US5922304A
Expired / Lapsed
US
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Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
Assignee: Cerevast Medical Inc
•
Filing: 1995-03-09
•
Granted: 1999-07-13
•
Expires: 2015-03-09
Abstract
Abstract Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K41/00; A61K41/0028; A61K41/0052; A61K47/00; A61K47/50; A61K47/69; A61K47/6905; A61K47/6911; A61K47/6921; A61K47/6925; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; A61K49/1815; A61K49/1818; A61K49/1821; A61K49/22; A61K49/222; A61K49/223; A61K49/227; A61K9/1277; A61K9/1278; A61K9/48; A61K9/50; A61K9/5005; A61K9/5015; G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A61M; A61M5/00; A61M5/178; A61M5/31; A61M5/3145
Claims Analysis
Total Claims: 45
Claim 1
Independent Claim
84 words
A method of providing an image of an internal region of a patient comprising (i) administering to the patient a gaseous precursor filled microsphere, wherein said microsphere contains substantially no sulfide linkages and consists essentially of one or more lipids, one or more lipids bearing polymers, or combinations thereof, (ii) allowing the gaseous precursor to undergo a phase transition from a liquid to a gas in the patient, and (iii) scanning the patient using magnetic resonance imaging to obtain visible images of said region.
Claim 2
Independent Claim
84 words
A method of providing an image of an internal region of a patient comprising (i) administering to the patient a gaseous precursor filled microsphere, wherein said microsphere contains substantially no sulfide linkages and consists essentially of one or more lipids, one or more lipids bearing polymers, or combinations thereof, (ii) allowing the gaseous precursor to undergo a phase transition from a liquid to a gas in the patient, and (iii) scanning the patient using magnetic resonance imaging to obtain visible images of said region.
Claim 3
Independent Claim
92 words
A method for diagnosing the presence of a diseased tissue or region in a patient comprising (i) administering to the patient a gaseous precursor filled microsphere, wherein said microsphere contains substantially no sulfide linkages and consists essentially of one or more lipids, one or more lipids bearing polymers, or combinations thereof, (ii) allowing the gaseous precursor to undergo a phase transition from a liquid to a gas in the patient, and (iii) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue or region in the patient.
Claim 4
Independent Claim
92 words
A method for diagnosing the presence of a diseased tissue or region in a patient comprising (i) administering to the patient a gaseous precursor filled microsphere, wherein said microsphere contains substantially no sulfide linkages and consists essentially of one or more lipids, one or more lipids bearing polymers, or combinations thereof, (ii) allowing the gaseous precursor to undergo a phase transition from a liquid to a gas in the patient, and (iii) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue or region in the patient.
Claim 5
Dependent Claim
14 words
A method according to claim 1 or 2 wherein the region is the vasculature.
Claim 6
Dependent Claim
15 words
A method according to claim 1 or 2 wherein the region is the cardiovascular region.
Claim 7
Dependent Claim
15 words
A method according to claim 1 or 2 wherein the region is the gastrointestinal region.
Claim 8
Dependent Claim
18 words
A method according to claim 1 or 2 wherein the scanning is of the vasculature of the patient.
Claim 9
Dependent Claim
19 words
A method according to claim 1 or 2 wherein the scanning is of the cardiovascular region of the patient.
Claim 10
Dependent Claim
19 words
A method according to claim 1 or 2 wherein the scanning is of the gastrointestinal region of the patient.
Claim 11
Dependent Claim
35 words
A method according to claim 1 or 2 wherein the scanning is of a region of the patient selected from the following: intranasal tract; auditory canal; intraocular region; intraperitoneal region; kidneys; urethra; and genitourinary tract.
Claim 12
Dependent Claim
11 words
A method of claim 1 wherein said lipid is a phospholipid.
Claim 13
Dependent Claim
11 words
A method of claim 2 wherein said lipid is a phospholipid.
Claim 14
Dependent Claim
11 words
A method of claim 1 wherein said microsphere comprises a monolayer.
Claim 15
Dependent Claim
11 words
A method of claim 12 wherein said monolayer comprises a phospholipid.
Claim 16
Dependent Claim
11 words
A method of claim 2 wherein said microsphere comprises a monolayer.
Claim 17
Dependent Claim
11 words
A method of claim 14 wherein said monolayer comprises a phospholipid.
Claim 18
Dependent Claim
12 words
A method of claim 1 wherein said gaseous precursor is a perfluorocarbon.
Claim 19
Dependent Claim
29 words
A method of claim 11 wherein said gaseous precursor is selected from the group consisting of sulfur hexafluoride, perfluoromethane, perfluoroethane, perfluoropropane, perfluorocyclopropane, perfluorobutane, perfluorocyclobutane, perfluoropentane, perfluorocyclopentane, perfluorohexane, and perfluoroheptane.
Claim 20
Dependent Claim
11 words
A method of claim 17 wherein said gaseous precursor is perfluorohexane.
Claim 21
Dependent Claim
11 words
A method of claim 17 wherein said gaseous precursor is perfluoropropane.
Claim 22
Dependent Claim
21 words
A method of claim 17 wherein said gaseous precursor is selected from the group consisting of perfluoropentane, perfluorocyclopentane, perfluorohexane, and perfluoroheptane.
