US6287320B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
Assignee: Endoluminal Therapeutics Inc
•
Filing: 1997-08-26
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Granted: 2001-09-11
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Expires: 2017-08-26
Abstract
Abstract The present invention provides a technique for treating diseased portions of tissue lumens by the focal introduction of at least one therapeutic agent at the diseased region. A catheter is positioned in a lumen such that first and second expansile members surround the diseased portion of tissue. The expansile members are expanded to occlude the diseased region and a therapeutic agent is introduced to the occluded diseased region via the catheter. The catheter is allowed to remain in place for a therapeutically effective period of time to allow the therapeutic agent to contact the diseased portion for such a period of time. The catheter arrangement also can be used to occlude a diseased region, remove physiological fluid from the occluded region and subsequently to disrupt the diseased region and/or apply the therapeutic agent. The therapeutic agent can be selected to suppress cell proliferation in the diseased region, and the occluded region can be treated with a medicament to promote vessel healing. The occluded region also can be paved with polymeric material. Finally, the expansile members are contracted and the catheter is removed.
Inventors
- 👤 Marvin J. Slepian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:19
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/001; A61L24/0031; A61M; A61M25/00; A61M25/10; A61M25/1011; A61M2025/1043; A61M2025/1052; A61M2025/1095
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
121 words
A method for providing localized therapy with a therapeutic agent to a diseased region in a tissue lumen, comprising: (a) introducing a catheter into the tissue lumen, said catheter comprising first and second expansile members and said catheter being positioned such that said first and second expansile members are disposed on opposite sides of the diseased region; (b) expanding the expansile members to occlude the diseased region of the tissue lumen; (c) introducing a therapeutic agent to the occluded diseased region via the catheter; applying a conforming polymer coating to a surface of the tissue lumen via the catheter; allowing the catheter to remain in place for a therapeutically effective period of time; contracting the expansile members; and removing the catheter.
Claim 2
Independent Claim
121 words
A method for providing localized therapy with a therapeutic agent to a diseased region in a tissue lumen, comprising: (a) introducing a catheter into the tissue lumen, said catheter comprising first and second expansile members and said catheter being positioned such that said first and second expansile members are disposed on opposite sides of the diseased region; (b) expanding the expansile members to occlude the diseased region of the tissue lumen; (c) introducing a therapeutic agent to the occluded diseased region via the catheter; applying a conforming polymer coating to a surface of the tissue lumen via the catheter; allowing the catheter to remain in place for a therapeutically effective period of time; contracting the expansile members; and removing the catheter.
Claim 3
Dependent Claim
20 words
A method as in claim 1 , wherein the polymer coating is applied to the surface from a polymer precursor.
Claim 4
Dependent Claim
30 words
A method as in claim 2 , wherein the precursor is selected from the group consisting of a monomer, a prepolymer solution, and an at least partially preformed polymer product.
Claim 5
Dependent Claim
14 words
A method as in claim 3 , wherein the precursor contains the therapeutic agent.
Claim 6
Dependent Claim
20 words
A method as in claim 3 , wherein the precursor is introduced as an at least partially polymerized, deformable sleeve.
Claim 7
Dependent Claim
24 words
A method as in claim 1 , further comprising the step of washing the occluded region to remove body fluid after the expanding step.
Claim 8
Dependent Claim
32 words
A method as in claim 1 , further comprising the step of disrupting the diseased region of a tissue lumen to loosen diseased tissue after the step of introducing the therapeutic agent.
Claim 9
Dependent Claim
38 words
A method as in claim 1 , wherein the therapeutic agent is selected from the group consisting of anti-thrombotic agents, thrombolytic agents, vasodilating agents, calcium channel blocking drugs, anti-proliferative agents, intercalating agents, gross modulating factors and anti-inflammatory agents.
Claim 10
Dependent Claim
31 words
A method as in claim 1 , wherein the catheter has a distal region adapted for inserting into a patient and a proximal region adapted to remain outside of the patient.
Claim 11
Dependent Claim
47 words
A method as in claim 9 , wherein the step of introducing the therapeutic agent further includes the step of accessing a reservoir of therapeutic agent, the reservoir being situated at the proximal region and connected with a port at the distal region via a fluid pathway.
Claim 12
Dependent Claim
19 words
A method as in claim 10 , wherein the port is located between the first and second expansile members.
