US6048332A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dimpled porous infusion balloon
Assignee: Medtronic Vascular Connaught
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Filing: 1998-10-09
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Granted: 2000-04-11
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Expires: 2018-10-09
Abstract
Abstract The systems and methods described herein include drug delivery catheters that have dimpled porous balloons mounted onto the distal end of the catheter. In one embodiment, the balloons are adapted for delivering therapeutic agents to the tissue wall of a body lumen, and to this end include a plurality of dimples formed in the exterior surface of the balloon, with each dimple having at least one aperture through which a fluid delivered into the interior of the balloon can extravasate. It is understood that the balloons described herein provide, inter alia, increased coverage of the tissue wall to which the agent is being delivered and less traumatic contact between the agent being delivered and the tissue wall.
Inventors
- 👤 Niall Duffy
- 👤 Micheal O'Loughlin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:08
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/1002; A61M2025/1043; A61M2025/105; A61M2025/1086
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
126 words
Apparatus for applying a fluid vehicle carrying a therapeutic agent to an interior surface of a body lumen, comprising: a catheter having a distal portion, a proximal portion and a lumen therethrough; and a balloon mounted on the distal portion of the catheter having an interior in fluid communication with the lumen of the catheter and having a wall capable of being expanded within the body lumen to contact the interior surface of the body lumen, said wall being penetrated by at least one aperture situated within a concavity in the wall of the balloon; whereby the therapeutic agent can be delivered from the interior of the balloon through the aperture in the wall of the balloon to contact the interior surface of the body lumen.
Claim 2
Dependent Claim
126 words
Apparatus for applying a fluid vehicle carrying a therapeutic agent to an interior surface of a body lumen, comprising: a catheter having a distal portion, a proximal portion and a lumen therethrough; and a balloon mounted on the distal portion of the catheter having an interior in fluid communication with the lumen of the catheter and having a wall capable of being expanded within the body lumen to contact the interior surface of the body lumen, said wall being penetrated by at least one aperture situated within a concavity in the wall of the balloon; whereby the therapeutic agent can be delivered from the interior of the balloon through the aperture in the wall of the balloon to contact the interior surface of the body lumen.
Claim 3
Dependent Claim
40 words
Apparatus according to claim 1 wherein the wall of the balloon bears a plurality of concavities, each of said concavities containing within it at least one aperture adapted for permitting the egress of the fluid vehicle carrying the therapeutic agent.
Claim 4
Dependent Claim
43 words
Apparatus according to claim 1 wherein the concavity in the wall of the balloon spaces the aperture away from the tissue wall for decreasing the velocity at which the fluid vehicle carrying the therapeutic agent contacts the interior surface of the body lumen.
Claim 5
Dependent Claim
22 words
Apparatus according to claim 1 wherein the concavity in the wall of the balloon permits accumulation of the fluid vehicle under pressure.
Claim 6
Dependent Claim
10 words
Apparatus according to claim wherein the concavity is substantially hemispherical.
Claim 7
Dependent Claim
19 words
Apparatus according to claim 2 wherein each concavity is penetrated substantially at its base by at least one aperture.
Claim 8
Dependent Claim
21 words
Apparatus according to claim 1 wherein the catheter and the balloon are dimensionally adapted to be disposed within a blood vessel.
Claim 9
Dependent Claim
154 words
Apparatus for applying a fluid vehicle carrying a therapeutic agent to an interior surface of a body lumen, comprising: a catheter having a distal portion and a proximal portion and a lumen therethrough; and a first balloon mounted on said distal portion of the catheter having an interior in fluid communication with the lumen of the catheter and having a wall capable of being expanded within the body lumen to contact the interior surface of the body lumen, said wall being indented by a plurality of concavities, each of said concavities being penetrated by at least one aperture permitting egress of the fluid vehicle carrying the therapeutic agent; wherein the concavities in the wall of the balloon distance the apertures in the wall from the interior surface of the body lumen and accumulate the therapeutic agent within the concavities, thereby bringing the therapeutic agent into contact with the interior surface of the body lumen.
