US6056993A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Porous protheses and methods for making the same wherein the protheses are formed by spraying water soluble and water insoluble fibers onto a rotating mandrel
Assignee: Ortech Corp
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Filing: 1998-04-17
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Granted: 2000-05-02
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Expires: 2018-04-17
Abstract
Abstract A porous, tubular synthetic prosthesis, prosthesis precursor, and methods of producing the same are provided. Specifically the method involves co-spraying both a water soluble and water insoluble fibrous component onto a mold to form the prosthesis precursor. The water soluble fibrous component may then be at least partially removed so as to provide a porous, tubular synthetic prosthesis.
Inventors
- 👤 Jacob Leidner
- 👤 Karim Amellal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:31
CPC Classifications
B; B29; B29C; B29C41/00; B29C41/02; B29C41/08; B29C41/085; A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; B29K; B29K2105/00; B29K2105/04; B29K2995/00; B29K2995/0037; B29K2995/0059; B29L; B29L2031/00; B29L2031/753; B29L2031/7532; B29L2031/7534
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
84 words
A method of making a porous, tubular, synthetic prosthesis, comprising the steps of: (a) electrostatically co-spraying ingredients comprising a water soluble fibrous component and a water insoluble fibrous component onto a mold to form a prosthesis precursor, wherein the water soluble fibrous component functions as a spacer to inhibit coalescence of the water insoluble fibrous component on the mold; and (b) removing at least a portion of the water soluble fibrous component from the precursor to form the prosthesis, said prosthesis comprising fibrous-shaped voids.
Claim 2
Independent Claim
84 words
A method of making a porous, tubular, synthetic prosthesis, comprising the steps of: (a) electrostatically co-spraying ingredients comprising a water soluble fibrous component and a water insoluble fibrous component onto a mold to form a prosthesis precursor, wherein the water soluble fibrous component functions as a spacer to inhibit coalescence of the water insoluble fibrous component on the mold; and (b) removing at least a portion of the water soluble fibrous component from the precursor to form the prosthesis, said prosthesis comprising fibrous-shaped voids.
Claim 3
Independent Claim
45 words
A method of making a tubular prosthesis precursor, comprising the step of co-spraying a water insoluble, fibrous component and a water soluble fibrous component onto a mold to form the tubular prosthesis precursor comprising a water soluble fibrous component and a water insoluble fibrous component.
Claim 4
Independent Claim
45 words
A method of making a tubular prosthesis precursor, comprising the step of co-spraying a water insoluble, fibrous component and a water soluble fibrous component onto a mold to form the tubular prosthesis precursor comprising a water soluble fibrous component and a water insoluble fibrous component.
Claim 5
Dependent Claim
12 words
The method of claim 1, wherein the mold is a rotating mandrel.
Claim 6
Dependent Claim
24 words
The method of claim 1, wherein step (b) comprises eluting the water soluble fibrous component by washing the tubular prosthesis precursor with an eluent.
Claim 7
Dependent Claim
10 words
The method of claim 4, wherein the eluent is water.
Claim 8
Dependent Claim
59 words
The method of claim 1, wherein the prosthesis precursor is tubular and wherein step (b) comprises removing a sufficient amount of the water soluble, fibrous component from the precursor such that the prosthesis has an inner wall surface with a sufficient amount of porosity to promote the ingrowth of tissue when the prosthesis is therapeutically implanted in a host.
Claim 9
Dependent Claim
20 words
The method of claim 1, wherein the prosthesis has a porosity in the range from about 5% to about 95%.
Claim 10
Dependent Claim
18 words
The method of claim 7, wherein the prosthesis has a porosity of from about 60% to about 95%.
Claim 11
Dependent Claim
18 words
The method of claim 8, wherein the prosthesis has a porosity of from about 70% to about 80%.
Claim 12
Dependent Claim
69 words
The method of claim 1, wherein the prosthesis mold is a rotating mandrel, and said co-spraying step comprises electrostatically co-spraying the water insoluble and water soluble fibrous components onto the rotating mandrel from first and second orifices, respectively, and wherein the first and second orifices are caused to translate axially back and forth relative to the mandrel such that the fibrous components coat the mandrel to form said precursor.
Claim 13
Dependent Claim
58 words
The method of claim 10, wherein the co-spraying step comprises the steps of: (i) extruding a first composition comprising a water insoluble silicone resin through the first orifice to form the water insoluble fibrous component; and (ii) extruding a second composition comprising a water soluble polyethylene glycol through the second orifice to form the water soluble fiber component.
Claim 14
Dependent Claim
19 words
The method of claim 11, wherein the polyethylene glycol has a weight average molecular weight of at least 1000.
Claim 15
Dependent Claim
24 words
The method of claim 12, wherein the polyethylene glycol has a weight average molecular weight in the range from about 1000 to about 15,000.
Claim 16
Dependent Claim
51 words
The method of claim 11, wherein the first composition further comprises a solvent in which the silicone resin is substantially completely soluble, said solvent comprising first and second solvent components, wherein the first solvent component has a boiling point at least 10° C. greater than that of the second solvent component.
Claim 17
Dependent Claim
26 words
The method of claim 14, wherein the first solvent component has a boiling point at least 25° C. greater than that of the second solvent component.
Claim 18
Dependent Claim
30 words
The method of claim 14, wherein the weight ratio of the second solvent component to the first solvent component is in the range of from about 2:1 to about 10:1.
Claim 19
Dependent Claim
27 words
The method of claim 14, wherein the solvent comprises a halogenated alkane solvent selected from a trihaloethane, a dihaloethane, a trihalomethane, a dihalomethane, or combinations of these.
Claim 20
Dependent Claim
25 words
The method of claim 17, wherein the solvent comprises 1 to 20 parts by weight dichloromethane and 1 to 20 parts by weight of trichloroethane.
Claim 21
Dependent Claim
32 words
The method of claim 1, wherein the weight ratio of the water insoluble fibrous component to the water soluble fibrous component is in the range of from about 1:10 to about 5:1.
Claim 22
Dependent Claim
32 words
The method of claim 19, wherein the weight ratio of the water insoluble fibrous component to the water soluble fibrous component is in the range of from about 1:3 to about 1:2.
Claim 23
Dependent Claim
94 words
The method of claim 1, wherein the co-spraying step comprises co-spraying both the water insoluble and water soluble fibrous components onto the mold to build up an inner portion of the tubular prosthesis precursor, and wherein the method further comprises the steps of: (i) ceasing to spray the water soluble fibrous component onto the mold when said inner portion is formed, and (ii) after ceasing to spray the water soluble fibrous component onto the mold, continuing to spray the water insoluble fibrous component onto the mold until said tubular prosthesis precursor body is formed.
Claim 24
Dependent Claim
28 words
The method of claim 1, further comprising the step of, prior to co-spraying said fibrous components onto the mold, coating the mold with a coating comprising polyethylene glycol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-05-02 | 2003-11-01 | 2004-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-05-02 | 2007-11-01 | 2008-05-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-05-02 | 2011-11-01 | 2012-05-02 | $7700.00 | Window Closed / Lapsed |