US5866415A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Materials for healing cartilage and bone defects
Assignee: Individual
•
Filing: 1997-03-25
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Granted: 1999-02-02
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Expires: 2017-03-25
Abstract
Abstract The invention concerns methods for the production of in vitro constituted biological materials and their subsequent use as implants for healing cartilage and bone defects. A biological composite (28) comprising periosteum (22) and cartilage or bone forming cells (26) is described as well as an in vitro cultured periosteum.
Inventors
- 👤 Peter E. Villeneuve
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 21:08
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3804; A61L27/3821; A61L27/3604; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3654; A61L27/3683; A61L27/3695; A61L27/3817; A61L27/3839; A61L27/3843; A61L27/3847; A61L27/3852; C; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0652; C12N5/0654; C12N5/0655; A61K; A61K35/00; A61K35/12
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
40 words
A biological material for the treatment of cartilage or bone defects, comprising periosteum of sufficient size to accommodate the defect, and cartilage or bone forming cells, wherein the cartilage or bone forming cells are attached to the periosteum in vitro.
Claim 2
Dependent Claim
40 words
A biological material for the treatment of cartilage or bone defects, comprising periosteum of sufficient size to accommodate the defect, and cartilage or bone forming cells, wherein the cartilage or bone forming cells are attached to the periosteum in vitro.
Claim 3
Dependent Claim
21 words
The biological material of claim 1 wherein the cells or periosteum are isolated from tissue from a patient to be treated.
Claim 4
Independent Claim
50 words
A method for the treatment of cartilage or bone defects comprising implanting at the site to be treated a biological material comprising periosteum of sufficient size to accommodate the defect and cartilage or bone forming cells, wherein the cartilage or bone forming cells are attached to the periosteum in vitro.
Claim 5
Independent Claim
50 words
A method for the treatment of cartilage or bone defects comprising implanting at the site to be treated a biological material comprising periosteum of sufficient size to accommodate the defect and cartilage or bone forming cells, wherein the cartilage or bone forming cells are attached to the periosteum in vitro.
Claim 6
Dependent Claim
16 words
The method of claim 3 wherein the biological material is cultured in vitro prior to implantation.
Claim 7
Dependent Claim
22 words
The method of claim 3 wherein the biological materials is implanted to repair cartilage or bone damaged by inflamation, trauma or aging.
Claim 8
Independent Claim
57 words
A method of producing a biological material comprising periosteum and cartilage or bone forming cells, wherein the method comprises isolating and attaching the cartilage or bone forming cells on periosteum in growth media to produce a bilayer composite characterized by a layer of periosteum and a layer of cartilage or bone forming cells attached to the periosteum.
Claim 9
Independent Claim
57 words
A method of producing a biological material comprising periosteum and cartilage or bone forming cells, wherein the method comprises isolating and attaching the cartilage or bone forming cells on periosteum in growth media to produce a bilayer composite characterized by a layer of periosteum and a layer of cartilage or bone forming cells attached to the periosteum.
Claim 10
Dependent Claim
22 words
The method of claim 6 wherein said cartilage and bone forming cells are isolated from tissue of a patient to be treated.
Claim 11
Dependent Claim
41 words
The biological material of claim 1 produced by isolating and attaching cartilage or bone forming cells on periosteum in growth media to produce a bilayer composite characterized by a layer of periosteum and a layer of cartilage or bone forming cells.
Claim 12
Dependent Claim
45 words
The method of claim 3 wherein the biological material is produced by isolating and attaching cartilage or bone forming cells on periosteum in growth media to produce a bilayer composite characterized by a layer of periosteum and a layer of cartilage or bone forming cells.
Claim 13
Dependent Claim
14 words
The biological material of claim 1 wherein the biological material is cultured in vitro.
Claim 14
Dependent Claim
36 words
The biological material claim 1 wherein the biological material is shaped for the repair of cartilage or bone damaged by inflammation, trauma or aging, or for the repair of cartilage or bone which is congenitally defective.
Claim 15
Dependent Claim
24 words
The method of claim 6 further comprising culturing the isolated periosteum in growth media to produce a biological material containing in vitro expanded cells.
Claim 16
Dependent Claim
21 words
The method of claim 12 wherein the cells or periosteum is isolated from the tissue of a patient to be treated.
Claim 17
Dependent Claim
28 words
The biological material of claim 10 wherein the method further comprises culturing the isolated periosteum in growth media to produce a biological material containing in vitro expanded cells.
Claim 18
Dependent Claim
12 words
The biological material of claim 1 containing in vitro expanded periosteal cells.
Claim 19
Dependent Claim
21 words
The method of claim 3 wherein the biological material is implanted to repair of cartilage or bone which is congenitally defective.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-01 | 2002-08-03 | 2003-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-01 | 2006-08-03 | 2007-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-01 | 2010-08-03 | 2011-02-02 | $7700.00 | Window Closed / Lapsed |