US5376400A
Expired / Lapsed
US
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Combined plasma and gamma radiation polymerization method for modifying surfaces
Assignee: University of Florida Research Foundation Inc
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Filing: 1993-01-13
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Granted: 1994-12-27
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Expires: 2013-01-13
Abstract
Abstract A method for modifying the surface of a material by: a. exposing the surface to a glow discharge plasma to activate the surface; b. exposing the surface to an ethylenically unsaturated monomer or mixture of monomers; and c. irradiating the activated surface with gamma radiation or electron beam radiation in the presence of the ethylenically unsaturated monomer to form a graft polymerized coating thereon.
Inventors
- 👤 Eugene P. Goldberg
- 👤 Ali Yahiaoui
- 👤 James Burns
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:35
CPC Classifications
C; C08; C08J; C08J7/00; C08J7/12; C08J7/123; A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L29/00; A61L29/08; A61L29/085; B; B05; B05D; B05D1/00; B05D1/60; B05D3/00; B05D3/06; B05D3/068; B05D3/14; B05D3/141; B05D3/142; B05D3/144; C03; C03C; C03C17/00; C03C17/28; C03C17/32; C03C23/00; C03C23/0005; C03C23/0035; C03C23/004; C03C23/006; C04; C04B; C04B41/00; C04B41/009; C04B41/45; C04B41/46; C04B41/48; C04B41/80; C04B41/81; C04B41/82; C04B41/83; C23; C23C; C23C26/00; C23C8/00; C23C8/06; C23C8/36; A61L2400/00; A61L2400/18; C03C2218/00; C03C2218/30; C03C2218/31; C04B2111/00; C04B2111/00474; C04B2111/00836
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
240 words
A method for modifying a surface of a hydrophobic material by a gamma-irradiation or electron beam irradiation induced polymerization thereon of one or a mixture of ethylenically unsaturated monomers so as to form a hydrophilic polymeric coating on said surface, the improvement comprising the steps of: a) exposing said surface to a glow discharge plasma (GDP) having a power from about 1 to about 500 W and for a time sufficient to induce grafting sites on said surface for the surface graft polymerization of steps b and c; b) exposing said surface to a solution of an ethylenically unsaturated monomer or mixture thereof capable, via said ethylenic unsaturation, of gamma-irradiation or electron beam induced polymerization; and c) irradiating said activated surface with gamma or electron beam radiation in the presence of said ethylenic unsaturated monomer or mixture thereof to thereby form a hydrophilic polymeric surface coating on said surface, said polymerization being initiated by said gamma or electron beam radiation wherein said polymerization is conducted under the following conditions: i) monomer concentration in said solution in the range of from about 0.1% to about 50%, by weight; ii) total gamma or electron beam dose in the range of from about 0.001 to less than about 0.50 Mrad; and iii) gamma dose rate in the range of from about 10 to about 2500 rads/min, or electron beam dose rate in the range of from about 10 to about 10 8 rads/min.
Claim 2
Independent Claim
240 words
A method for modifying a surface of a hydrophobic material by a gamma-irradiation or electron beam irradiation induced polymerization thereon of one or a mixture of ethylenically unsaturated monomers so as to form a hydrophilic polymeric coating on said surface, the improvement comprising the steps of: a) exposing said surface to a glow discharge plasma (GDP) having a power from about 1 to about 500 W and for a time sufficient to induce grafting sites on said surface for the surface graft polymerization of steps b and c; b) exposing said surface to a solution of an ethylenically unsaturated monomer or mixture thereof capable, via said ethylenic unsaturation, of gamma-irradiation or electron beam induced polymerization; and c) irradiating said activated surface with gamma or electron beam radiation in the presence of said ethylenic unsaturated monomer or mixture thereof to thereby form a hydrophilic polymeric surface coating on said surface, said polymerization being initiated by said gamma or electron beam radiation wherein said polymerization is conducted under the following conditions: i) monomer concentration in said solution in the range of from about 0.1% to about 50%, by weight; ii) total gamma or electron beam dose in the range of from about 0.001 to less than about 0.50 Mrad; and iii) gamma dose rate in the range of from about 10 to about 2500 rads/min, or electron beam dose rate in the range of from about 10 to about 10 8 rads/min.
