Patent US5995860A successfully refreshed from Google Patents.
US5995860A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable sensor and system for measurement and control of blood constituent levels
Assignee: Thomas Jefferson University
•
Filing: 1995-07-06
•
Granted: 1999-11-30
•
Expires: 2015-07-06
Abstract
Abstract An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue has at least one source of radiation from infrared through visible light, arranged to direct the radiation at the tissue where it is affected by interaction with the tissue, and a plurality of detectors. Each detector has associated with it a filter transparent to a discrete narrow band of radiation, and each detector provides an output signal representative of detected radiation in that narrow band. The detectors are located with respect to the tissue to receive radiation affected by the tissue. The invention also encompasses a device for measuring and controlling the level of a blood constituent, such as glucose, in a mammal, and includes an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has passed through the tissue and generating an output signal representative of the sensed infrared radiation. The device includes a processor module responsive to the output signal from the infrared source and sensor module which performs spectral analysis of the output signal and derives from that analysis a control signal representative of the level of the blood constituent. The device further includes an insulin pump for dispensing doses of insulin in response to the control signal for blood glucose regulation.
Inventors
- 👤 Xiaoguang Sun
- 👤 Jeffrey I. Joseph
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 19:15
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/14244; A61M5/14276; A61B; A61B5/00; A61B5/0002; A61B5/0031; A61B5/145; A61B5/14532; A61B5/1455; A61B5/1459; A61B5/41; A61B5/412; A61B5/68; A61B5/6846; A61B5/6867; A61B5/6876; A61B5/6879; A61B5/6884; A61B5/02; A61B5/026; A61B5/029; A61M2205/00; A61M2205/35; A61M2205/3507; A61M5/168; A61M5/172; A61M5/1723
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
105 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue, comprising: at least one implantable source of radiation from infrared through visible light, arranged to direct said radiation at said tissue, said radiation being affected directly by interaction with said tissue, and a plurality of implantable detectors, each having associated with it a filter transparent to a discrete narrow band of radiation, each detector providing an output signal representative of detected radiation in said narrow band, the detectors being located with respect to the tissue to receive said radiation affected directly by interaction with said tissue.
Claim 2
Dependent Claim
105 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue, comprising: at least one implantable source of radiation from infrared through visible light, arranged to direct said radiation at said tissue, said radiation being affected directly by interaction with said tissue, and a plurality of implantable detectors, each having associated with it a filter transparent to a discrete narrow band of radiation, each detector providing an output signal representative of detected radiation in said narrow band, the detectors being located with respect to the tissue to receive said radiation affected directly by interaction with said tissue.
Claim 3
Dependent Claim
62 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, further comprising a channel having an internal circumference around which are arranged said source and said detectors, said channel being dimensioned to receive a blood vessel therein and to locate said vessel in proximity to said source and detectors.
Claim 4
Dependent Claim
80 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, further comprising a first half and a second half, one half supporting said at least one source and the other half supporting at least one of said plurality of detectors, said halves being spaced apart and defining a gap therebetween for receiving said vascular tissue therein and locating said tissue in proximity to said source and detectors.
Claim 5
Dependent Claim
48 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 3, further comprising said halves being separate from one another and movable reciprocally toward and away from each other for varying the size of said gap.
Claim 6
Dependent Claim
43 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 4, further comprising an adjustable fastener for adjustably fastening said halves together and for adjustably varying the size of said gap.
Claim 7
Dependent Claim
49 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 5, wherein the adjustable fastener comprises a rotatable screw in one of said halves and a threaded bore receiving said screw in the other of said halves.
Claim 8
Dependent Claim
70 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein said at least one source and said plurality of detectors are arranged in a linear array, at least one of said plurality of detectors being located opposite said source and spaced therefrom by a distance sufficient to receive said tissue between said source and said detector.
Claim 9
Dependent Claim
70 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein said at least one source and said plurality of detectors are arranged in a planar array, at least one of said plurality of detectors being located opposite said source and spaced therefrom by a distance sufficient to receive said tissue between said source and said detector.
Claim 10
Dependent Claim
54 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one detector of said plurality of detectors is located opposite said source and at least one detector of said plurality of detectors is located next to said source.
Claim 11
Dependent Claim
41 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation scattered by said tissue.
Claim 12
Dependent Claim
41 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation transmitted through said tissue.
