Patent US6356784B1 successfully refreshed from Google Patents.
US6356784B1
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Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus
Assignee: Medtronic Inc
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Filing: 1999-04-30
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Granted: 2002-03-12
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Expires: 2019-04-30
Abstract
Abstract The present invention discloses techniques for treating movement disorders by electrical stimulation and/or drug infusion. The present invention utilizes an implantable signal generator and an electrode and/or an implantable pump and catheter. High electrical stimulation pulses and/or drug therapy is provided to the Pedunculopontine Nucleus (PPN). A sensor may be used to detect various symptoms of the movement disorders. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the PPN.
Inventors
- 👤 Andres M. Lozano
- 👤 Mark T. Rise
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 07:24
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/14244; A61M5/14276; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/3605; A61N1/3606; A61N1/36067; A61M5/168; A61M5/172; A61M5/1723; A61N1/02; A61N1/04; A61N1/05; A61N1/0526; A61N1/0529; A61N1/0534; A61N1/372
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
88 words
A method for treating movement disorders by means of an implantable signal generator and a lead having a proximal end coupled to the signal generator and a distal portion having at least one electrode, the method comprising the steps of: (a) implanting at least one electrode so that the stimulation portion lies at least in direct communication with tissue elements of a pedunculopontine nucleus (PPN); (b) coupling the proximal end of the implanted electrode to the signal generator; and (c) operating the signal generator to stimulate the PPN.
Claim 2
Independent Claim
88 words
A method for treating movement disorders by means of an implantable signal generator and a lead having a proximal end coupled to the signal generator and a distal portion having at least one electrode, the method comprising the steps of: (a) implanting at least one electrode so that the stimulation portion lies at least in direct communication with tissue elements of a pedunculopontine nucleus (PPN); (b) coupling the proximal end of the implanted electrode to the signal generator; and (c) operating the signal generator to stimulate the PPN.
Claim 3
Dependent Claim
40 words
A method, as claimed in claim 1 , further comprising the steps of: (d) sensing the extent of the movement disorder and generating a sensor signal; and (e) regulating the operation of the electrode in response to the sensor signal.
Claim 4
Dependent Claim
21 words
A method, as claimed in claim 2 , wherein said step of regulating comprises the step of executing a control algorithm.
Claim 5
Dependent Claim
35 words
A method, as claimed in claim 3 , wherein said step of generating a sensor signal includes the steps of detecting a symptom of the movement disorder and communicating with the control algorithm by telemetry.
Claim 6
Dependent Claim
25 words
A method, as claimed in claim 2 , wherein the step of sensing includes the step of sensing a physiological symptom of the movement disorder.
Claim 7
Dependent Claim
25 words
A method, as claimed in claim 2 , wherein the step of sensing includes the step of sensing a chemical symptom of the movement disorder.
Claim 8
Dependent Claim
39 words
A method, as claimed in claim 2 , wherein the step of regulating includes the step of adjusting at least one parameter of the stimulation, the parameter being selected from the group consisting of amplitude, pulse width and frequency.
Claim 9
Dependent Claim
30 words
A method, as claimed in claim 7 , further comprising the step of: (f) adjusting at least one parameter of the stimulation downward to decrease the effects of the stimulation.
Claim 10
Dependent Claim
27 words
A method, as claimed in claim 1 , wherein the step of operating includes the step of selecting amplitude, width and frequency of stimulation by the electrode.
Claim 11
Dependent Claim
31 words
A method, as claimed in claim 1 , wherein said step of operating includes the step of operating the signal generator to provide a burst of electrical energy to initiate movement.
Claim 12
Dependent Claim
30 words
A method, as claimed in claim 1 , wherein said step of operating includes the step of operating the signal generator to pulse at a repetition rate of 2-2500 Hertz.
Claim 13
Dependent Claim
30 words
A method, as claimed in claim 1 , wherein the step of operating includes the step of operating the signal generator to pulse at a repetition rate of 10-2500 Hertz.
