US5873811A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition containing a radioactive component for treatment of vessel wall
Assignee: Boston Scientific Scimed Inc
•
Filing: 1997-01-10
•
Granted: 1999-02-23
•
Expires: 2017-01-10
Abstract
Abstract A method and composition for inhibiting restenosis. The composition includes an adhesive or polymeric material having a radioactive component dispersed therethrough. A biologically compatible adhesive including a radioactive material is applied to a vessel region where inhibition of restenosis is desired in a preferred method. In one composition, the radioactive material is admixed with the adhesive. In another composition, the radioactive material is chemically bonded to a polymeric adhesive. The adhesive is preferably cured in place. The radioactive material has a preferred half life of less than six months. In one method, the application of adhesive is followed by stent placement, leaving radioactive adhesive extending beyond both stent ends. The application can include forcing adhesive from a double walled balloon having a porous outer wall.
Inventors
- 👤 Lixiao Wang
- 👤 Roger N. Hastings
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 22:41
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61K; A61K51/00; A61K51/12; A61K51/1279; A61K51/1282; A61M; A61M25/00; A61M25/10; A61M25/104; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1002; A61P; A61P9/00; A61P9/08; A61B; A61B17/00; A61B17/22; A61B2017/22001; A61B2017/22002; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30316; A61F2002/30329; A61F2002/30448; A61F2220/00; A61F2220/0025; A61F2220/005; A61M2025/1043; A61M2025/105; A61M29/00; A61M29/02
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
29 words
A method for inhibiting restenosis at a vessel wall region comprising the steps: providing an adhesive including a radioactive material; and applying said adhesive to said vessel wall region.
Claim 2
Independent Claim
29 words
A method for inhibiting restenosis at a vessel wall region comprising the steps: providing an adhesive including a radioactive material; and applying said adhesive to said vessel wall region.
Claim 3
Dependent Claim
16 words
A method as recited in claim 1 wherein said radioactive material is admixed with said adhesive.
Claim 4
Dependent Claim
17 words
A method as recited in claim 1 wherein said radioactive material is chemically bonded to said adhesive.
Claim 5
Dependent Claim
29 words
A method as recited in claim 1 wherein said radioactive material is selected from the group consisting of: Phosphorus 32, Yttrium 90, Iodine 125, Iridium 192, and mixtures thereof.
Claim 6
Dependent Claim
23 words
A method as recited in claim 1 wherein said adhesive includes polymeric material and said radioactive material is bonded to said polymeric material.
Claim 7
Dependent Claim
40 words
A method as recited in claim 1 wherein said applying step includes: providing a catheter including adhesive application means; advancing said catheter adhesive application means to said vessel wall region; and applying said adhesive utilizing said catheter adhesive application means.
Claim 8
Dependent Claim
95 words
A method as recited in claim 6 wherein said adhesive application means is a balloon catheter including a first lumen having a distal opening, an inner inflatable envelope and an outer envelope having a space therebetween, said outer envelope having a plurality of holes therein, said outer envelope having an inner wall in fluid communication with said first lumen, said applying step further including: inflating said first envelope within said vessel wall region; and forcing said adhesive distally from said first lumen distal opening into said space, through said holes to said vessel wall region.
Claim 9
Dependent Claim
40 words
A method as recited in claim 7 wherein said catheter includes a proximal end and said first lumen includes a proximal end and a proximal opening, said forcing step further including injecting said adhesive into said first lumen proximal opening.
Claim 10
Dependent Claim
17 words
A method as recited in claim 7 further comprising placing a stent within said vessel wall region.
Claim 11
Dependent Claim
37 words
A composition for use in inhibiting restenosis in a body comprising an adhesive composition and a radioactive material dispersed therethrough, wherein the adhesive composition is adapted to be absorbed by the body after a period of time.
Claim 12
Dependent Claim
37 words
A composition for use in inhibiting restenosis in a body comprising an adhesive composition and a radioactive material dispersed therethrough, wherein the adhesive composition is adapted to be absorbed by the body after a period of time.
