent Claim
17 words
The method of claim 16 , wherein said balloon is inflated with a radiation filtering fluid composition.
Claim 19
Dependent Claim
32 words
The method of claim 17 , wherein said radiation filtering fluid composition comprises a colloidal suspension of copper effective to absorb undesirable x-ray energies and re-radiate characteristic copper x-rays in all directions.
Claim 20
Dependent Claim
24 words
The method of claim 1 , further comprising injecting said evacuated capsule with an aesthetic composition to preserve or enhance tissue volume and contour.
Claim 21
Dependent Claim
12 words
The method of claim 19 , wherein said tissue is breast tissue.
Claim 22
Dependent Claim
13 words
The method of claim 1 , wherein said operation is a breast reduction.
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