US6355776B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
Assignee: Protein Polymer Technologies Inc
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Filing: 1999-11-22
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Granted: 2002-03-12
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Expires: 2019-11-22
Abstract
Abstract Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
Inventors
- 👤 Franco A. Ferrari
- 👤 Charles Richardson
- 👤 James Chambers
- 👤 Stuart Causey
- 👤 Thomas J. Pollock
- 👤 Joseph Cappello
- 👤 John W. Crissman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 06:00
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/43504; C07K14/43563; C07K14/43586; C07K14/78; C12; C12N; C12N1/00; C12N1/06; C12N15/00; C12N15/09; C12N15/11; C12N15/62; C12N15/63; C12N15/66; C12N15/70; C12N15/74; C12N15/75; C07K2319/00; C07K2319/01; C07K2319/02; C07K2319/33; C07K2319/61
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
47 words
A recombinantly produced protein of from about 30 Kdal to about 250 Kdal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids.
Claim 2
Dependent Claim
47 words
A recombinantly produced protein of from about 30 Kdal to about 250 Kdal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids.
Claim 3
Dependent Claim
25 words
The recombinantly produced protein according to claim 1 , wherein said at least one naturally occurring repeating unit does not form an identical repeating pattern.
Claim 4
Dependent Claim
134 words
The recombinantly produced protein according to claim 1 , wherein said recombinantly produced protein comprises (i) a repeating unit, comprising a silk-like sequence or an elastin-like sequence; and (ii) a repeating unit comprising a sequence selected from the group of sequences consisting of PTTTK (SEQ ID NO:1), AKPSYPPTYK (SEQ ID NO:2), PPVYK (SEQ ID NO:3), xPPP (SEQ ID NO:106), wherein x is any amino acid, TTTPDV (SEQ ID NO:4), GGLGY (SEQ ID NO:5), APAAP (SEQ ID NO:6), PEPK (SEQ ID NO:7), PMPK (SEQ ID NO:8), SPPPP (SEQ ID NO:9), PEPMPK (SEQ ID NO:10), PPVYKPPVQK (SEQ ID NO:11), PPVK (SEQ ID NO:12), PPVEK (SEQ ID NO:13), PGVGV (SEQ ID NO:14), VGVAPG (SEQ ID NO:15), SPPPPSPKYVYK (SEQ ID NO:16), SPPPPYYYKSPPPPSP (SEQ ID NO:17), SPPPPPTPSYGHPKTP (SEQ ID NO:18), SSPPPPSPSPPPPTYYYY (SEQ ID NO:19), and KSPVPKSPVEEKG (SEQ ID NO:20).
Claim 5
Dependent Claim
27 words
The recombinantly produced protein according to claim 1 , wherein said recombinantly produced protein comprises an intervening sequence of from 1-50 amino acids between said repeating units.
Claim 6
Dependent Claim
19 words
The recombinantly produced protein according to claim 4 , wherein said intervening sequence comprises a proteolytic enzyme cleavage seecequence.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2005-03-11 | 2005-09-10 | 2006-03-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-03-11 | 2009-09-10 | 2010-03-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-03-11 | 2013-09-10 | 2014-03-12 | $7700.00 | Window Closed / Lapsed |