Claim 13
Dependent Claim
14 words
The composition of claim 10 wherein said radioactive material is admixed with said adhesive.
Claim 14
Dependent Claim
17 words
The composition of claim 10 wherein said radioactive material is part of the structure of said adhesive.
Claim 15
Dependent Claim
27 words
The composition of claim 10 wherein said radioactive material is selected from the group consisting of: Phosphorus 32, Yttrium 90, Iodine 125, Iridium 192, and mixtures thereof.
Claim 16
Dependent Claim
23 words
The composition of claim 10 wherein said adhesive composition includes a polymeric material and said radioactive material is bonded to said polymeric material.
Claim 17
Dependent Claim
36 words
A composition for use in inhibiting restenosis comprising an adhesive composition and a radioactive material dispersed therethrough, wherein said adhesive composition is a moisture cure adhesive selected from the group consisting of: fibrin glue and cyanoacrylates.
Claim 18
Dependent Claim
36 words
A composition for use in inhibiting restenosis comprising an adhesive composition and a radioactive material dispersed therethrough, wherein said adhesive composition is a moisture cure adhesive selected from the group consisting of: fibrin glue and cyanoacrylates.
Claim 19
Dependent Claim
17 words
The composition of claim 15 wherein said fibrin glue includes fibrinogen, thrombin, calcium chloride and factor VIII.
Claim 20
Dependent Claim
21 words
The composition of claim 15 wherein said cyanoacrylate is selected from the group consisting of: butyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, octyl-2-cyanoacrylate, and mixtures thereof.
Claim 21
Independent Claim
46 words
A method for inhibiting cell growth in a tissue region of a human body comprising the steps: providing an adhesive including a radioactive material; applying said adhesive to said tissue region; and allowing said adhesive to cure while said adhesive is applied to said tissue region.
Claim 22
Independent Claim
46 words
A method for inhibiting cell growth in a tissue region of a human body comprising the steps: providing an adhesive including a radioactive material; applying said adhesive to said tissue region; and allowing said adhesive to cure while said adhesive is applied to said tissue region.
References Cited (Backward Citations)
US1645599A
Cited
US4799479A
Cited
US5030194A
Cited
US5084001A
Cited
US4889707A
Cited
US5213580A
Cited
US5674287A
Cited
US5575815A
Cited
US5634946A
Cited
US5147282A
Cited
EP0433011B1
Cited
EP0593136A1
Cited
US5176617A
Cited
US5059166A
Cited
US5199939B1
Cited
US5199939A
Cited
US5662609A
Cited
US5328471A
Cited
US5213561A
Cited
US5092834A
Cited
US5484384A
Cited
EP0497495A2
Cited
US5354257A
Cited
DE9102312U1
Cited
US5558642A
Cited
US5302168A
Cited
WO1993004735A1
Cited
US5411466A
Cited
WO1993021970A1
Cited
US5421826A
Cited
US5417653A
Cited
US5308356A
Cited
US5643171A
Cited
WO1994025106A1
Cited
WO1994026205A1
Cited
US5674177A
Cited
EP0633041A1
Cited
US5540659A
Cited
WO1995007732A1
Cited
US5498227A
Cited
US5545132A
Cited
WO1995019807A1
Cited
US5503613A
Cited
US5618266A
Cited
US5556389A
Cited
WO1995026681A1
Cited
EP0688580A1
Cited
WO1996006654A1
Cited
WO1996010436A1
Cited
WO1996013303A1
Cited
US5683345A
Cited
WO1996014898A1
Cited
US5616114A
Cited
US5662580A
Cited
WO1996017654A1
Cited
WO1996022121A1
Cited
US5653683A
Cited
US5605530A
Cited
WO1996029943A1
Cited
WO1997018012A1
Cited
WO1997040889A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-22 | 2002-08-24 | 2003-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-22 | 2006-08-24 | 2007-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-22 | 2010-08-24 | 2011-02-23 | $7700.00 | Window Closed / Lapsed |