US5762065A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of magnetic resonance arteriography using contrast agents
Assignee: Individual
•
Filing: 1996-08-30
•
Granted: 1998-06-09
•
Expires: 2016-08-30
Abstract
Abstract The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.
Inventors
- 👤 Martin R. Prince
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:42
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/41; A61B5/414; A61B5/416; A61B5/411; A61K; A61K49/00; A61K49/06; A61K49/18; G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; G01R33/563; A61B5/20; A61B5/201; A61B5/72; A61B5/7271; A61B5/7285; G01R33/28; G01R33/281; G01R33/561; G01R33/5619; G01R33/56308
Claims Analysis
Total Claims: 48
Claim 1
Independent Claim
80 words
A method of imaging a portion of an artery in a patient using magnetic resonance imaging, comprising, collecting a first image data set; administering a magnetic resonance contrast agent to the patient; and collecting a second image data set including collecting image data which is representative of a substantial portion of a center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of contrast agent in adjacent veins and background tissue.
Claim 2
Independent Claim
80 words
A method of imaging a portion of an artery in a patient using magnetic resonance imaging, comprising, collecting a first image data set; administering a magnetic resonance contrast agent to the patient; and collecting a second image data set including collecting image data which is representative of a substantial portion of a center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of contrast agent in adjacent veins and background tissue.
Claim 3
Dependent Claim
45 words
The method of claim 1 wherein the steps of collecting the first and second image data sets include using 3D gradient echo pulse sequences and the step of administering the magnetic resonance contrast agent includes administering the contrast agent to the patient by bolus injection.
Claim 4
Dependent Claim
24 words
The method of claim 2 wherein at least one of the 3D gradient echo pulse sequences is a 3D spoiled gradient echo pulse sequence.
Claim 5
Dependent Claim
27 words
The method of claim 1 wherein the step of collecting first image data set includes collecting data before administering a magnetic resonance contrast agent to the patient.
Claim 6
Dependent Claim
44 words
The method of claim 1 wherein the step of collecting the second image data set further includes collecting image data which is representative of the center of k-space while a flip angle is between about 20° to about 90°, TR≦25 milliseconds and TE≦7 milliseconds.
Claim 7
Dependent Claim
44 words
The method of claim 1 further including constructing an image of the artery by subtracting at least two images selected from a set of images comprising the images produced by the first image data set and images produced by the second image data set.
Claim 8
Dependent Claim
46 words
The method of claim 6 wherein the step of collecting the second image data set further includes collecting at least 25% of the image data which is representative of the center of k-space while the concentration of contrast agent in the artery is substantially a maximum.
Claim 9
Dependent Claim
45 words
The method of claim 6 wherein the step of collecting the second image data set further includes collecting image data which is representative of a substantial portion of the center of k-space while the concentration of contrast agent in the artery is substantially a maximum.
Claim 10
Dependent Claim
35 words
The method of claim 6 wherein the step of administering the magnetic resonance contrast agent to the patient further includes administering the contrast agent to the patient substantially throughout collecting the second image data set.
Claim 11
Dependent Claim
46 words
The method of claim 1 wherein the step of collecting the second image data set further includes collecting a portion of the image data which is representative of a center of k-space while the concentration of the contrast agent in the artery is substantially a maximum.
Claim 12
Independent Claim
96 words
A method of imaging a portion of an artery in a patient using magnetic resonance imaging, the method comprising, collecting a first image data set before administering a substantial amount of a magnetic resonance contrast agent; administering a magnetic resonance contrast agent to the patient; and collecting a second image data set including collecting image data which is representative of at least a portion of a center of k-space while a concentration of the contrast agent in the artery is about a maximum relative to a concentration of contrast agent in adjacent veins and background tissue.
Claim 13
Independent Claim
96 words
A method of imaging a portion of an artery in a patient using magnetic resonance imaging, the method comprising, collecting a first image data set before administering a substantial amount of a magnetic resonance contrast agent; administering a magnetic resonance contrast agent to the patient; and collecting a second image data set including collecting image data which is representative of at least a portion of a center of k-space while a concentration of the contrast agent in the artery is about a maximum relative to a concentration of contrast agent in adjacent veins and background tissue.
Claim 14
Dependent Claim
29 words
The method of claim 11 wherein the step of administering a magnetic resonance contrast agent to the patient includes administering the contrast agent to the patient by bolus injection.
