Patent US6090933A successfully refreshed from Google Patents.
US6090933A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of attaching conductive oligomers to electrodes
Assignee: CLINICAL MICROSENSORS Inc
•
Filing: 1997-08-14
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Granted: 2000-07-18
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Expires: 2017-08-14
Abstract
Abstract The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
Inventors
- 👤 Jon Faiz Kayyem
- 👤 Stephen D. O'Connor
- 👤 Michael Gozin
- 👤 Changjun Yu
- 👤 Thomas J. Meade
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 03:03
CPC Classifications
C; C07; C07H; C07H21/00; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6816; C12Q1/6825
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
52 words
A method for attaching a conductive oligomer to a gold electrode comprising: (a) providing a conductive olizomer with at least a first subunit comprising a sulfur atom protected by a protective group selected from the group consisting of ethyl pyridine or trimethylsilylethyl; and (b) attaching said sulfur atom to said gold electrode.
Claim 2
Independent Claim
52 words
A method for attaching a conductive oligomer to a gold electrode comprising: (a) providing a conductive olizomer with at least a first subunit comprising a sulfur atom protected by a protective group selected from the group consisting of ethyl pyridine or trimethylsilylethyl; and (b) attaching said sulfur atom to said gold electrode.
Claim 3
Dependent Claim
16 words
A method according to claim 1, further comprising adding additional subunits to form said conductive oligomer.
Claim 4
Dependent Claim
18 words
A method according to claim 2, further comprising adding at least a first nucleoside to said conductive oligomer.
Claim 5
Dependent Claim
20 words
A method according to claim 3, further comprising adding additional nucleosides to said first nucleoside to form a nucleic acid.
Claim 6
Dependent Claim
16 words
A method according to claim 1 wherein said protecting group is removed prior to said attachment.
Claim 7
Independent Claim
42 words
A method for attaching a conductive oligomer to a gold electrode comprising: a) providing a conductive oligomer having a covalently attached nucleic acid and a sulfur atom protected by a protecting group; and b) attaching said sulfur atom to said gold electrode.
Claim 8
Independent Claim
42 words
A method for attaching a conductive oligomer to a gold electrode comprising: a) providing a conductive oligomer having a covalently attached nucleic acid and a sulfur atom protected by a protecting group; and b) attaching said sulfur atom to said gold electrode.
Claim 9
Dependent Claim
13 words
A method according to claim 6 wherein said protecting group is ethyl pyridine.
Claim 10
Dependent Claim
12 words
A method according to claim 6 wherein said protecting group is trimethylsilylethyl.
Claim 11
Independent Claim
65 words
A method of attaching a composition to a gold electrode comprising: a) providing a first monolayer forming species comprising a covalently attached nucleic acid and a sulfur atom protected by a protecting group; b) providing a conductive oligomer comprising at least a first subunit with a sulfur atom protected by a protecting group; and c) attaching said first and second species to said gold electrode.
Claim 12
Independent Claim
65 words
A method of attaching a composition to a gold electrode comprising: a) providing a first monolayer forming species comprising a covalently attached nucleic acid and a sulfur atom protected by a protecting group; b) providing a conductive oligomer comprising at least a first subunit with a sulfur atom protected by a protecting group; and c) attaching said first and second species to said gold electrode.
Claim 13
Dependent Claim
26 words
A method according to claim 9 further comprising: a) providing a third species comprising an insulator; and b) attaching said third species to said gold electrode.
Claim 14
Dependent Claim
19 words
A method according to claim 9 or 10 wherein said protecting group is selected from ethyl pyridine or trimethylsilylethyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-07-18 | 2004-01-17 | 2004-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-07-18 | 2008-01-17 | 2008-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-07-18 | 2012-01-17 | 2012-07-18 | $7700.00 | Window Closed / Lapsed |