US5520916A
Expired / Lapsed
US
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Non-woven fabric material comprising hyaluronic acid derivatives
Assignee: Ministry of Education, Universities and Research
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Filing: 1992-12-18
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Granted: 1996-05-28
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Expires: 2012-12-18
Abstract
Abstract Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable nonwoven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
Inventors
- 👤 Franco Dorigatti
- 👤 Lanfranco Callegaro
- 👤 Aurelio Romeo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 01:06
CPC Classifications
D; D04; D04H; D04H1/00; D04H1/70; D04H1/74; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/28; D01; D01D; D01D5/00; D01D5/06; D01F; D01F9/00; D04H1/40; D04H1/42; D04H1/4266; D04H1/4326; D04H1/435; D04H1/4382; D04H1/43835; D04H1/44; D04H1/46; D04H3/00; D04H3/08; D04H3/12; Y; Y10; Y10T; Y10T428/00; Y10T428/24; Y10T428/24058; Y10T428/24124; Y10T442/00; Y10T442/60; Y10T442/682; Y10T442/684; Y10T442/686; Y10T442/69; Y10T442/692
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
28 words
A non-woven fabric material, comprised of fibers of at least one hyaluronic acid ester or at least one hyaluronic acid ester in combination with fibers of another polymer.
Claim 2
Dependent Claim
28 words
A non-woven fabric material, comprised of fibers of at least one hyaluronic acid ester or at least one hyaluronic acid ester in combination with fibers of another polymer.
Claim 3
Dependent Claim
48 words
The non-woven fabric material of claim 1, wherein said polymer is a member selected from the group consisting of collagen, a coprecipitate of collagen and a glycosaminoglycan, cellulose, a polysaccharide in the form of a gel, a semisynthetic derivative of a polymer, a synthetic polymer, and mixtures thereof.
Claim 4
Dependent Claim
20 words
The non-woven fabric material of claim 2, wherein said polysaccharide in the form of a gel is a natural gum.
Claim 5
Dependent Claim
45 words
The non-woven fabric material of claim 2, wherein said polysaccharide in the form of a gel is a member selected from the group consisting of chitin, chitosan, pectin, pectic acid, agar, agarose, xanthan gum, gellan, alginic acid, an alginate, polymannan, a polyglycan, and a starch.
Claim 6
Dependent Claim
94 words
The non-woven fabric material of claim 2, wherein said semisynthetic derivative of a polymer is a member selected from the group consisting of chemically cross-linked collagen, a derivative of cellulose, a derivative of alginic acid, a derivative of a starch, a derivative of chitin, a derivative of chitosan, a derivative of gellan, a derivative of xanthan, a derivative of pectin, a derivative of pectic acid, a derivative of a polyglycan, a derivative of polymannan, a derivative of agar, a derivative of agarose, a derivative of a natural gum, and a derivative of a glycosaminoglycan.
Claim 7
Dependent Claim
57 words
The non-woven fabric material of claim 2, wherein said synthetic polymer is a member selected from the group consisting of polylactic acid, polyglycolic acid, a copolymer of polylactic acid and polyglycolic acid, a copolymer of a derivative of polylactic acid and a derivative of polyglycolic acid, a polydioxane, a polyphosphazene, a polysulfone resin, and a polyurethane resin.
Claim 8
Dependent Claim
23 words
The non-woven fabric material of claim 1, wherein said hyaluronic acid ester is present alone, or in combination with other hyaluronic acid esters.
Claim 9
Dependent Claim
19 words
The non-woven fabric material of claim 1, wherein said hyaluronic acid ester is the ethyl ester of hyaluronic acid.
Claim 10
Dependent Claim
19 words
The non-woven fabric material of claim 1, wherein said hyaluronic acid ester is the benzyl ester of hyaluronic acid.
Claim 11
Dependent Claim
29 words
The non-woven fabric material of claim 1, wherein said non-woven fabric material comprises a mixture of the ethyl ester of hyaluronic acid and the benzyl ester of hyaluronic acid.
Claim 12
Dependent Claim
30 words
The non-woven fabric material of claim 1, wherein said non-woven fabric material comprises a mixture of the benzyl ester of hyaluronic acid and a partial benzyl ester of hyaluronic acid.
Claim 13
Dependent Claim
19 words
The non-woven fabric material of 11, wherein said partial benzyl ester of hyaluronic acid is a 75% benzyl ester.
Claim 14
Dependent Claim
19 words
The non-woven fabric material of 11, wherein said partial benzyl ester of hyaluronic acid is a 75% benzyl ester.
Claim 15
Dependent Claim
19 words
The non-woven fabric material of claim 1, wherein said non-woven fabric material is impregnated with a pharmacologically active substance.
Claim 16
Dependent Claim
15 words
The non-woven fabric material of claim 13, wherein said pharmacologically active substance is an antibiotic.
Claim 17
Dependent Claim
12 words
The non-woven fabric material of claim 14, wherein said antibiotic is vancomycin.
Claim 18
Dependent Claim
54 words
The non-woven fabric material of claim 1, weighing between about 20 gr/mq and about 500 gr/mq, having a thickness between about 0.2 mm and about 5 mm, a diameter of the fibers between about 12 microns and about 60 microns, and a length of the fibers between about 5 mm and about 100 mm.
Claim 19
Dependent Claim
37 words
The non-woven fabric material of claim 1, weighing about 40 gr/mq, having a thickness of about 0.5 mm, a diameter of the fibers of about 20 microns, and a length of the fibers of about 40 mm.
Claim 20
Dependent Claim
37 words
The non-woven fabric material of claim 1, weighing about 200 gr/mq, having a thickness of about 1.5 mm, a diameter of the fibers of about 20 microns, and a length of the fibers of about 3 mm.
Claim 21
Dependent Claim
18 words
The non-woven fabric material of claim 1, wherein the residual humidity is between about 0.01 and about 10%.
Claim 22
Dependent Claim
27 words
The non-woven fabric material of claim 1, wherein said non-woven fabric material is subjected to chemical cohesive treatment, mechanical cohesive treatment, or treatment with a bonding agent.
Claim 23
Dependent Claim
20 words
The non-woven fabric material of claim 20, wherein said chemical cohesive treatment comprises soaking in a solvent, followed by coagulation.
Claim 24
Dependent Claim
16 words
The non-woven fabric material of claim 20, wherein said mechanical cohesive treatment comprises needle punching treatment.
Claim 25
Dependent Claim
30 words
A non-woven fabric material, comprised of fibers of at least one partial hyaluronic acid ester or at least one partial hyaluronic acid ester in combination with fibers of another polymer.
Claim 26
Dependent Claim
30 words
A non-woven fabric material, comprised of fibers of at least one partial hyaluronic acid ester or at least one partial hyaluronic acid ester in combination with fibers of another polymer.
Claim 27
Dependent Claim
21 words
The non-woven fabric material of claim 23, wherein said partial hyaluronic acid ester is a partial benzyl ester of hyaluronic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-05-28 | 1999-11-27 | 2000-05-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-05-28 | 2003-11-27 | 2004-05-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-05-28 | 2007-11-27 | 2008-05-28 | $7700.00 | Window Closed / Lapsed |