US5408040A
Expired / Lapsed
US
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Connective tissue growth factor(CTGF)
Assignee: University of South Florida St. Petersburg
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Filing: 1993-12-14
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Granted: 1995-04-18
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Expires: 2013-12-14
Abstract
Abstract A novel chemotactic and mitogenic protein, Connective Tissue Growth Factor (CTGF), a polynucleotide that encodes CTGF and antibodies that bind to CTGF are provided. Diagnostic and therapeutic methods using CTGF are also described.
Inventors
- 👤 Gary R. Grotendorst
- 👤 Douglas M. Bradham, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:06
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/22; C07K14/00; C07K14/435; C07K14/475; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
63 words
Substantially pure connective tissue growth factor (CTGF) polypeptide, wherein the polypeptide is characterized by: (a) mitogenic and chemotactic activity for connective tissue cells; (b) a molecular weight of approximately 36 kD by non-reducing SDS-PAGE and approximately 38 kD by reducing SDS-PAGE; (c) binding to a PDGF receptor; (d) existing as a monomer; and (e) a polypeptide sequence according to Sequence ID No. 2.
Claim 2
Dependent Claim
63 words
Substantially pure connective tissue growth factor (CTGF) polypeptide, wherein the polypeptide is characterized by: (a) mitogenic and chemotactic activity for connective tissue cells; (b) a molecular weight of approximately 36 kD by non-reducing SDS-PAGE and approximately 38 kD by reducing SDS-PAGE; (c) binding to a PDGF receptor; (d) existing as a monomer; and (e) a polypeptide sequence according to Sequence ID No. 2.
Claim 3
Dependent Claim
17 words
Antibodies which bind the CTGF polypeptide of Sequence ID No.2, but not platelet derived growth factor (PDGF).
Claim 4
Dependent Claim
17 words
Antibodies which bind the CTGF polypeptide of Sequence ID No.2, but not platelet derived growth factor (PDGF).
Claim 5
Dependent Claim
10 words
The antibodies of claim 2, wherein the antibodies are polyclonal.
Claim 6
Dependent Claim
10 words
The antibodies of claim 2, wherein the antibodies are monoclonal.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-04-17 | 1998-10-17 | 1999-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-17 | 2002-10-17 | 2003-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-17 | 2006-10-17 | 2007-04-18 | $7700.00 | Window Closed / Lapsed |