Claim 10
Dependent Claim
154 words
Apparatus for applying a fluid vehicle carrying a therapeutic agent to an interior surface of a body lumen, comprising: a catheter having a distal portion and a proximal portion and a lumen therethrough; and a first balloon mounted on said distal portion of the catheter having an interior in fluid communication with the lumen of the catheter and having a wall capable of being expanded within the body lumen to contact the interior surface of the body lumen, said wall being indented by a plurality of concavities, each of said concavities being penetrated by at least one aperture permitting egress of the fluid vehicle carrying the therapeutic agent; wherein the concavities in the wall of the balloon distance the apertures in the wall from the interior surface of the body lumen and accumulate the therapeutic agent within the concavities, thereby bringing the therapeutic agent into contact with the interior surface of the body lumen.
Claim 11
Dependent Claim
11 words
Apparatus according to claim 8, wherein the concavities are substantially hemispherical.
Claim 12
Dependent Claim
19 words
Apparatus according to claim 8, wherein at least one aperture is situated substantially at the base of each concavity.
Claim 13
Dependent Claim
21 words
Apparatus according to claim 8, wherein the catheter and the balloon are dimensionally adapted to be disposed within a blood vessel.
Claim 14
Dependent Claim
20 words
Apparatus according to claim 8, wherein at least one additional balloon is mounted on the distal portion of the catheter.
Claim 15
Dependent Claim
21 words
Apparatus according to claim 12 wherein the first balloon is disposed exterior to and coaxial with at least one additional balloon.
Claim 16
Dependent Claim
26 words
Apparatus according to claim 12, wherein at least one additional balloon is a dilating balloon adapted for the dilatation of a stenosis of a body lumen.
Claim 17
Independent Claim
193 words
A method for applying at therapeutic agent to an interior surface of a body lumen, comprising: providing a catheter having a distal portion and a proximal portion and a lumen therethrough, a balloon disposed on the distal portion of the catheter with an interior in fluid communication with the lumen of the catheter and with a wall having a plurality of apertures and a plurality of concavities each bearing at least one aperture, a means for inflating the balloon and a means for directing a fluid vehicle carrying the therapeutic agent through the inner lumen of the catheter to the interior of the balloon; inserting the catheter into a patient; positioning the balloon within the body lumen; inflating the balloon in the body lumen to attain contact with the inner surface of the body lumen; maintaining a level of fluid pressure in the balloon so that the fluid vehicle carrying the therapeutic agent extravasates through the perforations in the wall at a flow rate selected to deliver a desired quantity of the therapeutic agent to the inner surface of the body lumen; deflating the balloon; and removing the catheter from the body lumen.
Claim 18
Independent Claim
193 words
A method for applying at therapeutic agent to an interior surface of a body lumen, comprising: providing a catheter having a distal portion and a proximal portion and a lumen therethrough, a balloon disposed on the distal portion of the catheter with an interior in fluid communication with the lumen of the catheter and with a wall having a plurality of apertures and a plurality of concavities each bearing at least one aperture, a means for inflating the balloon and a means for directing a fluid vehicle carrying the therapeutic agent through the inner lumen of the catheter to the interior of the balloon; inserting the catheter into a patient; positioning the balloon within the body lumen; inflating the balloon in the body lumen to attain contact with the inner surface of the body lumen; maintaining a level of fluid pressure in the balloon so that the fluid vehicle carrying the therapeutic agent extravasates through the perforations in the wall at a flow rate selected to deliver a desired quantity of the therapeutic agent to the inner surface of the body lumen; deflating the balloon; and removing the catheter from the body lumen.
Claim 19
Dependent Claim
15 words
A method according to claim 15 including dilating a stenotic region of the body lumen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-04-11 | 2003-10-11 | 2004-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-04-11 | 2007-10-11 | 2008-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-04-11 | 2011-10-11 | 2012-04-11 | $7700.00 | Window Closed / Lapsed |