Claim 13
Independent Claim
119 words
A method for providing localized therapy with a therapeutic agent to a diseased region in a tissue lumen, comprising: introducing an elongate tubular shaft into the tissue lumen, the shaft having a distal region adapted for inserting into a patient and a proximal region adapted to remain outside of the patient; applying a conforming polymer coating to the diseased region; and adding a therapeutic agent to the diseased region via the shaft for a therapeutically effective period of time, wherein the therapeutic agent is selected to influence the behavior of cells and is selected from the group consisting of anti-thrombotic agents, thrombolytic agents, vasodilating agents, calcium channel blocking drugs, anti-proliferative agents, intercalating agents, gross modulating factors and anti-inflammatory agents.
Claim 14
Independent Claim
119 words
A method for providing localized therapy with a therapeutic agent to a diseased region in a tissue lumen, comprising: introducing an elongate tubular shaft into the tissue lumen, the shaft having a distal region adapted for inserting into a patient and a proximal region adapted to remain outside of the patient; applying a conforming polymer coating to the diseased region; and adding a therapeutic agent to the diseased region via the shaft for a therapeutically effective period of time, wherein the therapeutic agent is selected to influence the behavior of cells and is selected from the group consisting of anti-thrombotic agents, thrombolytic agents, vasodilating agents, calcium channel blocking drugs, anti-proliferative agents, intercalating agents, gross modulating factors and anti-inflammatory agents.
Claim 15
Dependent Claim
27 words
A method as in claim 12 , comprising applying the polymer coating by adding the precursor via the shaft and curing the precursor on the diseased region.
Claim 16
Dependent Claim
22 words
A method as in claim 13 , further comprising the step of occluding the diseased region prior to applying the polymer coating.
Claim 17
Dependent Claim
22 words
A method as in claim 13 , further comprising the step of occluding the diseased region prior to adding the therapeutic agent.
Claim 18
Dependent Claim
20 words
A method as in claim 14 , further comprising the step of removing physiological fluid from the occluded diseased region.
Claim 19
Dependent Claim
29 words
A method as in claim 16 , further comprising the step of disrupting the diseased region of the tissue lumen to loosen diseased tissue after removing the physiological fluid.
Claim 20
Dependent Claim
50 words
A method as in claim 13 , wherein the step of contacting the diseased region with the therapeutic agent includes the step of accessing a reservoir of therapeutic agent, the reservoir being situated at the proximal region and connected with a port at the distal region via a fluid pathway.
Claim 21
Dependent Claim
29 words
A method as in claim 18 , wherein the step of occluding the diseased region involves expanding first and second occlusion elements at the distal region of the shaft.
Claim 22
Dependent Claim
19 words
A method as in claim 19 , wherein the port is located between the first and second occlusion elements.
References Cited (Backward Citations)
US2642874A
Cited
US2854982A
Cited
US3868956A
Cited
US3987000A
Cited
US3880158A
Cited
US4459252A
Cited
US4140126A
Cited
US4156067A
Cited
US4272518A
Cited
US4377011A
Cited
US4520823A
Cited
US4553545A
Cited
US4610662A
Cited
US4573966A
Cited
US4448188A
Cited
US4423725A
Cited
US4636195A
Cited
US4655771B1
Cited
US4655771A
Cited
US4445892A
Cited
US4503569A
Cited
US4560374A
Cited
US4627436A
Cited
US4701509A
Cited
US4580568A
Cited
EP0183372A1
Cited
US4799479A
Cited
US4674506A
Cited
US4763653A
Cited
US4824436A
Cited
US4690684A
Cited
US4781677A
Cited
US4650466A
Cited
US4733665B1
Cited
US4733665C2
Cited
US4733665A
Cited
US4702917A
Cited
US4655746A
Cited
US4832688A
Cited
US4911163A
Cited
US4754752A
Cited
US4744366A
Cited
US4763654A
Cited
US4771777A
Cited
US5059211A
Cited
US4820298A
Cited
WO1989010155A1
Cited
WO1989012478A1
Cited
US5232444A
Cited
WO1990001989A1
Cited
US5213580A
Cited
US5328470A
Cited
US5100429A
Cited
US5147385A
Cited
WO1991007154A1
Cited
US5306249A
Cited
US5460610A
Cited
US5328471A
Cited
WO1991012846A1
Cited
US5279546A
Cited
US5171217A
Cited
US5258042A
Cited
US5306250A
Cited
US5261878A
Cited
US5305286A
Cited
US5462529A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-09-10 | 2005-03-12 | 2005-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-09-10 | 2009-03-12 | 2009-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-09-10 | 2013-03-12 | 2013-09-11 | $7700.00 | Window Closed / Lapsed |