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US6117166A
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Apparatus and methods for grafting blood vessel tissue
Assignee: Individual
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Filing: 1997-10-27
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Granted: 2000-09-12
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Expires: 2017-10-27
Abstract
Abstract Apparatus and methods especially useful for facilitating grafting of healthy blood vessel tissue onto the internal wall of a blood vessel are described. In one embodiment, the apparatus includes a vascular graft secured to an expandable, wire mesh endovascular stent. The vascular graft is a partial thickness section taken through the thickness of the graft donor tissue and includes the intimal layer composed of endothelial cells. The partial thickness section facilitates regeneration of an endothelial cell layer. The vascular graft may be an autograft or homograft, and may have been prepared earlier and cryogenically frozen. The combination of stent and vascular graft is inserted into a blood vessel having damage to an internal wall. The stent is expanded in position at the site of damage, and the vascular graft grafts onto the damaged internal wall of the blood vessel while being supported by the stent. The stent also provides structural support for the blood vessel wall. The stent may be expanded with a balloon catheter inserted through the lumen of the stent. Alternate embodiments employ a variety of expandable and self-expanding endovascular stents.
Inventors
- 👤 Thomas R. Winston
- 👤 John M. Neet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:08
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/90; A61F2/02; A61F2/04; A61F2/06; A61F2/92; A61F2/95; A61F2/958; A61F2210/00; A61F2210/0076; A61F2220/00; A61F2220/0025; A61F2220/0066; A61F2220/0075
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
88 words
Apparatus comprising: an endovascular stent; and a vascular graft comprising a first partial thickness section of a full thickness of blood vessel tissue, the blood vessel tissue having an intimal layer, a medial layer and an adventitial layer, wherein said first partial thickness section comprises at least a portion of the intimal layer wherein at least a portion of the adventitial layer has been removed and a second partial thickness section includes at least a portion of the adventitial layer, said vascular graft positioned against said endovascular stent.
Claim 2
Dependent Claim
88 words
Apparatus comprising: an endovascular stent; and a vascular graft comprising a first partial thickness section of a full thickness of blood vessel tissue, the blood vessel tissue having an intimal layer, a medial layer and an adventitial layer, wherein said first partial thickness section comprises at least a portion of the intimal layer wherein at least a portion of the adventitial layer has been removed and a second partial thickness section includes at least a portion of the adventitial layer, said vascular graft positioned against said endovascular stent.
Claim 3
Dependent Claim
22 words
Apparatus in accordance with claim 1 wherein said first partial thickness section further comprises at least a portion of the adventitial layer.
Claim 4
Dependent Claim
16 words
Apparatus in accordance with claim 1 wherein said endovascular stent comprises an expandable wire mesh stent.
Claim 5
Dependent Claim
21 words
Apparatus in accordance with claim 1 wherein said endovascular stent is expandable and comprises a thin flexible sheet having perforations therethrough.
Claim 6
Dependent Claim
13 words
Apparatus in accordance with claim 1 wherein said vascular graft comprises meshed tissue.
Claim 7
Dependent Claim
19 words
Apparatus in accordance with claim 1 wherein said vascular graft comprises a plurality of strips of blood vessel tissue.
Claim 8
Dependent Claim
13 words
Apparatus in accordance with claim 1 wherein said vascular graft comprises autograft tissue.
Claim 9
Dependent Claim
13 words
Apparatus in accordance with claim 7 wherein said vascular graft comprises arterial tissue.
Claim 10
Dependent Claim
13 words
Apparatus in accordance with claim 7 wherein said vascular graft comprises venous tissue.
Claim 11
Dependent Claim
13 words
Apparatus in accordance with claim 1 wherein said vascular graft comprises homograft tissue.
Claim 12
Dependent Claim
14 words
Apparatus in accordance with claim 10 wherein said vascular graft has been cryogenically frozen.
