US4889707A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method for radiation synovectomy of arthritic joints
Assignee: University of Missouri System
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Filing: 1988-01-29
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Granted: 1989-12-26
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Expires: 2008-01-29
Abstract
Abstract Radioactive microspheres for radiation synovectomy of arithmetic joints in a mammal comprise a biodegradable glass material and a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout the glass material. The biodegradable glass material may be lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium, aluminoborate, potassium germanate or potassium aluminogermanate and the beta radiation emitting radioisotope may be samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 or yttrium-90. Methods for preparing such microspheres and for carrying out radiation synovectomy of arthritic joints utilizing such microspheres are also disclosed.
Inventors
- 👤 Delbert E. Day
- 👤 Gary J. Ehrhardt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A61K51/00; A61K51/12; A61K51/1258; A61K2121/00
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
95 words
A method for carrying out radiation synovectomy of arthritic joints which comprises administering to a mammal affected with an arthritic joint an effective amount of microspheres comprising a biologically compatible material selected from the group consisting of aluminosilicate, magnesium aluminosilicate, lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate and potassium aluminogermanate and containing a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout said glass material and being selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90.
Claim 2
Independent Claim
95 words
A method for carrying out radiation synovectomy of arthritic joints which comprises administering to a mammal affected with an arthritic joint an effective amount of microspheres comprising a biologically compatible material selected from the group consisting of aluminosilicate, magnesium aluminosilicate, lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate and potassium aluminogermanate and containing a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout said glass material and being selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90.
Claim 3
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium silicate and said radioisotope is samarium-153.
Claim 4
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminosilicate and said radioisotope is samarium-153.
Claim 5
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminoborate and said radioisotope is samarium-153.
Claim 6
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass aterial is lithium silicate and said radioisotope is holmium-166.
Claim 7
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminosilicate and said radioisotope is holmium-166.
Claim 8
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminoborate and said radioisotope is holmium-166.
Claim 9
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is magnesium aluminosilicate and said radioisotope is samarium-153.
Claim 10
Dependent Claim
19 words
A method as set forth in claim 1 wherein said glass material is aluminosilicate and said radioisotope is samarium-153.
Claim 11
Dependent Claim
19 words
A method as set forth in claim 1 wherein said glass material is aluminosilicate and said radioisotope is yttrium-90.
Claim 12
Dependent Claim
24 words
A method as set forth in claim 1 wherein said microsphere has a diameter in the range of about 3 to about 30 micrometers.
Claim 13
Dependent Claim
61 words
A radioactive microsphere for radiation synovectomy of arthritic joints in a mammal comprising a biologically compatible glass material selected from the group consisting of magnesium aluminosilicate and aluminosilicate and containing a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout said glass material and being selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186 and rhenium-188.
Claim 14
Dependent Claim
61 words
A radioactive microsphere for radiation synovectomy of arthritic joints in a mammal comprising a biologically compatible glass material selected from the group consisting of magnesium aluminosilicate and aluminosilicate and containing a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout said glass material and being selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186 and rhenium-188.
Claim 15
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 12 wherein said glass material is magnesium aluminosilicate and said radioisotope is samarium-153.
Claim 16
Dependent Claim
20 words
A radioactive microsphere as set forth in claim 12 wherein said glass material is aluminosilicate and said radioisotope is samarium-153.
Claim 17
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 12 wherein said glass material is magnesium aluminosilicate and said radioisotope is holmium-166.
Claim 18
Dependent Claim
20 words
A radioactive microsphere as set forth in claim 12 wherein said glass material is aluminosilicate and said radioisotope is holmium-166.
Claim 19
Dependent Claim
25 words
A radioactive microsphere as set forth in claim 12 wherein said microsphere has a diameter in the range of about 3 to about 30 micrometers.
Claim 20
Dependent Claim
68 words
A radioactive microsphere for radiation synovectomy of arthritic joints in a mammal comprising a biodegradable glass material selected from the group consisting of lithium silicate, lithium alumino-silicate, lithium aluminoborate, lithium germanate and lithium aluminogermanate and containing a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout said glass material and being selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90.
Claim 21
Dependent Claim
68 words
A radioactive microsphere for radiation synovectomy of arthritic joints in a mammal comprising a biodegradable glass material selected from the group consisting of lithium silicate, lithium alumino-silicate, lithium aluminoborate, lithium germanate and lithium aluminogermanate and containing a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout said glass material and being selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90.
Claim 22
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 18 wherein said glass material is lithium silicate and said radioisotope is samarium-153.
Claim 23
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 18 wherein said glass material is lithium aluminosilicate and said radioisotope is samarium-153.
Claim 24
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 18 wherein said glass material is lithium aluminoborate and said radioisotope is samarium-153.
Claim 25
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 18 wherein said glass material is lithium silicate and said radioisotope is holmium-166.
Claim 26
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 18 wherein said glass material is lithium aluminosilicate and said radioisotope is holmium-166.
Claim 27
Dependent Claim
21 words
A radioactive microsphere as set forth in claim 18 wherein said glass material is lithium aluminoborate and said radioisotope is holmium-166.
Claim 28
Dependent Claim
25 words
A radioactive microsphere as set forth in claim 18 wherein said microsphere has a diameter in the range of about 3 to about 30 micrometers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-25 | 1993-06-26 | 1993-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-25 | 1997-06-26 | 1997-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-25 | 2001-06-26 | 2001-12-26 | $7700.00 | Window Closed / Lapsed |