US6166092A
Expired / Lapsed
US
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Fluorocarbon compositions for pulmonary therapy
Assignee: Temple University
•
Filing: 1995-06-07
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Granted: 2000-12-26
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Expires: 2015-06-07
Abstract
Abstract Biocompatible fluorocarbon compositions are provided which may be used for the delivery of bioactive agents to the pulmonary air passages of a patient. Preferred compositions comprise a fluorocarbon liquid carrier having a bioactive agent in a solid or immiscible liquid form distributed therein. The disclosed compositions allow for the selective delivery of bioactive agents in conjunction with liquid lavage and liquid ventilation for the treatment of ARDS and other pulmonary disorders.
Inventors
- 👤 K. Michael Sekins
- 👤 Thomas H. Shaffer
- 👤 Marla R. Wolfson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61F; A61F7/00; A61F7/12; A61F7/123; A61M; A61M16/00; A61M16/04; A61M16/0402; A61M16/0404; A61M16/0434; A61M16/0454; A61M16/0459; A61M16/0463; A61M16/0475; A61M16/0477; A61M16/0479; A61M16/0486; A61N; A61N7/00; A61N7/02; A61N7/022; B; B06; B06B; B06B1/00; B06B1/02; B06B1/06; B06B1/0607; B06B1/0622; B06B1/0633; A61B; A61B17/00; A61B17/22; A61B2017/22051; A61B2017/22054; A61B18/00; A61B2018/00005; A61B2018/00011; A61F2007/0054; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/33; A61M2205/3368; Y; Y10; Y10S; Y10S128/00; Y10S128/913; Y10T; Y10T137/00; Y10T137/8593; Y10T137/87571; Y10T137/87652
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
59 words
A composition for direct pulmonary delivery of at least one therapeutic or diagnostic a biological agent to at least a portion of the air passages of a patient comprising a biocompatible perfluorochemical liquid carrier having a boiling point greater than about 55° having distributed therein at least one biological agent in the form of a solid or immiscible liquid.
Claim 2
Dependent Claim
59 words
A composition for direct pulmonary delivery of at least one therapeutic or diagnostic a biological agent to at least a portion of the air passages of a patient comprising a biocompatible perfluorochemical liquid carrier having a boiling point greater than about 55° having distributed therein at least one biological agent in the form of a solid or immiscible liquid.
Claim 3
Dependent Claim
44 words
A composition according to claim 1 wherein said solid or liquid biological agent is selected from the group consisting of anti-cancer agents, antibiotics, bronchoconstrictors, bronchodilators, antibody-linked radionuclides, vasoconstrictors, vasodilators, surfactants, steroids, chemotactic agents, chemotherapeutic agents, contrast agents, antioxidants and antiproteases, or a combination thereof.
Claim 4
Dependent Claim
13 words
A composition according to claim 1 wherein said perfluorochemical liquid carrier is oxygenated.
Claim 5
Dependent Claim
29 words
A composition according to claim 1 wherein said perfluorochemical liquid carrier comprises a fluorocarbon having an average molecular weight in the range of from about 350 to 560 daltons.
Claim 6
Dependent Claim
27 words
A composition according to claim 1 wherein said perfluorochemical liquid carrier comprises a fluorocarbon having a vapor pressure of less than about 200 Torr at 25° C.
Claim 7
Dependent Claim
24 words
A composition according to claim 1 wherein said perfluorochemical liquid carrier comprises a fluorocarbon having O 2 solubility greater than about 40 ml/100 ml.
Claim 8
Dependent Claim
21 words
The composition of claim 1 wherein said perfluorochemical liquid carrier is at a temperature below the body temperature of the patient.
Claim 9
Dependent Claim
21 words
The composition of claim 1 wherein said perfluorochemical liquid carrier is at a temperature above the body temperature of the patient.
Claim 10
Dependent Claim
14 words
The composition of claim 1 wherein said biological agent is in a powder form.
Claim 11
Dependent Claim
41 words
The composition of claim 7 wherein said biological agent is selected from the group consisting of antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents, antioxidants and antiproteases, or a combination thereof.
Claim 12
Dependent Claim
17 words
The composition of claim 1 wherein said biological agent is in the form of an immiscible liquid.
Claim 13
Dependent Claim
21 words
The composition of claim 11 wherein said immiscible liquid biological agent comprises the therapeutic or diagnostic agent in a liquid phase.
Claim 14
Dependent Claim
11 words
The composition of claim 12 wherein said liquid phase is aqueous.
Claim 15
Dependent Claim
43 words
The composition of claim 12 wherein said therapeutic or diagnostic agent is selected from the group consisting of antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents, antioxidants and antiproteases, or a combination thereof.
Claim 16
Dependent Claim
34 words
The composition of claim 2 wherein said perfluorochemical liquid carrier is selected from the group consisting of FC-84, FC-72, RM-82, FC-75, RM-101, FC-43, RM-175, FC-5311, FC-5312, trimethylbicyclononane, dimethyladamantine and perfluorodecalin, or a combination thereof.
