US6203755B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electron beam sterilization of biological tissues
Assignee: St Jude Medical LLC
•
Filing: 1994-03-04
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Granted: 2001-03-20
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Expires: 2014-03-04
Abstract
Abstract The invention involves a method for sterilizing biological tissues. The invention also includes sterilized biological tissues.
Inventors
- 👤 Thomas L. Odland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:08
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61L2/08; A61L2/087; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/24; A61L2/081; A61L2103/00; A61L2103/05; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/918
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
21 words
A sterilized collagen-containing biological tissue suitable for implantation comprising a crosslinked, hydrated collagen-containing tissue irradiated with a beam of accelerated electrons.
Claim 2
Dependent Claim
21 words
A sterilized collagen-containing biological tissue suitable for implantation comprising a crosslinked, hydrated collagen-containing tissue irradiated with a beam of accelerated electrons.
Claim 3
Dependent Claim
14 words
The tissue of claim 1 wherein said crosslinked tissue has been crosslinked by glutaraldehyde.
Claim 4
Dependent Claim
25 words
A packaged sterilized collagen-containing biological tissue suitable for implantation comprising a crosslinked, hydrated collagen-containing biological tissue sealed in a container and exposed to electron-beam radiation.
Claim 5
Dependent Claim
25 words
A packaged sterilized collagen-containing biological tissue suitable for implantation comprising a crosslinked, hydrated collagen-containing biological tissue sealed in a container and exposed to electron-beam radiation.
Claim 6
Dependent Claim
79 words
A collagen-containing biological tissue suitable for implantation wherein said biological tissue comprises tissue irradiated with a beam of accelerated electrons, and wherein said biological tissue has at least one improved performance characteristic relative to a tissue not irradiated with accelerated electrons, and wherein said improved performance characteristic is selected from the group consisting of greater softness, greater kink resistance, improved suturability, greater tensile strength, no loss of tensile strength, increased effective orifice area, decreased pressure gradients, and enhanced durability.
Claim 7
Dependent Claim
79 words
A collagen-containing biological tissue suitable for implantation wherein said biological tissue comprises tissue irradiated with a beam of accelerated electrons, and wherein said biological tissue has at least one improved performance characteristic relative to a tissue not irradiated with accelerated electrons, and wherein said improved performance characteristic is selected from the group consisting of greater softness, greater kink resistance, improved suturability, greater tensile strength, no loss of tensile strength, increased effective orifice area, decreased pressure gradients, and enhanced durability.
Claim 8
Dependent Claim
21 words
The tissue of claim 1 wherein said tissue has been irradiated at a dose rate of approximately 7800 grays per minute.
Claim 9
Dependent Claim
21 words
The tissue of claim 3 wherein said tissue has been irradiated at a dose rate of approximately 7800 grays per minute.
Claim 10
Dependent Claim
14 words
The tissue of claim 1 wherein said irradiated biological tissue is not significantly degraded.
Claim 11
Dependent Claim
10 words
The tissue of claim 1 further comprising an anti-calcification agent.
Claim 12
Dependent Claim
9 words
The tissue of claim 1 further comprising a radio-protectant.
Claim 13
Dependent Claim
23 words
The tissue of claim 1 wherein said biological, tissue comprises a heart valve, aortic root, heart valve leaflet, vascular prosthesis or pericardial tissue.
Claim 14
Dependent Claim
15 words
The packaged tissue of claim 3 wherein the irradiated biological tissue is not significantly degraded.
Claim 15
Dependent Claim
11 words
The packaged tissue of claim 3 further comprising an anticalcification agent.
Claim 16
Dependent Claim
10 words
The packaged tissue of claim 3 further comprising a radioprotectant.
Claim 17
Dependent Claim
24 words
The packaged tissue of claim 3 wherein said biological tissue comprises a heart valve, aortic root, heart valve leaflet, vascular prosthesis or pericardial tissue.
Claim 18
Dependent Claim
23 words
The tissue of claim 4 wherein said biological tissue comprises a heart valve, aortic root, heart valve leaflet, vascular prosthesis or pericardial tissue.
Claim 19
Dependent Claim
13 words
The tissue of claim 4 wherein said improved performance characteristic is greater softness.
Claim 20
Dependent Claim
14 words
The tissue of claim 4 wherein said improved performance characteristic is greater tensile strength.
Claim 21
Dependent Claim
13 words
The tissue of claim 4 wherein said improved performance characteristic is enhanced durability.
Claim 22
Dependent Claim
25 words
The tissue of claim 4 wherein said biological tissue has a plurality of improved performance characteristic comprising greater softness, greater tensile strength and enhanced durability.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-03-19 | 2004-09-18 | 2005-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-03-19 | 2008-09-18 | 2009-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-03-19 | 2012-09-18 | 2013-03-20 | $7700.00 | Window Closed / Lapsed |