US5906599A — Device for delivering biological agents

Claim 1

Independent Claim 120 words

A biological agent delivery device comprising: a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; a flexible membrane having a lateral support surface for supporting a biological agent, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; and a displacement member disposed within the wall of the cannula for displacing the support surface of the membrane laterally with respect to the cannula to deliver the biological agent.

Claim 2

Dependent Claim 120 words

A biological agent delivery device comprising: a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; a flexible membrane having a lateral support surface for supporting a biological agent, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; and a displacement member disposed within the wall of the cannula for displacing the support surface of the membrane laterally with respect to the cannula to deliver the biological agent.

Claim 3

Dependent Claim 31 words

The delivery device of claim 1 further comprising an outer tube mounted concentric with the cannula for relative movement with respect to the cannula or enclosing or exposing the cannula notch.

Claim 4

Dependent Claim 14 words

The delivery device of claim 1 in which the displacement member comprises a piston.

Claim 5

Dependent Claim 16 words

The delivery device of claim 1 in which the displacement member comprises a volume of fluid.

Claim 6

Dependent Claim 13 words

The delivery device of claim 4 in which the fluid is a liquid.

Claim 7

Dependent Claim 13 words

The delivery device of claim 4 in which the fluid is a gas.

Claim 8

Dependent Claim 23 words

The delivery device of claim 1 in which the support surface forms a pouch when the flexible membrane is in a non-displaced state.

Claim 9

Dependent Claim 12 words

The delivery device of claim 7 in which the pouch is preformed.

Claim 10

Dependent Claim 44 words

The delivery device of claim 1 in which the flexible membrane extends within the cannula and comprises a tubular member having a closed distal end, the support surface of the membrane being located near said closed distal end and positioned within the cannula notch.

Claim 11

Dependent Claim 21 words

The delivery device of claim 1 further comprising fiber optics within the cannula for delivering radiation to a desired tissue site.

Claim 12

Dependent Claim 24 words

The delivery device of claim 10 further comprising a lens associated with the fiber optics for enabling viewing of regions external to the cannula.

Claim 13

Dependent Claim 144 words

A biological agent delivery device comprising: a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; a flexible membrane having a lateral support surface for supporting a biological agent, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; and a displacement member disposed within the wall of the cannula for displacing the support surface of the membrane laterally with respect to the cannula to displace the biological agent; and an outer tube mounted concentric with the cannula for relative movement with respect to the cannula for enclosing or exposing the cannula notch.

Claim 14

Dependent Claim 144 words

A biological agent delivery device comprising: a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; a flexible membrane having a lateral support surface for supporting a biological agent, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; and a displacement member disposed within the wall of the cannula for displacing the support surface of the membrane laterally with respect to the cannula to displace the biological agent; and an outer tube mounted concentric with the cannula for relative movement with respect to the cannula for enclosing or exposing the cannula notch.

Claim 15

Dependent Claim 14 words

The delivery device of claim 12 in which the displacement member comprises a piston.

Claim 16

Dependent Claim 16 words

The delivery device of claim 12 in which the displacement member comprises a volume of fluid.

Claim 17

Dependent Claim 13 words

The delivery device of claim 14 in which the fluid is a liquid.

Claim 18

Dependent Claim 13 words

The delivery device of claim 14 in which the fluid is a gas.

Claim 19

Dependent Claim 23 words

The delivery device of claim 12 in which the support surface forms a pouch when the flexible membrane is in a non-displaced state.

Claim 20

Dependent Claim 12 words

The delivery device of claim 17 in which the pouch is preformed.

Claim 21

Dependent Claim 44 words

The delivery device of claim 12 in which the flexible membrane extends within the cannula and comprises a tubular member having a closed distal end, the support surface of the membrane being located near said closed distal end and positioned within the cannula notch.

Claim 22

Dependent Claim 21 words

The delivery device of claim 12 further comprising fiber optics within the cannula for delivering radiation to a desired tissue site.

Claim 23

Dependent Claim 24 words

The delivery device of claim 20 further comprising a lens associated with the fiber optics for enabling viewing of regions external to the cannula.

Claim 24

Independent Claim 145 words

A method of delivering a biological agent to a tissue site comprising the steps of: providing a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; supporting a biological agent on a lateral support surface of a flexible membrane, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; inserting the distal end of the cannula into the tissue site; and laterally displacing the support surface of the membrane with respect to the cannula with a displacement member disposed within the wall of the cannula to deliver the biological agent to the tissue site.

Claim 25

Independent Claim 145 words

A method of delivering a biological agent to a tissue site comprising the steps of: providing a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; supporting a biological agent on a lateral support surface of a flexible membrane, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; inserting the distal end of the cannula into the tissue site; and laterally displacing the support surface of the membrane with respect to the cannula with a displacement member disposed within the wall of the cannula to deliver the biological agent to the tissue site.

Claim 26

Dependent Claim 36 words

The method of claim 22 further comprising the step of enclosing the cannula notch with an outer tube mounted concentric with the cannula before insertion of the distal end of the cannula into the tissue site.

Claim 27

Dependent Claim 35 words

The method of claim 23 further comprising the step of extending the cannula to expose the cannula notch beyond the outer tube after insertion of the distal end of the cannula into the tissue site.

Claim 28

Dependent Claim 47 words

The method of claim 22 further comprising the step of extending the flexible membrane within the cannula, the membrane comprising a tubular member having a closed distal end, the support surface of the membrane being located near said closed distal end and positioned within the cannula notch.

Claim 29

Dependent Claim 20 words

The method of claim 22 further comprising the step of delivering radiation to a desired tissue site with fiber optics.

Claim 30

Dependent Claim 19 words

The method of claim 22 further comprising the step of viewing regions external to the cannula with fiber optics.

Claim 31

Dependent Claim 21 words

The method of claim 22 further comprising the step of forming the support surface of the flexible membrane into a pouch.

Claim 32

Dependent Claim 119 words

A subcutaneous delivery device comprising: a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; a flexible membrane having a lateral support surface supporting a product to be delivered, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; and a displacement member disposed within the wall of the cannula for displacing the support surface of the membrane laterally with respect to the cannula to deliver the product.

Claim 33

Dependent Claim 119 words

A subcutaneous delivery device comprising: a cannula having a longitudinally extending wall and a rigid closed pointed tip at a distal end with a notch in said wall near the distal end forming a lateral opening in the cannula wall; a flexible membrane having a lateral support surface supporting a product to be delivered, the membrane being disposed within the cannula notch, the support surface forming a laterally facing pouch capable of being displaced laterally inwardly and outwardly within the cannula notch for containing and laterally displacing the biological agent; and a displacement member disposed within the wall of the cannula for displacing the support surface of the membrane laterally with respect to the cannula to deliver the product.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2002-05-24	2002-11-23	2003-05-25	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2006-05-24	2006-11-23	2007-05-25	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2010-05-24	2010-11-23	2011-05-25	$7700.00	Window Closed / Lapsed

Device for delivering biological agents

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