Claim 23
Dependent Claim
11 words
A method of claim 20 wherein said gaseous precursor is perfluoropentane.
Claim 24
Dependent Claim
14 words
A method of claim 1 wherein said microsphere is rehydrated from a lyophilized microsphere.
Claim 25
Dependent Claim
20 words
A method of claim 1 wherein said lipid microsphere comprises at least 70 mole percent of at least one lipid.
Claim 26
Dependent Claim
48 words
A method of claim 1 wherein said lipid microsphere comprises at least two lipids wherein said first lipid contains substantially no linkages to a polymer and comprises at least 70 mole percent of the total moles of the microsphere, and wherein said second lipid bears a hydrophilic polymer.
Claim 27
Dependent Claim
38 words
A method of claim 24 wherein said first lipid comprises: (i) a neutral lipid, and (ii) a negatively charged lipid, wherein the amount of said negatively charged lipid is greater than 1 mole percent of total lipids present.
Claim 28
Dependent Claim
13 words
A method of claim 25 wherein said negatively charged lipid is phosphatidic acid.
Claim 29
Dependent Claim
28 words
A method of claim 24 wherein the hydrophilic polymer of said second lipid is selected from the group consisting of polyethyleneglycol, polypropyleneglycol, polyvinylalcohol, and polyvinylpyrrolidone and copolymers thereof.
Claim 30
Dependent Claim
28 words
A method of claim 24 wherein the lipids comprise about 77.5 mole percent dipalmitoyl-phosphatidylcholine, about 12.5 mole percent of dipalmitoyl-phosphatidic-acid, and about 10 mole percent of dipalmitoylphosphatidylethanolamine-polyethyleneglycol 5000.
Claim 31
Dependent Claim
29 words
A method of claim 24 wherein the lipids comprise about 82 mole percent dipalmitoylphosphatidyl-choline, about 10 mole percent of dipalmitoylphosphatidic acid, and about 8 mole percent of dipalmitoylphosphatidyl-ethanolamine-polyethyleneglycol 5000.
Claim 32
Dependent Claim
12 words
A method of claim 2 wherein said gaseous precursor is a perfluorocarbon.
Claim 33
Dependent Claim
29 words
A method of claim 2 wherein said gaseous precursor is selected from the group consisting of sulfur hexafluoride, perfluoromethane, perfluoroethane, perfluoropropane, perfluorocyclopropane, perfluorobutane, perfluorocyclobutane, perfluoropentane, perfluorocyclopentane, perfluorohexane, and perfluoroheptane.
Claim 34
Dependent Claim
11 words
A method of claim 31 wherein said gaseous precursor is perfluorohexane.
Claim 35
Dependent Claim
11 words
A method of claim 31 wherein said gaseous precursor is perfluoropropane.
Claim 36
Dependent Claim
21 words
A method of claim 31 wherein said gaseous precursor is selected from the group consisting of perfluoropentane, perfluorocyclopentane, perfluorohexane, and perfluoroheptane.
Claim 37
Dependent Claim
11 words
A method of claim 31 wherein said gaseous precursor is perfluoropentane.
Claim 38
Dependent Claim
14 words
A method of claim 2 wherein said microsphere is rehydrated from a lyophilized microsphere.
Claim 39
Dependent Claim
20 words
A method of claim 2 wherein said lipid microsphere comprises at least 70 mole percent of at least one lipid.
Claim 40
Dependent Claim
48 words
A method of claim 2 wherein said lipid microsphere comprises at least two lipids wherein said first lipid contains substantially no linkages to a polymer and comprises at least 70 mole percent of the total moles of the microsphere, and wherein said second lipid bears a hydrophilic polymer.
Claim 41
Dependent Claim
38 words
A method of claim 38 wherein said first lipid comprises: (i) a neutral lipid, and (ii) a negatively charged lipid, wherein the amount of said negatively charged lipid is greater than 1 mole percent of total lipids present.
Claim 42
Dependent Claim
13 words
A method of claim 39 wherein said negatively charged lipid is phosphatidic acid.
Claim 43
Dependent Claim
28 words
A method of claim 38 wherein the hydrophilic polymer of said second lipid is selected from the group consisting of polyethyleneglycol, polypropyleneglycol, polyvinylalcohol, and polyvinylpyrrolidone and copolymers thereof.
Claim 44
Dependent Claim
29 words
A method of claim 38 wherein the lipids comprise about 77.5 mole percent dipalmitoyl-phosphatidylcholine, about 12.5 mole percent of dipalmitoyl-phosphatidic acid, and about 10 mole percent of dipalmitoylphosphatidylethanolamine-polyethyleneglycol 5000.
Claim 45
Dependent Claim
29 words
A method of claim 38 wherein the lipids comprise about 82 mole percent dipalmitoylphosphatidyl-choline, about 10 mole percent of dipalmitoylphosphatidic acid, and about 8 mole percent of dipalmitoylphosphatidyl-ethanolamine-polyethyleneglycol 5000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-07-12 | 2003-01-11 | 2003-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-07-12 | 2007-01-11 | 2007-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-07-12 | 2011-01-11 | 2011-07-13 | $7700.00 | Window Closed / Lapsed |