Patent US5824053A successfully refreshed from Google Patents.
Patent US5919187A successfully refreshed from Google Patents.
US5919187A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment
Assignee: University of California, San Diego
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Filing: 1995-09-15
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Granted: 1999-07-06
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Expires: 2015-09-15
Abstract
Abstract A thrombus is generated in an aneurysm, arteriovenous malformation or fistula by means of a catheter having an insulated heating coil coupled to an insulated delivery wire. In one embodiment, two delivery wires are coupled to heating coils to provide a closed circuit. The heating coils may be in the form of a double helix or a single helix in combination with a straight heating coil. The heating coils are permanently connected to the delivery wires. Alternatively, a single insulated heating coil may be attached to a single insulated delivery wire with a uninsulated coil attached to the tip of the insulated heating coil. The electrical circuit is then made through the heating coil and non-insulated electrode coil into the vascular system and to a body electrode. A catheter may also be used for heating blood within the vascular system which is directly flowed into a tumoral mass for the purposes of thermal treatment of cancer.
Inventors
- 👤 Guido Guglielmi
- 👤 Cheng Ji
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:29
CPC Classifications
A; A61; A61M; A61M25/00; A61B; A61B18/00; A61B18/04; A61B18/08; A61B18/082; A61B17/00; A61B17/12; A61B17/12022; A61B17/12099; A61B17/12109; A61B17/12113; A61B17/12131; A61B17/12136; A61B17/1214; A61B17/12145; A61B18/12; A61B18/14; A61B18/1492; A61B2017/00017; A61B2017/00022; A61B2017/00026; A61B17/00234; A61B2017/00292; A61B2017/1205; A61B2017/12054; A61B2017/12063; A61B17/22; A61B2017/22038; A61B2018/00636; A61B2018/00666; A61B2018/00678; A61B2018/00696; A61B2018/00761; A61B2018/00773; A61B2018/00875; A61B2018/00886; A61B18/1206; A61B2018/1226; A61B2018/1246; A61B2018/1253; A61B2018/126; A61B2018/1266; A61B2018/1405; A61B2018/1435; A61B2018/1495; A61B90/00; A61B90/39; A61B2090/3966
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
132 words
An improvement in an endovascular device for use within a vascular system comprising: at least one elongate, flexible, fully insulated and substantially unsupported delivery wire having a first resistance; and at least one elongate, flexible, fully insulated, substantially unsupported, and longitudinally resilient heating coil having a second resistance coupled to said delivery wire, said first resistance being less than said second resistance, wherein said delivery wire and heating coil are both electrically insulated to permit endovascular disposition of said delivery wire and heating coil into said vascular system to deliver heat to blood within said vascular system at a predetermined location, substantially all of said heat being generated by electrical current flowing within said heating coil rather than within said delivery wire, whereby endovascular thermal treatment is provided within said vascular system.
Claim 2
Dependent Claim
132 words
An improvement in an endovascular device for use within a vascular system comprising: at least one elongate, flexible, fully insulated and substantially unsupported delivery wire having a first resistance; and at least one elongate, flexible, fully insulated, substantially unsupported, and longitudinally resilient heating coil having a second resistance coupled to said delivery wire, said first resistance being less than said second resistance, wherein said delivery wire and heating coil are both electrically insulated to permit endovascular disposition of said delivery wire and heating coil into said vascular system to deliver heat to blood within said vascular system at a predetermined location, substantially all of said heat being generated by electrical current flowing within said heating coil rather than within said delivery wire, whereby endovascular thermal treatment is provided within said vascular system.
Claim 3
Dependent Claim
18 words
The improvement of claim 1 wherein said delivery wire and heating coil are permanently coupled to each other.
Claim 4
Dependent Claim
128 words
The improvement of claim 1 further comprising a body electrode in adapted to be in contact with a body having said vascular system and therefore in electrical circuit with said vascular system, and wherein said heating coil has a proximal and distal end, said proximal end being coupled to said delivery wire and further comprising a uninsulated coil coupled to said distal end of said heating coil, said uninsulated coil having an electrical resistance, said electrical resistance of said uninsulated coil being less than said heating coil so that substantially all of said heat generated by said current is generated within said heating coil, said uninsulated coil serving as an endovascular electrode to provide completion of circuit through said delivery wire, and heating coil to said body electrode.
Claim 5
Dependent Claim
18 words
The improvement of claim 3 wherein said delivery wire and heating coil are permanently coupled to each other.
Claim 6
Dependent Claim
22 words
The improvement of claim 1 further comprising a current source coupled to said delivery wire for controllably delivering said electrical current thereto.
Claim 7
Dependent Claim
207 words
An improvement in an endovascular device for use within a vascular system comprising: at least one delivery wire having a first resistance; at least one heating coil having a second resistance coupled to said delivery wire, said first resistance being less than said second resistance, wherein said delivery wire and heating coil are both electrically insulated to permit endovascular disposition of said delivery wire and heating coil into said vascular system to deliver heat to a fluid within said vascular system at a predetermined location, substantially all of said heat being generated by electrical current flowing within said heating coil rather than within said delivery wire; and at least two delivery wires and at least two heating coils each having a proximal and distal end, said proximal end of each of said heating coils being coupled to corresponding ones of said two delivery wires, said distal end of said two heating coils being coupled together to provide a continuous circuit through a first one of said two delivery wires to a first one of said two heating coils, to a second one of said two heating coils, and to a second one of said two delivery wires, whereby endovascular thermal treatment is provided within said vascular system.