Claim 15
Dependent Claim
57 words
The method of claim 11 wherein the step of collecting the second image data set further includes collecting a substantial portion of the image data which is representative of the center of k-space while the concentration of contrast agent in the artery is substantially higher than a concentration of contrast agent in adjacent veins and background tissue.
Claim 16
Dependent Claim
25 words
The method of claim 11 wherein the steps of collecting the first and second image data sets further include using 3D gradient echo pulse sequences.
Claim 17
Dependent Claim
23 words
The method of claim 14 wherein at least one of 3D gradient echo pulse sequences is a 3D spoiled gradient echo pulse sequence.
Claim 18
Dependent Claim
42 words
The method of claim 11 wherein the step of collecting the second image data set further includes collecting a substantial portion of the center of k-space while a flip angle is between about 20° to about 90°, TR≦30 milliseconds and TE≦7 milliseconds.
Claim 19
Dependent Claim
60 words
The method of claim 11 wherein the step of collecting the second image data set further includes collecting the image data which is representative of the center of k-space during administration of the contrast agent and while the concentration of contrast agent in the artery is substantially higher than a concentration of contrast agent in adjacent veins and background tissue.
Claim 20
Dependent Claim
51 words
The method of claim 11 wherein the step of collecting the second image data set further includes collecting substantially all of the center of k-space while the concentration of the contrast agent in the artery is substantially greater than a concentration of the contrast agent in veins adjacent to the artery.
Claim 21
Dependent Claim
19 words
The method of claim 11 further includes constructing an image of the artery using the second image data set.
Claim 22
Dependent Claim
44 words
The method of claim 19 further includes constructing an image of the artery by subtracting at least two images selected from a set of images comprising the images produced by the first image data set and images produced by the second image data set.
Claim 23
Independent Claim
141 words
A method of imaging a portion of an artery in a patient using magnetic resonance imaging, the portion of the artery being within a region of interest, the method comprising, collecting a first image data set administering a magnetic resonance contrast agent to the patient; and collecting a second image data set including: collecting image data which is representative of at least a portion of a center of k-space while a concentration of the contrast agent in the artery is about a maximum relative to a concentration of contrast agent in adjacent veins and background tissue; and collecting image data which is representative of a substantial portion of the center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in veins and background tissue adjacent to the artery.
Claim 24
Independent Claim
141 words
A method of imaging a portion of an artery in a patient using magnetic resonance imaging, the portion of the artery being within a region of interest, the method comprising, collecting a first image data set administering a magnetic resonance contrast agent to the patient; and collecting a second image data set including: collecting image data which is representative of at least a portion of a center of k-space while a concentration of the contrast agent in the artery is about a maximum relative to a concentration of contrast agent in adjacent veins and background tissue; and collecting image data which is representative of a substantial portion of the center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in veins and background tissue adjacent to the artery.
Claim 25
Dependent Claim
47 words
The method of claim 21 wherein the step of administering a magnetic resonance contrast agent to the patient includes administering the contrast agent to the patient by bolus injection and the step of collecting the second image data set includes using a 3D gradient echo pulse sequence.
Claim 26
Dependent Claim
24 words
The method of claim 22 wherein at least one of the 3D gradient echo pulse sequences is a 3D spoiled gradient echo pulse sequence.
Claim 27
Dependent Claim
44 words
The method of claim 21 further includes constructing an image of the artery by subtracting at least two images selected from a set of images comprising the images produced by the first image data set and images produced by the second image data set.
Claim 28
Dependent Claim
74 words
The method of claim 21 wherein the step of collecting the second image data set further includes collecting a substantial portion of the image data which is representative of the center of k-space while the concentration of contrast agent in the artery is substantially higher than a concentration of contrast agent in adjacent veins and background tissue and while a flip angle is between about 20° to about 90°, TR≦30 milliseconds and TE≦7 milliseconds.
Claim 29
Dependent Claim
37 words
The method of claim 21 wherein the step of collecting image data which is representative of the substantial portion of the center of k-space includes collecting image data while a slice thickness is less than 5 millimeters.
Claim 30
Dependent Claim
34 words
The method of claim 21 wherein the step of collecting image data which is representative of the substantial portion of the center of k-space includes collecting image data using a coronally oriented imaging volume.
Claim 31
Dependent Claim
34 words
The method of claim 21 further including constructing an image of the artery by subtracting the image data of the first image data set from the image data of the second image data set.
Claim 32
Dependent Claim
34 words
The method of claim 21 further including constructing an image of the artery by subtracting the image data of the second image data set from the image data of the first image data set.