Claim 13
Dependent Claim
41 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation reflected by said tissue.
Claim 14
Dependent Claim
59 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation scattered by said tissue and at least one of said plurality of detectors is located to detect radiation transmitted through said tissue.
Claim 15
Dependent Claim
76 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation scattered by said tissue, at least one of said plurality of detectors is located to detect radiation transmitted by said tissue, and at least one of said plurality of detectors is arranged to detect radiation reflected by said tissue.
Claim 16
Dependent Claim
60 words
An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one optical fiber is used in conjunction with at least a selected one of said source and detectors for conveying said radiation between said selected one of said source and detectors and said tissue.
Claim 17
Independent Claim
111 words
A device for measuring and controlling the level of blood glucose in a mammal, comprising: an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has interacted directly with the tissue and generating an output signal representative of the direct interaction of infrared radiation with the tissue, a processor module responsive to the output signal from the infrared source and sensor module for performing spectral analysis of the output signal and deriving therefrom a control signal related to the level of said blood glucose, and an insulin pump for dispensing doses of insulin in response to the control signal.
Claim 18
Independent Claim
111 words
A device for measuring and controlling the level of blood glucose in a mammal, comprising: an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has interacted directly with the tissue and generating an output signal representative of the direct interaction of infrared radiation with the tissue, a processor module responsive to the output signal from the infrared source and sensor module for performing spectral analysis of the output signal and deriving therefrom a control signal related to the level of said blood glucose, and an insulin pump for dispensing doses of insulin in response to the control signal.
Claim 19
Dependent Claim
30 words
A device for measuring and controlling the level of blood glucose in a mammal according to claim 16, wherein the insulin pump is external to the body of the mammal.
Claim 20
Dependent Claim
30 words
A device for measuring and controlling the level of blood glucose in a mammal according to claim 16, wherein the insulin pump is implantable within the body of the mammal.
Claim 21
Dependent Claim
106 words
A device for measuring and controlling the level of blood glucose in a mammal according to claim 16, wherein the source and sensor module comprises at least one source of radiation from infrared through visible light, arranged to direct said radiation at said tissue, said radiation being affected by interaction with said tissue, and a plurality of detectors, each having associated with it a filter transparent to a discrete narrow band of radiation, each detector providing an output signal representative of detected radiation in said narrow band, the detectors being located with respect to the tissue to receive radiation from said source affected by said tissue.
Claim 22
Independent Claim
111 words
A device for measuring and controlling the level of a blood constituent in a mammal, comprising an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has interacted directly with the tissue and generating an output signal representative of the direct interaction of infrared radiation with the tissue; a processor module responsive to the output signal from the infrared source and sensor module for performing spectral analysis of the output signal and deriving therefrom a control signal related to the level of said blood constituent; and a pump for dispensing doses of medication in response to the control signal.
Claim 23
Independent Claim
111 words
A device for measuring and controlling the level of a blood constituent in a mammal, comprising an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has interacted directly with the tissue and generating an output signal representative of the direct interaction of infrared radiation with the tissue; a processor module responsive to the output signal from the infrared source and sensor module for performing spectral analysis of the output signal and deriving therefrom a control signal related to the level of said blood constituent; and a pump for dispensing doses of medication in response to the control signal.
References Cited (Backward Citations)
US3837339A
Cited
US4013074A
Cited
US4073292A
Cited
US4398908A
Cited
US4435173A
Cited
US4621643A
Cited
US4679562A
Cited
US4633878A
Cited
US4538616A
Cited
US4704029A
Cited
US4830488A
Cited
US4807629A
Cited
US4865038A
Cited
US4825879A
Cited
US4890621A
Cited
US4822336A
Cited
US5305745A
Cited
US5127406A
Cited
US5204532A
Cited
US4979509A
Cited
US5190041A
Cited
US5368028A
Cited
US5101814A
Cited
US5054487A
Cited
US5179951A
Cited
JPH0415046A
Cited
US5361759A
Cited
WO1992011801A1
Cited
US5353792A
Cited
US5598841A
Cited
US5474552A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-11-29 | 2003-05-31 | 2003-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-11-29 | 2007-05-31 | 2007-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-11-29 | 2011-05-31 | 2011-11-30 | $7700.00 | Window Closed / Lapsed |