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US4517006A Expired / Lapsed US ⏱️ 0.0 years remaining

Composite materials comprising water-soluble glass particles

Assignee: STC PLC
•
Filing: 1982-11-17
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Granted: 1985-05-14
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Expires: 2002-11-17
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Abstract

Abstract A composite material for the controlled release of an active substrate comprises a relatively insoluble, e.g. polymeric, matrix (11) in which a soluble particulate material (12) is dispersed. When the composite is placed in an aqueous medium dissolution of the particulate material substantially increases the water permeability of the matrix. This effect may be used to provide for the controlled release of an active material into the aqueous medium.

Inventors

  • 👤 Cyril F. Drake
  • 👤 Ronald Jones

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 23:48
CPC Classifications
C; C05; C05G; C05G5/00; C05G5/40; A; A01; A01N; A01N25/00; A01N25/12; A01N25/26; A01N25/34; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2009; A61K9/70; A61K9/7023; Y; Y10; Y10S; Y10S428/00; Y10S428/913; Y10S71/00; Y10S71/904; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249954; Y10T428/249986; Y10T428/29; Y10T428/2913; Y10T428/2927; Y10T428/2982; Y10T428/2991; Y10T428/2993; Y10T428/2996; Y10T442/00; Y10T442/20; Y10T442/2525

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 186 words
A coherent composite structure releasably incorporating an active material therein, said composite structure comprising a polymeric matrix material and a particulate glass composition dispersed in said matrix material, said polymeric matrix material being essentially insoluble in aqueous medium and said particulate glass composition being soluble at a controlled dissolution rate in said aqueous medium whereby said composite structure shields said active material from release until contacted by said aqueous medium and when said composite structure is contacted by said aqueous medium, said particulate glass composition dissolves at a controlled rate thereby increasing the aqueous permeability of said composite structure to release said active material incorporated therein at a controlled rate, said particulate glass composition consisting essentially of from 50-75 mole percent of phosphorus pentoxide as a glass forming oxide; from 1-20 mole percent of an alkali metal oxide as the principal glass modifier, the remainder including from 1-25 mole percent of an oxide selected from the group consisting of an alkaline earth metal oxide, an oxide of a metal of Group III A of the Periodic Table, a transition metal oxide and combinations of the foregoing.
Claim 2
Dependent Claim 186 words
A coherent composite structure releasably incorporating an active material therein, said composite structure comprising a polymeric matrix material and a particulate glass composition dispersed in said matrix material, said polymeric matrix material being essentially insoluble in aqueous medium and said particulate glass composition being soluble at a controlled dissolution rate in said aqueous medium whereby said composite structure shields said active material from release until contacted by said aqueous medium and when said composite structure is contacted by said aqueous medium, said particulate glass composition dissolves at a controlled rate thereby increasing the aqueous permeability of said composite structure to release said active material incorporated therein at a controlled rate, said particulate glass composition consisting essentially of from 50-75 mole percent of phosphorus pentoxide as a glass forming oxide; from 1-20 mole percent of an alkali metal oxide as the principal glass modifier, the remainder including from 1-25 mole percent of an oxide selected from the group consisting of an alkaline earth metal oxide, an oxide of a metal of Group III A of the Periodic Table, a transition metal oxide and combinations of the foregoing.
Claim 3
Dependent Claim 56 words
The composite structure of claim 1, wherein a portion, not exceeding 10 mole percent of the phosphorus pentoxide in said particulate glass composition is replaced by another glass-forming oxide selected from the group consisting of SiO 3 , B 2 O 3 , GeO 2 , As 2 O 3 and Sb 2 O 3 .
Claim 4
Dependent Claim 25 words
A structure as claimed in claim 1 and in the form of a monolithic block woven or single fibres, a sheet, a film or granules.
Claim 5
Dependent Claim 34 words
A structure as claimed in claim 1, wherein the active material selected from the group consisting of fertilisers, selective or non-selective herbicides, insecticides, pheromones, molluscides, larvicides, nematocides, fungicides, algicides, slimicides, rodenticides, or mixtures thereof.
Claim 6
Dependent Claim 30 words
A structure as claimed in claim 1, wherein the active material is selected from the group consisting of nutrients, prophylactic agents, therapeutic agents, antibiotics, antiseptic agents, parasiticides, hormones, and contraceptives.
Claim 7
Dependent Claim 20 words
A structure as claimed in claim 1, wherein the particulate glass material comprises 50-90% by volume of the composite material.
Claim 8
Dependent Claim 30 words
A therapeutic device being an implant or percutaneous device, a bolus or other device capable of oral, rectal or surgical administration formed from a structure as claimed in claim 1.
Claim 9
Dependent Claim 27 words
A device as claimed in claim 7, wherein the composite is in the form of a film or sheet comprising a surface coating on a solid body.
Claim 10
Dependent Claim 26 words
A device as claimed in claim 7, wherein the structure is in the form of a body containing one or more cavities each containing active material.
Claim 11
Dependent Claim 16 words
A device as claimed in claim 9, wherein the active material is a drug or medicament.

References Cited (Backward Citations)

US4111922A Cited
US3959556A Cited
US4123248A Cited
US4349025A Cited
US4343853A Cited
US4473545A Cited
US4401712A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-05-13 1988-11-12 1989-05-14 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-05-13 1992-11-12 1993-05-14 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-05-13 1996-11-12 1997-05-14 $7700.00 Window Closed / Lapsed

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