Patent US1961578A successfully refreshed from Google Patents.
US4745907A
Expired / Lapsed
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System and method for delivering insoluble materials into a living body
Assignee: Theragenics Corp
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Filing: 1987-09-16
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Granted: 1988-05-24
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Expires: 2007-09-16
Abstract
Abstract To deliver a controlled dosage of an insoluble material into a living body, the material is provided in measured amounts in vials, and a system is provided for flushing the entire content of insoluble materials from the vial into the body. Insoluble radioactive material, such as glass microspheres incorporating radioactive isotopes, are packaged in a plurality of vials, preferably with different amounts of material. An accurate dosage of radioactivity can be delivered by administering the entire contents of one or more vial(s) according to the sum of radioactivity in selected vials as determined by the initial measurement of radioactivity and by the natural half-life of the isotope.
Inventors
- 👤 John L. Russel, Jr.
- 👤 John L. Carden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:04
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/1414; A61M5/007; A61M2005/1401; A61M2005/1403; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N2005/1019; A61N2005/1021; A61N5/1007; Y; Y10; Y10S; Y10S604/00; Y10S604/903
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
124 words
A vial assembly for use in a system for delivering an amount of glass microspheres containing a radioactive isotope entrained in a liquid having a lower density than said microspheres into the body of a living mammal, said vial assembly comprising: a vial having a bottom wall and a sidewall defining an interior which is substantially symmetrical about a vertical axis, an open mouth at the top of said vial, said bottom wall having a surface that is substantially in the shape of an inverted cone to define a depression for receiving a supply of said microspheres and said sidewall having a substantially smooth inner surface; a supply of said microspheres disposed in said depression; and a septum closing the mouth of said vial.
Claim 2
Dependent Claim
124 words
A vial assembly for use in a system for delivering an amount of glass microspheres containing a radioactive isotope entrained in a liquid having a lower density than said microspheres into the body of a living mammal, said vial assembly comprising: a vial having a bottom wall and a sidewall defining an interior which is substantially symmetrical about a vertical axis, an open mouth at the top of said vial, said bottom wall having a surface that is substantially in the shape of an inverted cone to define a depression for receiving a supply of said microspheres and said sidewall having a substantially smooth inner surface; a supply of said microspheres disposed in said depression; and a septum closing the mouth of said vial.
Claim 3
Independent Claim
234 words
A system for delivering an amount of glass microspheres containing a radioactive isotope entrained in a liquid having a lower density than said microspheres into the body of a living mammal, said system comprising: a vial defining an interior which is substantially symmetrical about a vertical axis and including a bottom wall and a sidewall defining said interior, said vial further having an open mouth at the top of the vial, said bottom wall having a surface having a depression for receiving a supply of said microspheres, said sidewall having a substantially smooth inner surface; a supply of microspheres containing a radioactive isotope disposed in said depression; a septum closing the mouth of said vial; a supply of liquid; an inlet needle passing though said septum, directed at said supply of micropsheres and having a distal end terminating adjacent said bottom wall surface; a pump and associated tubing interconnecting said liquid supply and said inlet needle; an outlet needle passing through said septum and having a distal end terminating in said interior above said supply of microspheres; whereby upon connection of the outlet needle to a living body, operation of said pump causes a jet of said liquid to be directed at said supply of microspheres causing sufficient agitation to entrain said microspheres in the quantity of liquid in said interior and furthermore to force microspheres entrained in said liquid through said outlet needle.
Claim 4
Independent Claim
234 words
A system for delivering an amount of glass microspheres containing a radioactive isotope entrained in a liquid having a lower density than said microspheres into the body of a living mammal, said system comprising: a vial defining an interior which is substantially symmetrical about a vertical axis and including a bottom wall and a sidewall defining said interior, said vial further having an open mouth at the top of the vial, said bottom wall having a surface having a depression for receiving a supply of said microspheres, said sidewall having a substantially smooth inner surface; a supply of microspheres containing a radioactive isotope disposed in said depression; a septum closing the mouth of said vial; a supply of liquid; an inlet needle passing though said septum, directed at said supply of micropsheres and having a distal end terminating adjacent said bottom wall surface; a pump and associated tubing interconnecting said liquid supply and said inlet needle; an outlet needle passing through said septum and having a distal end terminating in said interior above said supply of microspheres; whereby upon connection of the outlet needle to a living body, operation of said pump causes a jet of said liquid to be directed at said supply of microspheres causing sufficient agitation to entrain said microspheres in the quantity of liquid in said interior and furthermore to force microspheres entrained in said liquid through said outlet needle.
Claim 5
Dependent Claim
35 words
A system as set forth in claim 2 wherein said inlet needle extends substantially along the axis of said interior and the distal end of said inlet needle is disposed in said supply of microspheres.
Claim 6
Dependent Claim
18 words
A system as set forth in claim 2 wherein said supply of microspheres is disposed below said sidewall.
Claim 7
Dependent Claim
24 words
A system as set forth in claim 2 wherein said distal end of said outlet needle is disposed adjacent the axis of said interior.
Claim 8
Dependent Claim
23 words
A system as set forth in claim 2 wherein said supply of microspheres occupies less than 1/10th of the volume of said interior.
Claim 9
Dependent Claim
21 words
A system as set forth in claim 2 wherein said microspheres each have a density of about 3 g/cm 3 .
Claim 10
Dependent Claim
14 words
A system as set forth in claim 2 wherein said liquid is isotonic saline.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-24 | 1991-11-23 | 1992-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-24 | 1995-11-23 | 1996-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-24 | 1999-11-23 | 2000-05-24 | $7700.00 | Window Closed / Lapsed |