US5928671A
Expired / Lapsed
US
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Method and composition for inhibiting bacteria
Assignee: NYU Langone Hospital - Long Island
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Filing: 1997-06-26
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Granted: 1999-07-27
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Expires: 2017-06-26
Abstract
Abstract A composition comprising a trivalent bismuth salt, particularly bismuth nitrate, and dimercaprol is described. Methods for using the composition as a bacteriocidal and bacteriostatic agent and as a disinfectant and preservative are also provided.
Inventors
- 👤 Philip Domenico
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 22:37
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/24; A61K33/245; A61K31/00; A61K31/095
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
40 words
A composition, comprising: a trivalent bismuth salt; and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol, wherein the molar ratio of said trivalent bismuth salt to said compound is approximately 1:2 to approximately 3:1.
Claim 2
Dependent Claim
40 words
A composition, comprising: a trivalent bismuth salt; and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol, wherein the molar ratio of said trivalent bismuth salt to said compound is approximately 1:2 to approximately 3:1.
Claim 3
Dependent Claim
27 words
A composition, as recited in claim 1, wherein said trivalent bismuth salt is selected from the group consisting of bismuth nitrate, colloidal bismuth subcitrate and bismuth subsalicylate.
Claim 4
Dependent Claim
17 words
A composition, as recited in claim 1, wherein said molar ratio is approximately 1:1 to approximately 3:1.
Claim 5
Dependent Claim
17 words
A composition, as recited in claim 1, wherein said molar ratio is approximately 2:1 to approximately 3:1.
Claim 6
Dependent Claim
15 words
A composition, as recited in claim 1, further comprising a pharmaceutically acceptable diluent or carrier.
Claim 7
Dependent Claim
39 words
A composition, comprising: a trivalent bismuth salt; and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol, wherein said trivalent bismuth salt and said compound are present in the molar ratio of approximately 3:1.
Claim 8
Dependent Claim
39 words
A composition, comprising: a trivalent bismuth salt; and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol, wherein said trivalent bismuth salt and said compound are present in the molar ratio of approximately 3:1.
Claim 9
Independent Claim
46 words
A method of preventing or inhibiting bacterial infection, comprising the step of: administering a therapeutically effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol to a patient, in need thereof.
Claim 10
Independent Claim
46 words
A method of preventing or inhibiting bacterial infection, comprising the step of: administering a therapeutically effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol to a patient, in need thereof.
Claim 11
Dependent Claim
27 words
A method, as recited in claim 7, wherein said trivalent bismuth salt is selected from the group consisting of bismuth nitrate, colloidal bismuth subcitrate and bismuth subsalicylate.
Claim 12
Dependent Claim
30 words
A method, as recited in claim 8, wherein the molar ratio of said trivalent bismuth salt to said compound is not less than approximately 1:2 nor more than approximately 3:1.
Claim 13
Dependent Claim
17 words
A method, as recited in claim 9, wherein said molar ratio is approximately 1:1 to approximately 3:1.
Claim 14
Dependent Claim
17 words
A method, as recited in claim 9, wherein said molar ratio is approximately 2:1 to approximately 3:1.
Claim 15
Independent Claim
47 words
A method of eradicating bacteria, comprising the step of: applying to an area on which it is desired to eradicate bacteria an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.
Claim 16
Independent Claim
47 words
A method of eradicating bacteria, comprising the step of: applying to an area on which it is desired to eradicate bacteria an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.
Claim 17
Dependent Claim
27 words
A method, as recited in claim 12, wherein said trivalent bismuth salt is selected from the group consisting of bismuth nitrate, colloidal bismuth subcitrate and bismuth subsalicylate.
Claim 18
Dependent Claim
30 words
A method, as recited in claim 13, wherein the molar ratio of said trivalent bismuth salt to said compound is not less than approximately 1:2 nor more than approximately 3:1.
Claim 19
Dependent Claim
17 words
A method, as recited in claim 14, wherein said molar ratio is approximately 1:1 to approximately 3:1.
Claim 20
Dependent Claim
17 words
A method, as recited in claim 14, wherein said molar ratio is approximately 2:1 to approximately 3:1.
Claim 21
Independent Claim
57 words
A method of preventing the formation or growth of biofilms, comprising the step of: applying to an area on which it is desired to prevent the formation or growth of biofilms an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.
Claim 22
Independent Claim
57 words
A method of preventing the formation or growth of biofilms, comprising the step of: applying to an area on which it is desired to prevent the formation or growth of biofilms an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.
Claim 23
Independent Claim
47 words
A method of preventing spoilage, comprising the step of: applying to a product on which it is desired to prevent spoilage an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.
Claim 24
Independent Claim
47 words
A method of preventing spoilage, comprising the step of: applying to a product on which it is desired to prevent spoilage an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-07-26 | 2003-01-25 | 2003-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-07-26 | 2007-01-25 | 2007-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-07-26 | 2011-01-25 | 2011-07-27 | $7700.00 | Window Closed / Lapsed |