US4517006A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composite materials comprising water-soluble glass particles
Assignee: STC PLC
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Filing: 1982-11-17
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Granted: 1985-05-14
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Expires: 2002-11-17
Abstract
Abstract A composite material for the controlled release of an active substrate comprises a relatively insoluble, e.g. polymeric, matrix (11) in which a soluble particulate material (12) is dispersed. When the composite is placed in an aqueous medium dissolution of the particulate material substantially increases the water permeability of the matrix. This effect may be used to provide for the controlled release of an active material into the aqueous medium.
Inventors
- 👤 Cyril F. Drake
- 👤 Ronald Jones
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:48
CPC Classifications
C; C05; C05G; C05G5/00; C05G5/40; A; A01; A01N; A01N25/00; A01N25/12; A01N25/26; A01N25/34; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2009; A61K9/70; A61K9/7023; Y; Y10; Y10S; Y10S428/00; Y10S428/913; Y10S71/00; Y10S71/904; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249954; Y10T428/249986; Y10T428/29; Y10T428/2913; Y10T428/2927; Y10T428/2982; Y10T428/2991; Y10T428/2993; Y10T428/2996; Y10T442/00; Y10T442/20; Y10T442/2525
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
186 words
A coherent composite structure releasably incorporating an active material therein, said composite structure comprising a polymeric matrix material and a particulate glass composition dispersed in said matrix material, said polymeric matrix material being essentially insoluble in aqueous medium and said particulate glass composition being soluble at a controlled dissolution rate in said aqueous medium whereby said composite structure shields said active material from release until contacted by said aqueous medium and when said composite structure is contacted by said aqueous medium, said particulate glass composition dissolves at a controlled rate thereby increasing the aqueous permeability of said composite structure to release said active material incorporated therein at a controlled rate, said particulate glass composition consisting essentially of from 50-75 mole percent of phosphorus pentoxide as a glass forming oxide; from 1-20 mole percent of an alkali metal oxide as the principal glass modifier, the remainder including from 1-25 mole percent of an oxide selected from the group consisting of an alkaline earth metal oxide, an oxide of a metal of Group III A of the Periodic Table, a transition metal oxide and combinations of the foregoing.
Claim 2
Dependent Claim
186 words
A coherent composite structure releasably incorporating an active material therein, said composite structure comprising a polymeric matrix material and a particulate glass composition dispersed in said matrix material, said polymeric matrix material being essentially insoluble in aqueous medium and said particulate glass composition being soluble at a controlled dissolution rate in said aqueous medium whereby said composite structure shields said active material from release until contacted by said aqueous medium and when said composite structure is contacted by said aqueous medium, said particulate glass composition dissolves at a controlled rate thereby increasing the aqueous permeability of said composite structure to release said active material incorporated therein at a controlled rate, said particulate glass composition consisting essentially of from 50-75 mole percent of phosphorus pentoxide as a glass forming oxide; from 1-20 mole percent of an alkali metal oxide as the principal glass modifier, the remainder including from 1-25 mole percent of an oxide selected from the group consisting of an alkaline earth metal oxide, an oxide of a metal of Group III A of the Periodic Table, a transition metal oxide and combinations of the foregoing.
Claim 3
Dependent Claim
56 words
The composite structure of claim 1, wherein a portion, not exceeding 10 mole percent of the phosphorus pentoxide in said particulate glass composition is replaced by another glass-forming oxide selected from the group consisting of SiO 3 , B 2 O 3 , GeO 2 , As 2 O 3 and Sb 2 O 3 .
Claim 4
Dependent Claim
25 words
A structure as claimed in claim 1 and in the form of a monolithic block woven or single fibres, a sheet, a film or granules.
Claim 5
Dependent Claim
34 words
A structure as claimed in claim 1, wherein the active material selected from the group consisting of fertilisers, selective or non-selective herbicides, insecticides, pheromones, molluscides, larvicides, nematocides, fungicides, algicides, slimicides, rodenticides, or mixtures thereof.
Claim 6
Dependent Claim
30 words
A structure as claimed in claim 1, wherein the active material is selected from the group consisting of nutrients, prophylactic agents, therapeutic agents, antibiotics, antiseptic agents, parasiticides, hormones, and contraceptives.
Claim 7
Dependent Claim
20 words
A structure as claimed in claim 1, wherein the particulate glass material comprises 50-90% by volume of the composite material.
Claim 8
Dependent Claim
30 words
A therapeutic device being an implant or percutaneous device, a bolus or other device capable of oral, rectal or surgical administration formed from a structure as claimed in claim 1.
Claim 9
Dependent Claim
27 words
A device as claimed in claim 7, wherein the composite is in the form of a film or sheet comprising a surface coating on a solid body.
Claim 10
Dependent Claim
26 words
A device as claimed in claim 7, wherein the structure is in the form of a body containing one or more cavities each containing active material.
Claim 11
Dependent Claim
16 words
A device as claimed in claim 9, wherein the active material is a drug or medicament.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-05-13 | 1988-11-12 | 1989-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-05-13 | 1992-11-12 | 1993-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-05-13 | 1996-11-12 | 1997-05-14 | $7700.00 | Window Closed / Lapsed |