Claim 3
Dependent Claim
15 words
The method of claim 1, wherein said material is metallic, polymeric, ceramic, glass or quartz.
Claim 4
Dependent Claim
28 words
The method of claim 2, wherein said material is polymethylmethacrylate, polypropylene, polyvinylidene fluoride, polydimethylsiloxane, a polycarbonate, a polycarbonate/polydimethylsiloxane copolymer, polyethylene, polyvinylchloride, polytetrafluoroethylene, polyperfluoroethylenepropylene copolymers, polyurethanes, or polyurethane/polydimethylsiloxane copolymers.
Claim 5
Dependent Claim
21 words
The method of claim 2, wherein said material is iron, stainless steel, tantalum, titanium, aluminum, copper or chromium, or alloys thereof.
Claim 6
Dependent Claim
12 words
The method of claim 1, wherein said material is a biomedical article.
Claim 7
Dependent Claim
16 words
The method of claim 5, wherein said bio-medical article is a prosthetic implant or surgical instrument.
Claim 8
Dependent Claim
14 words
The method of claim 1, wherein said GDP is RF-, microwave- or DC discharge-generated.
Claim 9
Dependent Claim
27 words
The method of claim 1, wherein said surface is exposed to RF-GDP for a time in the range of from about 0.1 sec. to about 120 min.
Claim 10
Dependent Claim
23 words
The method of claim 1, wherein said GDP treated surface is exposed to air, water vapor or oxygen before said gamma-irradiation induced polymerization.
Claim 11
Dependent Claim
67 words
The method of claim 1, wherein said GDP treated surface is pre-soaked in one or more of said ethylenically unsaturated monomers or in a first aqueous solution of one or more monomers, having a concentration of monomer therein of from 5 to about 95% by weight, and conducting said gamma-irradiation or electron beam induced polymerization in a second aqueous solution of one or more of said monomers.
Claim 12
Dependent Claim
31 words
The method of claim 1, wherein said monomer is N-vinylpyrrolidone, hydroxyethylmethacrylate, acrylamide, dimethylacrylamide, diemthylaminoethylmethacrylate, acrylic acid, methacrylic acid, a vinyl substituted polyethylene or polypropylene glycol, a vinylpyridine, or a vinylsulfonic acid.
Claim 13
Dependent Claim
43 words
The method of claim 1, wherein said monomer or mixture of monomers is gamma-irradiation induced copolymerized with an ionic monomer or mixture thereof, the total monomer concentration in said solution being in the range of from about 0.1% to about 50%, by weight.
Claim 14
Dependent Claim
17 words
The method of claim 12, wherein said ionic monomer is a vinylsulfonic acid or a vinylcarboxylic acid.
Claim 15
Dependent Claim
18 words
The method of claim 13, wherein said vinylsulfonic acid is styrene sulfonic acid, vinylsulfonic acid, or a sulfoalkylacrylate.
Claim 16
Dependent Claim
15 words
The method of claim 13, wherein said vinyl-carboxylic acid is acrylic, methacrylic or crotonic acid.
Claim 17
Dependent Claim
13 words
The method of claim 12, wherein said ionic monomer is an amino-functional monomer.
Claim 18
Dependent Claim
19 words
The method of claim 16, wherein said amino-functional monomer is a vinylpyridine, an aminostyrene, an aminoacrylate or an aminomethacrylate.
Claim 19
Dependent Claim
22 words
The method of claim 1, wherein said monomer or mixture of monomers is gamma-irradiation induced polymerized in the substantial absence of oxygen.
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