Patent US5800545A successfully refreshed from Google Patents.
US5800545A
Expired / Lapsed
US
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Artificial hair for implantation and process for producing the same
Assignee: Individual
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Filing: 1996-06-04
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Granted: 1998-09-01
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Expires: 2016-06-04
Abstract
Abstract An artificial hair having a physiologically active surface which is formed by a such manner that protein (collagen) molecules are bonded chemically to the graft-polymerized chains introduced onto the surface of the artificial hair. When the artificial hair is implanted into a human body skin, the collagen layer 11 fixed to the surface of the artificial hair having a root part 12 is integrally assimilated and bonded to collagens in the epidermis 4, the corium layer 5, the subcutaneous tissue 6 and the galea 7, whereby the artificial hair can be firmly fixed. Thus, this artificial hair exhibits a low infection rate, a high success rate and cannot be accompanied by down-growth phenomenon.
Inventors
- 👤 Shiro Yamada
- 👤 Yoshito Ikada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:48
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/10; A61L; A61L27/00; A61L27/28; A61L27/34; A61L2430/00; A61L2430/18
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
130 words
A process for producing an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber, said process comprising the steps of: introducing a graft-polymerized polymer chain onto a surface of the artificial hair by applying ionizing radiation or ultraviolet rays which produce free radicals in the surface of the artificial hair under a condition in which the artificial hair has been immersed in a solution of a radical-polymerizable monomer selected from the group consisting of a carboxyl group-containing monomer and a sulfonic group-containing monomer; chemically bonding protein molecules to said graft-polymerized chain; and bonding the protein molecules chemically bonded to said graft-polymerized chain to one another, or to additionally added protein molecules by cross-linking to form a biologically compatible layer on the surface of the artificial hair.
Claim 2
Dependent Claim
130 words
A process for producing an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber, said process comprising the steps of: introducing a graft-polymerized polymer chain onto a surface of the artificial hair by applying ionizing radiation or ultraviolet rays which produce free radicals in the surface of the artificial hair under a condition in which the artificial hair has been immersed in a solution of a radical-polymerizable monomer selected from the group consisting of a carboxyl group-containing monomer and a sulfonic group-containing monomer; chemically bonding protein molecules to said graft-polymerized chain; and bonding the protein molecules chemically bonded to said graft-polymerized chain to one another, or to additionally added protein molecules by cross-linking to form a biologically compatible layer on the surface of the artificial hair.
Claim 3
Dependent Claim
84 words
A process for producing an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber, said process comprising the steps of introducing graft-polymerized polymer change onto a surface of the artificial hair in the presence of a deoxygenating agent; chemically bonding protein molecules to said graft-polymerized chain; and bonding the protein molecules chemically bonded to said graft-polymerized chain to one another, onto additionally added protein molecules by cross-linking to form a biologically compatible layer on the surface of the artificial hair.
Claim 4
Dependent Claim
84 words
A process for producing an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber, said process comprising the steps of introducing graft-polymerized polymer change onto a surface of the artificial hair in the presence of a deoxygenating agent; chemically bonding protein molecules to said graft-polymerized chain; and bonding the protein molecules chemically bonded to said graft-polymerized chain to one another, onto additionally added protein molecules by cross-linking to form a biologically compatible layer on the surface of the artificial hair.
Claim 5
Dependent Claim
84 words
A process for producing an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber, said process comprising the steps of introducing a graft-polymerized polymer chain onto a surface of the artificial hair; chemically bonding protein molecules to said graft-polymerized chain by utilizing an ionic bonding reaction; and bonding the protein molecules chemically bonded to said graft-polymerized chain to one another, onto additionally added protein molecules by cross-linking to form a biologically compatible layer on the surface of the artificial hair.
Claim 6
Dependent Claim
84 words
A process for producing an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber, said process comprising the steps of introducing a graft-polymerized polymer chain onto a surface of the artificial hair; chemically bonding protein molecules to said graft-polymerized chain by utilizing an ionic bonding reaction; and bonding the protein molecules chemically bonded to said graft-polymerized chain to one another, onto additionally added protein molecules by cross-linking to form a biologically compatible layer on the surface of the artificial hair.
Claim 7
Dependent Claim
59 words
In an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber and having a loop (12) and a hook (13) at one end thereof, the improvement wherein said artificial hair includes a biologically compatible layer on an outer surface thereof, said biologically compatible layer comprising a protein fixed to said synthetic polymer by chemical bonding.
Claim 8
Dependent Claim
59 words
In an artificial hair for implantation, formed from a monofilament of a synthetic polymer fiber and having a loop (12) and a hook (13) at one end thereof, the improvement wherein said artificial hair includes a biologically compatible layer on an outer surface thereof, said biologically compatible layer comprising a protein fixed to said synthetic polymer by chemical bonding.
Claim 9
Dependent Claim
29 words
A process for producing an artificial hair for implantation according to claim 1, wherein the protein is chemically bonded to said graft-polymerized chain by utilizing a covalent bonding reaction.
Claim 10
Dependent Claim
29 words
A process for producing an artificial hair for implantation according to claim 5, wherein said covalent bonding reaction is promoted by activating said graft-polymerized chain by an activating agent.
Claim 11
Dependent Claim
16 words
A process according to claim 6, wherein said activating agent is a carbodiimide compound or N-hydroxyl-succinimide.
Claim 12
Dependent Claim
23 words
A process for producing an artificial hair for implantation according to claim 2, wherein said deoxygenating agent used is riboflavin or periodic acid.
Claim 13
Dependent Claim
40 words
A process for producing an artificial hair for implantation according to claim 1, wherein said carboxyl group-containing monomer used is one or more monomers selected from the group consisting of acrylic and methacrylic acids and the salts and derivatives thereof.
Claim 14
Dependent Claim
44 words
A process for producing an artificial hair for implantation according to claim 1, wherein said sulfonic group-containing monomer used is one or more monomers selected from the group consisting of acrylamidemethyl propane sulfonic acid and styrene sulfonic acid and the salts and derivatives thereof.
Claim 15
Dependent Claim
49 words
A process for producing an artificial hair for implantation according to claim 3, wherein the pH value of a solution resulting from the reaction between said graft-polymerized chain and said protein is adjusted to a value in a range of 2 to 7 to promote said ionic bonding reaction.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-08-31 | 2002-03-02 | 2002-09-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-08-31 | 2006-03-02 | 2006-09-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-08-31 | 2010-03-02 | 2010-09-01 | $7700.00 | Window Closed / Lapsed |