US4456589A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of animal tissues for surgical implantation in human recipients
Assignee: Bio Vascular Inc
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Filing: 1982-07-08
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Granted: 1984-06-26
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Expires: 2002-07-08
Abstract
Abstract A process for treating animal tissue to make it acceptable for implantation in a human recipient without rejection or reabsorption, the process including the step of tanning the cartilage chemically or by irradiation: a preliminary dehydration step and a subsequent step of storage in an anti-microbial medium may also be used.
Inventors
- 👤 Daniel G. Holman
- 👤 Arthur A. Beisang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:32
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3612; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61K; A61K35/00; A61K35/12; A61K35/32; A61K35/44; A61L27/3683; A61L27/3687; A61L2430/00; A61L2430/40; Y; Y10; Y10S; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
27 words
The method of preparing animal cartilage for implant use in plastic or reconstructive surgery on human subjects which includes the step of chemically tanning cleansed, dehydrated cartilage.
Claim 2
Independent Claim
27 words
The method of preparing animal cartilage for implant use in plastic or reconstructive surgery on human subjects which includes the step of chemically tanning cleansed, dehydrated cartilage.
Claim 3
Dependent Claim
12 words
The method of claim 1 in which the tanning agent is glutaradehyde.
Claim 4
Dependent Claim
13 words
The method of claim 1 in which the chemical agent is dialdyhyde starch.
Claim 5
Dependent Claim
31 words
The method of claim 1 including the further step of rinsing the tanned material in saline solution and storing it in an anti-microbial medium made up of ethanol and propylene oxide.
Claim 6
Dependent Claim
26 words
The method of claim 4 in which the anti-microbial medium comprises 99 parts by volume of 70% ethanol and one part by volume of propylene oxide.
Claim 7
Independent Claim
89 words
The method of treating animal tissue which has been freed of adipose tissue, comprising the steps of: (a) dehydrating the tissue by immersion for at least 72 hours in 95% ethanol; (b) rinsing the tissue in sterile deionized water; (c) tanning the tissue by immersion for at least 48 hours in 0.25% glutaraldehyde; (d) rinsing the tissue in 0.9% saline solution; and (e) storing the tissue at room temperature in an antimicrobial medium of 99 parts by volume of 70% ethanol and 1 part by volume of propylene oxide.
Claim 8
Independent Claim
89 words
The method of treating animal tissue which has been freed of adipose tissue, comprising the steps of: (a) dehydrating the tissue by immersion for at least 72 hours in 95% ethanol; (b) rinsing the tissue in sterile deionized water; (c) tanning the tissue by immersion for at least 48 hours in 0.25% glutaraldehyde; (d) rinsing the tissue in 0.9% saline solution; and (e) storing the tissue at room temperature in an antimicrobial medium of 99 parts by volume of 70% ethanol and 1 part by volume of propylene oxide.
Claim 9
Independent Claim
40 words
The method of treating animal tissue which has been freed of adipose tissue, comprising the steps of dehydrating the tissue, first rinsing the tissue, tanning the tissue, again rinsing the tanned tissue, and storing the tanned tissue at room temperature.
Claim 10
Independent Claim
40 words
The method of treating animal tissue which has been freed of adipose tissue, comprising the steps of dehydrating the tissue, first rinsing the tissue, tanning the tissue, again rinsing the tanned tissue, and storing the tanned tissue at room temperature.
Claim 11
Dependent Claim
12 words
The method of claim 7 in which the tissue is nasal cartilage.
Claim 12
Dependent Claim
12 words
The method of claim 7 in which the tissue is costal cartilage.
Claim 13
Dependent Claim
11 words
The method of claim 7 in which the tissue is pericardium.
Claim 14
Dependent Claim
16 words
The method of claim 7 in which the dehydration is accomplished by immersion in 95% ethanol.
Claim 15
Dependent Claim
22 words
The method of claim 7 in which the dehydration is accomplished by immersion for at least about 72 hours in 95% ethanol.
Claim 16
Dependent Claim
16 words
The method of claim 7 in which the tissue is first rinsed in sterile deionized water.
Claim 17
Dependent Claim
16 words
The method of claim 7 in which the tissue is rinsed in sterile 0.9% saline solution.
Claim 18
Dependent Claim
14 words
The method of claim 7 in which the tissue is stored in saline solution.
Claim 19
Dependent Claim
15 words
The method of claim 7 in which the tissue is stored in an anti-microbial medium.
Claim 20
Dependent Claim
26 words
The method of claim 16 in which the anti-microbial medium is 99 parts by volume of 70% ethanol and 1 part by volume of propylene oxide.
Claim 21
Dependent Claim
16 words
The method of claim 16 in which the anti-microbial medium includes a source of silver ions.
Claim 22
Dependent Claim
13 words
The method of claim 18 in which the anti-microbial medium includes silver nitrate.
Claim 23
Dependent Claim
13 words
The method of claim 18 in which the anti-microbial medium includes silver sulfadiazine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-26 | 1987-12-26 | 1988-06-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-26 | 1991-12-26 | 1992-06-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-26 | 1995-12-26 | 1996-06-26 | $7700.00 | Window Closed / Lapsed |