Claim 13
Dependent Claim
21 words
Apparatus in accordance with claim 1 further comprising a plurality of surgical sutures securing said vascular graft to said endovascular stent.
Claim 14
Dependent Claim
21 words
Apparatus in accordance with claim 1 further comprising a plurality of surgical staples securing said vascular graft to said endovascular stent.
Claim 15
Dependent Claim
17 words
Apparatus in accordance with claim 1 wherein said endovascular stent is a balloon-expandable stent having a lumen.
Claim 16
Dependent Claim
19 words
Apparatus in accordance with claim 14 further comprising a balloon catheter inserted through the lumen of said balloon-expandable stent.
Claim 17
Dependent Claim
15 words
Apparatus in accordance with claim 1 wherein said stent is a self-expanding roll type stent.
Claim 18
Independent Claim
110 words
A method comprising the steps of: obtaining a tubular section of blood vessel; making a longitudinal cut through a wall of the tubular section forming a sheet of full thickness blood vessel tissue having an intimal layer, a medial layer and an adventitial layer; forming a first partial thickness section and a second partial thickness section, wherein the first partial thickness section comprises at least a portion of the intimal layer, the first partial thickness section forming a vascular graft wherein at least a portion of the adventitial layer has been removed; positioning the vascular graft against an expandable endovascular stent; and securing the vascular graft to the endovascular stent.
Claim 19
Independent Claim
110 words
A method comprising the steps of: obtaining a tubular section of blood vessel; making a longitudinal cut through a wall of the tubular section forming a sheet of full thickness blood vessel tissue having an intimal layer, a medial layer and an adventitial layer; forming a first partial thickness section and a second partial thickness section, wherein the first partial thickness section comprises at least a portion of the intimal layer, the first partial thickness section forming a vascular graft wherein at least a portion of the adventitial layer has been removed; positioning the vascular graft against an expandable endovascular stent; and securing the vascular graft to the endovascular stent.
Claim 20
Dependent Claim
33 words
A method in accordance with claim 17 wherein forming the first partial thickness section comprises the step of forming a second partial thickness section including at least a portion of the adventitial layer.
Claim 21
Dependent Claim
23 words
A method in accordance with claim 17 further comprising the step of securing the vascular graft to the endovascular stent using surgical sutures.
Claim 22
Dependent Claim
23 words
A method in accordance with claim 17 further comprising the step of securing the vascular graft to the endovascular stent using surgical staples.
Claim 23
Dependent Claim
28 words
A method in accordance with claim 17 wherein forming the first partial thickness section comprises the step of forming a solid sheet from the first partial thickness section.
Claim 24
Dependent Claim
21 words
A method in accordance with claim 17 further comprising the step of forming a mesh from the first partial thickness section.
Claim 25
Dependent Claim
27 words
A method in accordance with claim 17 further comprising the step of forming a plurality of strips from the first partial thickness section of blood vessel tissue.
Claim 26
Dependent Claim
48 words
A method in accordance with claim 17, further comprising the steps of: inserting the endovascular stent in combination with the vascular graft into a blood vessel having an internal wall; and expanding the stent so that the vascular graft grafts to the internal wall of the blood vessel.
Claim 27
Dependent Claim
47 words
A method in accordance with claim 24 wherein providing a stent comprises the step of providing a balloon expandable stent and wherein expanding the stent comprises the step of expanding the balloon expandable stent to support the vascular graft against the internal wall of the blood vessel.
Claim 28
Dependent Claim
52 words
A method in accordance with claim 24 wherein providing a stent comprises the step of providing a self-expanding roll type stent and wherein expanding the stent comprises the step of allowing the self-expanding roll type stent to expand and to press the vascular graft against the internal wall of the blood vessel.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-09-12 | 2004-03-13 | 2004-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-09-12 | 2008-03-13 | 2008-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-09-12 | 2012-03-13 | 2012-09-12 | $7700.00 | Window Closed / Lapsed |