Claim 33
Dependent Claim
46 words
The method of claim 21 wherein the step of collecting image data which is representative of the substantial portion of the center of k-space includes collecting image data using a coronally oriented imaging volume and wherein a field of view is greater than about 30 centimeters.
Claim 34
Independent Claim
91 words
A method of imaging an artery in a patient using magnetic resonance imaging, comprising, collecting a first image data set; administering a magnetic resonance contrast agent to the patient; and collecting a second image data set using a body coil, the step of collecting the second image data set includes collecting image data which is representative of a substantial portion of a center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in adjacent veins and background tissue.
Claim 35
Independent Claim
91 words
A method of imaging an artery in a patient using magnetic resonance imaging, comprising, collecting a first image data set; administering a magnetic resonance contrast agent to the patient; and collecting a second image data set using a body coil, the step of collecting the second image data set includes collecting image data which is representative of a substantial portion of a center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in adjacent veins and background tissue.
Claim 36
Dependent Claim
24 words
The method of claim 31 wherein the steps of collecting the first and second image data sets includes using 3D gradient echo pulse sequences.
Claim 37
Dependent Claim
24 words
The method of claim 31 wherein at least one of the 3D gradient echo pulse sequences is a 3D spoiled gradient echo pulse sequence.
Claim 38
Dependent Claim
39 words
The method of claim 31 wherein the step of collecting the second image data set further includes collecting a portion of the center of k-space while the concentration of the contrast agent in the artery is substantially a maximum.
Claim 39
Dependent Claim
45 words
The method of claim 31 wherein the step of collecting the second image data set further includes collecting the image data which is representative of the center of k-space while a flip angle is between about 20° to about 90°, TR≦30 milliseconds and TE≦7 milliseconds.
Claim 40
Dependent Claim
76 words
The method of claim 31 wherein the step of collecting the second image data set further includes collecting at least 50% of the image data which is representative of the center of k-space while the concentration of the contrast agent in the artery is substantially higher than the concentration of the contrast agent in veins adjacent to the artery and while a flip angle is between about 20° to about 90°, TR≦30 milliseconds and TE≦7 milliseconds.
Claim 41
Dependent Claim
50 words
The method of claim 31 wherein the step of collecting the second image data set further includes collecting image data which is representative of the substantial portion of the center of k-space during administration of the contrast agent and while a flip angle is between about 25° to about 90°.
Claim 42
Dependent Claim
19 words
The method of claim 31 further includes constructing an image of the artery using the second image data set.
Claim 43
Dependent Claim
44 words
The method of claim 31 further includes constructing an image of the artery by subtracting at least two images selected from a set of images comprising the images produced by the first image data set and images produced by the second image data set.
Claim 44
Dependent Claim
45 words
The method of claim 39 wherein the step of collecting the second image data set further includes collecting the image data which is representative of the center of k-space while a flip angle is between about 20° to about 90°, TR≦30 milliseconds and TE≦7 milliseconds.
Claim 45
Dependent Claim
33 words
The method of claim 31 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data while a slice thickness is less than 5 millimeters.
Claim 46
Dependent Claim
42 words
The method of claim 31 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data using a coronally oriented imaging volume and wherein a field of view is greater than about 30 centimeters.
Claim 47
Dependent Claim
34 words
The method of claim 31 further including constructing an image of the artery by subtracting the image data of the first image data set from the image data of the second image data set.
Claim 48
Dependent Claim
34 words
The method of claim 31 further including constructing an image of the artery by subtracting the image data of the second image data set from the image data of the first image data set.
References Cited (Backward Citations)
US4006736A
Cited
US3973554A
Cited
US4202333A
Cited
US4298000A
Cited
US4430079A
Cited
US4597754A
Cited
US4585008A
Cited
US4585941A
Cited
US5087439A
Cited
US4826673A
Cited
US4880008A
Cited
US4777957A
Cited
US5010191A
Cited
US4865043A
Cited
US4770183A
Cited
US4718424A
Cited
US4877599A
Cited
US4822594A
Cited
US4915111A
Cited
US5055288A
Cited
US5011686A
Cited
US5260050A
Cited
US5078986A
Cited
US5034694A
Cited
US5190744A
Cited
US5315997A
Cited
US5167232A
Cited
US5141740A
Cited
US5305751A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-08 | 2001-12-08 | 2002-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-08 | 2005-12-08 | 2006-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-08 | 2009-12-08 | 2010-06-09 | $7700.00 | Window Closed / Lapsed |