US5997575A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perforated submucosal tissue graft constructs
Assignee: Methodist Hospital
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Filing: 1997-09-18
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Granted: 1999-12-07
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Expires: 2017-09-18
Abstract
Abstract A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.
Inventors
- 👤 Bryan Whitson
- 👤 Boyle Cheng
- 👤 Stephen F. Badylak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 20:44
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61F; A61F2/00; A61F2/02; A61L27/3604; A61L27/3629; A61F2240/00; A61F2240/001
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
105 words
A unitary multi-laminate tissue graft construct comprising multiple strips of intestinal submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, wherein at least a portion of each strip of intestinal submucosa tissue overlaps and is bonded to another strip of submucosa tissue of the multi-laminate submucosa graft construct, said graft construct comprising first and second surfaces wherein the surfaces are perforated with at least 2 perforations per cm 2 , said perforations having a diameter of about 0.6 to 2 mm and providing fluid communication between the first and second planar surfaces.
Claim 2
Dependent Claim
105 words
A unitary multi-laminate tissue graft construct comprising multiple strips of intestinal submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, wherein at least a portion of each strip of intestinal submucosa tissue overlaps and is bonded to another strip of submucosa tissue of the multi-laminate submucosa graft construct, said graft construct comprising first and second surfaces wherein the surfaces are perforated with at least 2 perforations per cm 2 , said perforations having a diameter of about 0.6 to 2 mm and providing fluid communication between the first and second planar surfaces.
Claim 3
Dependent Claim
19 words
The graft construct of claim 1, wherein the perforations are uniformly distributed over the surfaces of the graft construct.
Claim 4
Dependent Claim
14 words
The graft construct of claim 1, wherein the perforations are of substantially uniform size.
Claim 5
Dependent Claim
21 words
The graft construct of claim 1, wherein the overlapped portions are fused together by compressing the overlapped portions under dehydrating conditions.
Claim 6
Dependent Claim
13 words
The graft construct of claim 1, wherein the overlapped portions are sutured together.
Claim 7
Dependent Claim
85 words
An improved unitary multi-laminate submucosa graft construct, comprising multiple strips of intestinal submucosa tissue delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, wherein at least a portion of each strip of intestinal submucosa tissue overlaps and is bonded to another strip of submucosa tissue of the multi-laminate submucosa graft construct; said graft construct provided with a sufficient number of perforations effective to reduce fluid accumulation between the layers of said graft construct.
Claim 8
Dependent Claim
85 words
An improved unitary multi-laminate submucosa graft construct, comprising multiple strips of intestinal submucosa tissue delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, wherein at least a portion of each strip of intestinal submucosa tissue overlaps and is bonded to another strip of submucosa tissue of the multi-laminate submucosa graft construct; said graft construct provided with a sufficient number of perforations effective to reduce fluid accumulation between the layers of said graft construct.
Claim 9
Dependent Claim
19 words
The graft construct of claim 6, wherein the perforations are uniformly distributed over the surfaces of the graft construct.
Claim 10
Dependent Claim
14 words
The graft construct of claim 6, wherein the perforations are of substantially uniform size.
Claim 11
Dependent Claim
21 words
The graft construct of claim 6, wherein the overlapped portions are fused together by compressing the overlapped portions under dehydrating conditions.
Claim 12
Dependent Claim
13 words
The graft construct of claim 6, wherein the overlapped portions are sutured together.
Claim 13
Dependent Claim
99 words
An improved unitary multi-laminate submucosa graft construct, comprising multiple strips of intestinal submucosa tissue delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, wherein at least a portion of each strip of intestinal submucosa tissue overlaps and is fused to another strip of submucosa tissue of the multi-laminate submucosa graft construct; said graft construct provided with a sufficient number of perforations effective to reduce fluid accumulation between the layers of said graft construct graft construct, said perforations having a diameter of about 0.5 to about 3 mm.
Claim 14
Dependent Claim
99 words
An improved unitary multi-laminate submucosa graft construct, comprising multiple strips of intestinal submucosa tissue delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, wherein at least a portion of each strip of intestinal submucosa tissue overlaps and is fused to another strip of submucosa tissue of the multi-laminate submucosa graft construct; said graft construct provided with a sufficient number of perforations effective to reduce fluid accumulation between the layers of said graft construct graft construct, said perforations having a diameter of about 0.5 to about 3 mm.
Claim 15
Dependent Claim
20 words
The graft construct of claim 11 wherein graft construct is provided with at least 2 perforations per cm 2 .
References Cited (Backward Citations)
US2127903A
Cited
US3562820A
Cited
US4729766A
Cited
US4932973A
Cited
US5002572A
Cited
US5350583A
Cited
US4902508A
Cited
US4956178A
Cited
US5219361A
Cited
US5306304A
Cited
US5455100A
Cited
US5281422A
Cited
US5372821A
Cited
US5496372A
Cited
US5275826A
Cited
US5352463A
Cited
WO1995006439A1
Cited
US5645860A
Cited
US5711969A
Cited
US5733337A
Cited
US5755791A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-12-06 | 2003-06-07 | 2003-12-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-12-06 | 2007-06-07 | 2007-12-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-12-06 | 2011-06-07 | 2011-12-07 | $7700.00 | Window Closed / Lapsed |