Patent US5776900A successfully refreshed from Google Patents.
US5776900A
Expired / Lapsed
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Hemoregulatory peptides
Assignee: SmithKline Beecham Corp
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Filing: 1995-05-30
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Granted: 1998-07-07
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Expires: 2015-05-30
Abstract
Abstract The invention provides compounds of the general formula: <IMAGE> The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
Inventors
- 👤 Pradip Kumar Bhatnagar
- 👤 William Francis Huffman
- 👤 James Edward Talmadge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:11
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; C07K7/067; C07K7/02; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
131 words
A method of preventing viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of Formula (I): ##STR7## wherein: m is 1, 2 or 4; A is pyroglutamic acid, proline, glutamine, glutamic acid, picolinic acid, pipecolinic acid, pyrrole carboxylic acid, isopyrrole carboxylic acid, pyrazole carboxylic acid, isoimidazole carboxylic acid, triazole carboxylic acid, pyrimidine carboxylic acid, pyridine carboxylic acid, pyridazine carboxylic acid, pyrazine carboxylic acid, piperazine carboxylic acid, triazine carboxylic acid or morpholine carboxylic acid; B is serine, theronine, glutamic acid, or aspartic acid; C is glutamic acid or aspartic acid; D is lysine or the carboxyamide derivative thereof; E is glutamic acid, aspartic acid or a peptide bond; F is tyrosine or a peptide bond; or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
131 words
A method of preventing viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of Formula (I): ##STR7## wherein: m is 1, 2 or 4; A is pyroglutamic acid, proline, glutamine, glutamic acid, picolinic acid, pipecolinic acid, pyrrole carboxylic acid, isopyrrole carboxylic acid, pyrazole carboxylic acid, isoimidazole carboxylic acid, triazole carboxylic acid, pyrimidine carboxylic acid, pyridine carboxylic acid, pyridazine carboxylic acid, pyrazine carboxylic acid, piperazine carboxylic acid, triazine carboxylic acid or morpholine carboxylic acid; B is serine, theronine, glutamic acid, or aspartic acid; C is glutamic acid or aspartic acid; D is lysine or the carboxyamide derivative thereof; E is glutamic acid, aspartic acid or a peptide bond; F is tyrosine or a peptide bond; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
37 words
A method of preventing viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of claim 1 which is (pglu-Glu-Asp) 2 -Sub-(Lys) 2 SEQ ID NO: 1!.
Claim 4
Dependent Claim
126 words
A method of preventing viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of claim 1 chosen from the group consisting of: (pGlu-Glu-Asp) 2 Adp(Lys) 2 SEQ ID NO: 2! (pGlu-Glu-Glu) 2 Sub(Lys) 2 SEQ ID NO: 3! (pGlu-Asp-Asp) 2 Sub(Lys) 2 SEQ ID NO: 4! (Pic-Glu-Asp) 2 Sub(Lys) 2 SEQ ID NO: 5! (L-Ppc-Glu-Asp) 2 Sub(Lys) 2 SEQ ID NO: 6! (pGlu-Ser-Asp) 2 Sub(Lys) 2 SEQ ID NO: 7! (pGlu-Ser-Asp) 2 Adp(Lys) 2 SEQ ID NO: 8! (pGlu-Ser-Asp) 2 Adp(Lys-NH 2 ) 2 SEQ ID NO: 29! (Pic-Ser-Asp) 2 Adp(Lys) 2 SEQ ID NO: 9! (Pic-Ser-Asp) 2 Adp(Lys-NH 2 ) 2 SEQ ID NO: 30! or (pGlu-Glu-Asp) 2 -Adp(Tyr-Lys) 2 SEQ ID NO: 10!.
Claim 5
Dependent Claim
26 words
A method of preventing Candida or Herpes infection which comprises administering to a subject in need thereof, an effective amount of a compound of claim 1.
Claim 6
Dependent Claim
36 words
A method of preventing Candida or Herpes infection which comprises administering to a subject in need thereof, an effective amount of a compound of claim 1 which is (pglu-Glu-Asp) 2 -Sub-(Lys 2 SEQ ID NO: 1!.
