US5882354A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Close vascularization implant material
Assignee: Baxalta GmbH
•
Filing: 1995-06-07
•
Granted: 1999-03-16
•
Expires: 2015-06-07
Abstract
Abstract A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.
Inventors
- 👤 James H. Brauker
- 👤 Robert C. Johnson
- 👤 Laura A. Martinson
- 👤 Ronald S. Hill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 13:48
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; A61F; A61F2/00; A61F2/02; A61F2/022; A61L27/00; A61L27/36; A61L27/38; A61L27/3839; A61L27/50; A61L27/56; A61L29/005; A61L29/14; A61L29/146; A61B; A61B5/00; A61B5/145; A61B5/14532; A61B5/41; A61B5/413; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/924; Y10S623/925
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
188 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a second zone of a material defining a chamber wherein the material is permeable to the flow of nutrients from the host to living cells and products from the living cells to the host and impermeable to host immune cells; and (b) a first zone of porous material outside of the second zone of material having a nominal pore size from about 0.6 to about 20 microns which comprises frames of elongated strands of material that are less than 5 microns in all but the longest dimension wherein said frames define apertures which interconnect to form three-dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology, wherein the first zone promotes vascularization adjacent but not substantially into the first zone upon implantation into the host, and wherein the porous material is selected from the group consisting of polyethylene, polypropylene, polytetrafluoroethylene (PTFE), cellulose acetate, cellulose nitrate, polycarbonate, polyester, nylon, polysulfone, mixed esters of cellulose, polyvinylidene difluoride, silicone, and polyacrylonitrile.
Claim 2
Independent Claim
188 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a second zone of a material defining a chamber wherein the material is permeable to the flow of nutrients from the host to living cells and products from the living cells to the host and impermeable to host immune cells; and (b) a first zone of porous material outside of the second zone of material having a nominal pore size from about 0.6 to about 20 microns which comprises frames of elongated strands of material that are less than 5 microns in all but the longest dimension wherein said frames define apertures which interconnect to form three-dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology, wherein the first zone promotes vascularization adjacent but not substantially into the first zone upon implantation into the host, and wherein the porous material is selected from the group consisting of polyethylene, polypropylene, polytetrafluoroethylene (PTFE), cellulose acetate, cellulose nitrate, polycarbonate, polyester, nylon, polysulfone, mixed esters of cellulose, polyvinylidene difluoride, silicone, and polyacrylonitrile.
Claim 3
Independent Claim
135 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a second zone defining a chamber which is permeable to the flow of nutrients from the host to cells and products from the cells to the host and impermeable to host immune cells; and (b) a first zone outside of the second zone which comprises frames of elongated strands of material that are less than 5 microns in all but the longest dimension wherein said frames define apertures which interconnect to form three-dimensional cavities with interconnected apertures which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology, and wherein the first zone promotes vascularization adjacent but not substantially into the first zone upon implantation into the host.
Claim 4
Independent Claim
135 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a second zone defining a chamber which is permeable to the flow of nutrients from the host to cells and products from the cells to the host and impermeable to host immune cells; and (b) a first zone outside of the second zone which comprises frames of elongated strands of material that are less than 5 microns in all but the longest dimension wherein said frames define apertures which interconnect to form three-dimensional cavities with interconnected apertures which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology, and wherein the first zone promotes vascularization adjacent but not substantially into the first zone upon implantation into the host.
Claim 5
Dependent Claim
41 words
The device according to claim 2, wherein the second zone comprises a porous material selected from the group consisting of polyethylene, polypropylene, polytetrafluoroethylene (PTFE), cellulose acetate, cellulose nitrate, polycarbonate, polyester, nylon, polysulfone, mixed esters of cellulose, polyvinylidene difluoride, silicone, and polyacrylonitrile.
Claim 6
Dependent Claim
24 words
The device according to claim 3, wherein the second zone comprises porous material having a nominal porous size about 0.6 to about 20 microns.
Claim 7
Independent Claim
18 words
The device according to claims 1 or 2, wherein said second zone is further impermeable to immune factors.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-03-15 | 2002-09-14 | 2003-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-03-15 | 2006-09-14 | 2007-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-03-15 | 2010-09-14 | 2011-03-16 | $7700.00 | Window Closed / Lapsed |