Claim 17
Dependent Claim
68 words
A composition for the direct pulmonary delivery of at least one therapeutic or diagnostic biological agent to at least a portion of the air passages of a patient comprising a biocompatible perfluorochemical liquid carrier having a vapor pressure of less than about 200 Torr at 25° C. said perfluorochemical liquid carrier having at least one biological agent in the form of a solid or immiscibler liquid dispersed therein.
Claim 18
Dependent Claim
68 words
A composition for the direct pulmonary delivery of at least one therapeutic or diagnostic biological agent to at least a portion of the air passages of a patient comprising a biocompatible perfluorochemical liquid carrier having a vapor pressure of less than about 200 Torr at 25° C. said perfluorochemical liquid carrier having at least one biological agent in the form of a solid or immiscibler liquid dispersed therein.
Claim 19
Dependent Claim
41 words
The composition of claim 16 wherein said biological agent is selected from the group consisting of antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents, antioxidants, and antiproteases, or a combination thereof.
Claim 20
Dependent Claim
21 words
The composition of claim 16 wherein said perfluorochemical liquid carrier is at a temperature below the body temperature of the patient.
Claim 21
Dependent Claim
21 words
The composition of claim 16 wherein said perfluorochemical liquid carrier is at a temperature above the body temperature of the patient.
Claim 22
Dependent Claim
15 words
The composition of claim 16 wherein said solid biological agent is in a powder form.
Claim 23
Dependent Claim
41 words
The composition of claim 20 wherein said biological agent is selected from the group consisting of antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents, antioxidants, and antiproteases, or a combination thereof.
Claim 24
Dependent Claim
17 words
The composition of claim 16 wherein said biological agent is in the form of an immiscible liquid.
Claim 25
Dependent Claim
20 words
The composition of claim 22 wherein said liquid biological agent comprises the therapeutic or diagnostic agent in a liquid phase.
Claim 26
Dependent Claim
11 words
The composition of claim 23 wherein said liquid phase is aqueous.
Claim 27
Dependent Claim
43 words
The composition of claim 23 wherein said therapeutic or diagnostic agent is selected from the group consisting of antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents, antioxidants, and antiproteases, or a combination thereof.
Claim 28
Dependent Claim
34 words
The composition of claim 16 wherein said perfluorochemical liquid carrier is selected from the group consisting of FC-84, FC-72, RM-82, FC-75, RM-101, FC-43, RM-175, FC-5311, FC-5312, trimethylbicyclononane, dimethyladamantine and perfluorodecalin, or a combination thereof.
Claim 29
Dependent Claim
12 words
The composition of claim 16 wherein said perfluorochemical liquid carrier is oxygenated.
Claim 30
Dependent Claim
52 words
A liquid composition for direct pulmonary administration of at least one therapeutic or diagnostic biological agent to at least a portion of the air passages of a patient in need thereof comprising a biocompatible perfluorochemical liquid carrier having a boiling point greater than aboout 55° having a solid biological agent dispersed therein.
Claim 31
Dependent Claim
52 words
A liquid composition for direct pulmonary administration of at least one therapeutic or diagnostic biological agent to at least a portion of the air passages of a patient in need thereof comprising a biocompatible perfluorochemical liquid carrier having a boiling point greater than aboout 55° having a solid biological agent dispersed therein.
Claim 32
Dependent Claim
13 words
A composition according to claim 28 wherein said perfluorochemical liquid carrier is oxygenated.
Claim 33
Dependent Claim
29 words
A composition according to claim 28 wherein said perfluorochemical liquid carrier comprises a fluorocarbon having an average molecular weight in the range of from about 350 to 560 daltons.
Claim 34
Dependent Claim
27 words
A composition according to claim 28 wherein said fluorocarbon liquid carrier comprises a perfluorochemical having a vapor pressure of less than about 200 Torr at 25° C.
Claim 35
Dependent Claim
24 words
A composition according to claim 28 wherein said fluorocarbon liquid carrier comprises a perfluorochemical having O 2 solubility greater than about 40 ml/100 ml.
Claim 36
Dependent Claim
21 words
The composition of claim 28 wherein said perfluorochemical liquid carrier is at a temperature below the body temperature of the patient.
Claim 37
Dependent Claim
21 words
The composition of claim 28 wherein said perfluorochemical liquid carrier is at a temperature above the body temperature of the patient.
Claim 38
Dependent Claim
41 words
The composition of claim 28 wherein said biological agent is selected from the group consisting of antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents, antioxidants and antiproteases, or a combination thereof.
Claim 39
Dependent Claim
34 words
The composition of claim 28 wherein said perfluorochemical liquid carrier is selected from the group consisting of FC-84, FC-72, RM-82, FC-75, RM-101, FC-43, RM-175, FC-5311, FC-5312, trimethylbicyclononane, dimethyladamantine and perfluorodecalin, or a combination thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-12-26 | 2004-06-26 | 2004-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-12-26 | 2008-06-26 | 2008-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-12-26 | 2012-06-26 | 2012-12-26 | $7700.00 | Window Closed / Lapsed |