Claim 8
Dependent Claim
207 words
An improvement in an endovascular device for use within a vascular system comprising: at least one delivery wire having a first resistance; at least one heating coil having a second resistance coupled to said delivery wire, said first resistance being less than said second resistance, wherein said delivery wire and heating coil are both electrically insulated to permit endovascular disposition of said delivery wire and heating coil into said vascular system to deliver heat to a fluid within said vascular system at a predetermined location, substantially all of said heat being generated by electrical current flowing within said heating coil rather than within said delivery wire; and at least two delivery wires and at least two heating coils each having a proximal and distal end, said proximal end of each of said heating coils being coupled to corresponding ones of said two delivery wires, said distal end of said two heating coils being coupled together to provide a continuous circuit through a first one of said two delivery wires to a first one of said two heating coils, to a second one of said two heating coils, and to a second one of said two delivery wires, whereby endovascular thermal treatment is provided within said vascular system.
Claim 9
Dependent Claim
20 words
The improvement of claim 6 wherein said two heating coils are each helical and together form a double helical tip.
Claim 10
Dependent Claim
18 words
The improvement of claim 7 wherein said delivery wire and heating coil are permanently coupled to each other.
Claim 11
Dependent Claim
25 words
The improvement of claim 6 wherein one of said two delivery wires is helical and the other one of said two delivery wires is nonhelical.
Claim 12
Independent Claim
117 words
A method for selectively heating tissue at a predetermined location within a vascular system comprising: disposing a microcatheter within said vascular system at said predetermined location; disposing from said microcatheter at said predetermined location at least one insulated heating coil, said insulated heating coil being electrically coupled to an insulated delivery wire included within said microcatheter and extending exteriorly to said vascular system; applying electrical current through said delivery wire to said heating coil to heat blood within said vascular system at said predetermined location to thermally heat tissue in contact with said blood; and withdrawing said microcatheter and delivery wire from said vascular system, whereby thermal heating of tissue within said vascular system is selectively formed.
Claim 13
Independent Claim
117 words
A method for selectively heating tissue at a predetermined location within a vascular system comprising: disposing a microcatheter within said vascular system at said predetermined location; disposing from said microcatheter at said predetermined location at least one insulated heating coil, said insulated heating coil being electrically coupled to an insulated delivery wire included within said microcatheter and extending exteriorly to said vascular system; applying electrical current through said delivery wire to said heating coil to heat blood within said vascular system at said predetermined location to thermally heat tissue in contact with said blood; and withdrawing said microcatheter and delivery wire from said vascular system, whereby thermal heating of tissue within said vascular system is selectively formed.
Claim 14
Dependent Claim
28 words
The method of claim 10 where disposing a heating coil in said vascular system comprises disposing at least two insulated heating coils connected together in an electrical circuit.
Claim 15
Dependent Claim
25 words
The method of claim 10 where applying said current to said delivery wire and heating coil resistively generates heat substantially only within said heating coil.
Claim 16
Dependent Claim
64 words
The method of claim 10 where applying current to said delivery wire and heating coil further comprises applying current through said heating coil to an uninsulated coil tip in electrical contact with said blood in said vascular system to complete an electrical circuit through said delivery wire, heating coil and coil tip electrode to a body electrode in electrical communication with said vascular system.
Claim 17
Independent Claim
104 words
A method for treating cancer comprising: disposing a microcatheter within said vascular system at said predetermined location in a blood flow to a tumoral mass; disposing from said microcatheter at said predetermined location at least one insulated heating coil, said insulated heating coil being electrically coupled to an insulated delivery wire included within said microcatheter and extending exteriorly to said vascular system; and applying an electrical current through said delivery wire to said heating coil to heat said blood flow within said vascular system at said predetermined location to thermally stress said tumoral mass downstream, whereby thermal treatment of said tumoral mass is effected.
Claim 18
Independent Claim
104 words
A method for treating cancer comprising: disposing a microcatheter within said vascular system at said predetermined location in a blood flow to a tumoral mass; disposing from said microcatheter at said predetermined location at least one insulated heating coil, said insulated heating coil being electrically coupled to an insulated delivery wire included within said microcatheter and extending exteriorly to said vascular system; and applying an electrical current through said delivery wire to said heating coil to heat said blood flow within said vascular system at said predetermined location to thermally stress said tumoral mass downstream, whereby thermal treatment of said tumoral mass is effected.
Claim 19
Dependent Claim
27 words
The method of claim 14 where disposing said microcather comprises disposing at least two insulated heating coils connected together in an electrical circuit in said vascular system.
Claim 20
Dependent Claim
25 words
The method of claim 14 where applying said current to said delivery wire and heating coil resistively generates heat substantially only within said heating coil.
Claim 21
Dependent Claim
64 words
The method of claim 14 where applying current to said delivery wire and heating coil further comprises applying current through said heating coil to an uninsulated coil tip in electrical contact with said blood in said vascular system to complete an electrical circuit through said delivery wire, heating coil and coil tip electrode to a body electrode in electrical communication with said vascular system.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-07-05 | 2003-01-04 | 2003-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-07-05 | 2007-01-04 | 2007-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-07-05 | 2011-01-04 | 2011-07-06 | $7700.00 | Window Closed / Lapsed |