US6232064B1
Expired / Lapsed
US
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Methods of diagnosing a pathology characterized by a cell proliferative disorder associated with connective tissue growth factor
Assignee: University of South Florida St. Petersburg
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Filing: 1998-03-30
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Granted: 2001-05-15
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Expires: 2018-03-30
Abstract
Abstract The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-beta responsive element upstream of the polynucleotide encoding CTGF structural gene.
Inventors
- 👤 Gary R. Grotendorst
- 👤 Douglass M. Bradham, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:16
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1841; A61K38/39; A61P; A61P11/00; A61P13/00; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P19/04; A61P27/00; A61P27/02; A61P27/06; A61P35/00; A61P43/00; A61P9/00; A61P9/10; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0652; C12N5/0655
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
116 words
A method of diagnosing a pathological state in a subject suspected of having a pathology selected from the group consisting of fibrotic disease and atherosclerosis, the method comprising: obtaining a sample suspected of containing connective tissue growth factor (CTGF) from the subject; determining the level of CTGF in the sample; and comparing the level of CTGF in the sample from the subject to the level of CTGF in a normal standard sample, whereby detecting a difference in the level of CTGF in the sample from the subject as compared to the level of CTGF in the normal standard sample is diagnostic of a pathology characterized by a cell proliferative disorder associated with CTGF in the subject.
Claim 2
Independent Claim
116 words
A method of diagnosing a pathological state in a subject suspected of having a pathology selected from the group consisting of fibrotic disease and atherosclerosis, the method comprising: obtaining a sample suspected of containing connective tissue growth factor (CTGF) from the subject; determining the level of CTGF in the sample; and comparing the level of CTGF in the sample from the subject to the level of CTGF in a normal standard sample, whereby detecting a difference in the level of CTGF in the sample from the subject as compared to the level of CTGF in the normal standard sample is diagnostic of a pathology characterized by a cell proliferative disorder associated with CTGF in the subject.
Claim 3
Dependent Claim
37 words
The method of claim 1 , wherein determining the level of CTGF in the sample comprises using an antibody that is specifically reactive with CTGF or a fragment thereof, or an antigen binding fragment of said antibody.
Claim 4
Dependent Claim
31 words
The method of claim 1 , wherein determining the level of CTGF in the sample comprises using a nucleic acid probe which specifically hybridizes to a nucleic acid molecule encoding CTGF.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-05-14 | 2004-11-13 | 2005-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-05-14 | 2008-11-13 | 2009-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-05-14 | 2012-11-13 | 2013-05-15 | $7700.00 | Window Closed / Lapsed |