Claim 14
Dependent Claim
55 words
A method, as claimed in claim 1 , further comprising the steps of: (d) implanting at least one secondary electrode so that a secondary stimulation portion lies in communication with a predetermined portion of a brain; (e) coupling the secondary electrode to the signal generator; and (f) operating the signal generator to stimulate the brain.
Claim 15
Dependent Claim
53 words
A method, as claimed in claim 1 , further comprising the steps of: (d) implanting at least one catheter so that a secondary stimulation portion lies in communication with a predetermined portion of a brain; (e) coupling the catheter to a pump; and (f) operating the pump to deliver drug to the brain.
Claim 16
Dependent Claim
86 words
A therapeutic treatment method for treating movement disorders by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of at least one drug, the method comprising the steps of: (a) implanting the catheter so that the discharge portion lies in at least direct communication with tissue element of a pedunculopontine nucleus (PPN); (b) coupling the catheter to the pump; and (c) operating the pump to deliver the drug to the PPN.
Claim 17
Dependent Claim
86 words
A therapeutic treatment method for treating movement disorders by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of at least one drug, the method comprising the steps of: (a) implanting the catheter so that the discharge portion lies in at least direct communication with tissue element of a pedunculopontine nucleus (PPN); (b) coupling the catheter to the pump; and (c) operating the pump to deliver the drug to the PPN.
Claim 18
Dependent Claim
55 words
A method, as claimed in claim 15 , wherein the step of operating includes the step of delivering to the PPN at least one drug selected from the group consisting of an anesthetic, a GABA agonist, a GABA antagonist, a glutamate antagonist, a glutamate agonist, a degrading enzyme, a reputake blocker, and a dopamine antagonist.
Claim 19
Dependent Claim
24 words
A method, as claimed in claim 16 , wherein the step of operating includes the step of selecting a time interval for drug delivery.
Claim 20
Dependent Claim
21 words
A method, as claimed in claim 15 , wherein the step of operating includes the step of selecting a drug dosage.
Claim 21
Dependent Claim
40 words
A method, as claimed in claim 15 , further comprising the steps of: (d) sensing the extent of the movement disorder and generating a sensor signal; and (e) regulating the operation of the pump in response to the sensor signal.
Claim 22
Dependent Claim
26 words
A method, as claimed in claim 15 , wherein the step of regulating includes the step of adjusting drug dosage and time interval for drug delivery.
Claim 23
Independent Claim
153 words
A method of using one or more drugs to therapeutically treat a neural disorder over a predetermined time period by means of an implantable pump and a catheter having a proximal end coupled to said pump and a discharge portion for infusing therapeutic dosages of said one or more drugs, as well as a signal generator and an implantable electrode having a proximal end and a stimulation portion, the method comprising the steps of: (a) surgically implanting the electrode so that the stimulation portion lies at least in direct communication with tissue elements of a pedunculopontine nucleus (PPN); (b) surgically implanting said catheter so that the discharge portion lies adjacent a predetermined infusion site in a brain; (c) operating the signal generator to stimulate the PPN; and (d) operating the pump to discharge a predetermined dosage of at least one drug through the discharge portion of the catheter into the predetermined infusion site.
Claim 24
Independent Claim
153 words
A method of using one or more drugs to therapeutically treat a neural disorder over a predetermined time period by means of an implantable pump and a catheter having a proximal end coupled to said pump and a discharge portion for infusing therapeutic dosages of said one or more drugs, as well as a signal generator and an implantable electrode having a proximal end and a stimulation portion, the method comprising the steps of: (a) surgically implanting the electrode so that the stimulation portion lies at least in direct communication with tissue elements of a pedunculopontine nucleus (PPN); (b) surgically implanting said catheter so that the discharge portion lies adjacent a predetermined infusion site in a brain; (c) operating the signal generator to stimulate the PPN; and (d) operating the pump to discharge a predetermined dosage of at least one drug through the discharge portion of the catheter into the predetermined infusion site.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2005-03-11 | 2005-09-10 | 2006-03-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-03-11 | 2009-09-10 | 2010-03-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-03-11 | 2013-09-10 | 2014-03-12 | $7700.00 | Window Closed / Lapsed |