Claim 7
Independent Claim
131 words
A method of treating viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of Formula (I): ##STR8## wherein: m is 1, 2 or 4; A is pyroglutamic acid, proline, glutamine, glutamic acid, picolinic acid, pipecolinic acid, pyrrole carboxylic acid, isopyrrole carboxylic acid, pyrazole carboxylic acid, isoimidazole carboxylic acid, triazole carboxylic acid, pyrimidine carboxylic acid, pyridine carboxylic acid, pyridazine carboxylic acid, pyrazine carboxylic acid, piperazine carboxylic acid, triazine carboxylic acid or morpholine carboxylic acid; B is serine, theronine, glutamic acid, or aspartic acid; C is glutamic acid or aspartic acid; D is lysine or the carboxyamide derivative thereof; E is glutamic acid, aspartic acid or a peptide bond; F is tyrosine or a peptide bond; or a pharmaceutically acceptable salt thereof.
Claim 8
Independent Claim
131 words
A method of treating viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of Formula (I): ##STR8## wherein: m is 1, 2 or 4; A is pyroglutamic acid, proline, glutamine, glutamic acid, picolinic acid, pipecolinic acid, pyrrole carboxylic acid, isopyrrole carboxylic acid, pyrazole carboxylic acid, isoimidazole carboxylic acid, triazole carboxylic acid, pyrimidine carboxylic acid, pyridine carboxylic acid, pyridazine carboxylic acid, pyrazine carboxylic acid, piperazine carboxylic acid, triazine carboxylic acid or morpholine carboxylic acid; B is serine, theronine, glutamic acid, or aspartic acid; C is glutamic acid or aspartic acid; D is lysine or the carboxyamide derivative thereof; E is glutamic acid, aspartic acid or a peptide bond; F is tyrosine or a peptide bond; or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
37 words
A method of treating viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of claim 6 which is (pglu-Glu-Asp) 2 -Sub-(Lys) 2 SEQ ID NO: 1!.
Claim 10
Dependent Claim
126 words
A method of treating viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of claim 6 chosen from the group consisting of: (pGlu-Glu-Asp) 2 Adp(Lys) 2 SEQ ID NO: 2! (pGlu-Glu-Glu) 2 Sub(Lys) 2 SEQ ID NO: 3! (pGlu-Asp-Asp) 2 Sub(Lys) 2 SEQ ID NO: 4! (Pic-Glu-Asp) 2 Sub(Lys) 2 SEQ ID NO: 5! (L-Ppc-Glu-Asp) 2 Sub(Lys) 2 SEQ ID NO: 6! (pGlu-Ser-Asp) 2 Sub(Lys) 2 SEQ ID NO: 7! (pGlu-Ser-Asp) 2 Adp(Lys) 2 SEQ ID NO: 8! (pGlu-Ser-Asp) 2 Adp(Lys-NH 2 ) 2 SEQ ID NO: 29! (Pic-Ser-Asp) 2 Adp(Lys) 2 SEQ ID NO: 9! (Pic-Ser-Asp) 2 Adp(Lys-NH 2 ) 2 SEQ ID NO: 30! or (pGlu-Glu-Asp) 2 -Adp(Tyr-Lys) 2 SEQ ID NO: 10!.
Claim 11
Dependent Claim
26 words
A method of treating Candida or Herpes infection which comprises administering to a subject in need thereof, an effective amount of a compound of claim 6.
Claim 12
Dependent Claim
36 words
A method of treating Candida or Herpes infection which comprises administering to a subject in need thereof, an effective amount of a compound of claim 6 which is (pglu-Glu-Asp) 2 -Sub-(Lys) 2 SEQ ID NO: 1!.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-07-06 | 2002-01-05 | 2002-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-07-06 | 2006-01-05 | 2006-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-07-06 | 2010-01-05 | 2010-07-07 | $7700.00 | Window Closed / Lapsed |