US5078986A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
Assignee: Mallinckrodt Inc
•
Filing: 1990-08-13
•
Granted: 1992-01-07
•
Expires: 2010-08-13
Abstract
Abstract Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a substantially nontoxic paramagnetic image altering agent comprised of a composition containing a chelate of a paramagnetic element, such as manganese, gadolinium or iron, carried by a liposome. The chelate is carried by or within the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.
Inventors
- 👤 Mark E. Bosworth
- 👤 Ronald M. Hopkins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 11:35
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; A61K49/1812; Y; Y10; Y10S; Y10S424/00; Y10S424/90; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
73 words
A method for enhancing NMR imaging of body organs and tissues which comprises administering a diagnostically effective amount of a substantially nontoxic paramagnetic image altering agent to a living animal body in a sufficient amount to provide enhancement of NMR images of said body organs and tissues, said paramagnetic image altering agent containing a chelate of a paramagnetic element and an excess of a chelating agent as a salt of said chelating agent.
Claim 2
Independent Claim
73 words
A method for enhancing NMR imaging of body organs and tissues which comprises administering a diagnostically effective amount of a substantially nontoxic paramagnetic image altering agent to a living animal body in a sufficient amount to provide enhancement of NMR images of said body organs and tissues, said paramagnetic image altering agent containing a chelate of a paramagnetic element and an excess of a chelating agent as a salt of said chelating agent.
Claim 3
Dependent Claim
19 words
A method as set forth in claim 1 wherein said paramagnetic image altering agent is carried by a liposome.
Claim 4
Dependent Claim
35 words
A method as set forth in claim 1 or claim 2 wherein said paramagnetic element is selected from the group consisting of manganese, gadolinium, cobalt, chromium, nickel, iron, and other elements of the lanthanide series.
Claim 5
Dependent Claim
38 words
A method as set forth in claim 1 or claim 2 wherein said chelating agent is selected from the group consisting of ethylenediaminetetraacetic acid, diethylenetriamine pentaacetic acid, nitriloacetic acid, trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid, 1,3-diamino-2-hydroxypropyl-N,N,N',N'-tetraacetic acid and ethyleneglycolbis (beta-aminoethyl ether)-N,N-tetraacetic acid.
Claim 6
Dependent Claim
30 words
A method as set forth in claim 1 or claim 2 wherein said salt of said chelating agent is selected from the group consisting of sodium, calcium, and mixtures thereof.
Claim 7
Dependent Claim
25 words
A method as set forth in claim 1 or clam 2 wherein said paramagnetic image altering agent contains manganous disodium ethylenediaminetetraacetate and calcium disodium ethylenediaminetetraacetate.
Claim 8
Dependent Claim
27 words
A method as set forth in claim 1 or claim 2 wherein said paramagnetic image altering agent contains gadolinium disodium diethylenetriamine pentaacetate and calcium disodium diethylenetriamine pentaacetate.
Claim 9
Dependent Claim
27 words
A method as set forth in claim 1 or claim 2 wherein said paramagnetic image altering agent contains gadolinium disodium diethylenetriamine pentaacetate and calcium trisodium diethylenetriamine pentaacetate.
Claim 10
Dependent Claim
19 words
A method as set forth in claim 1 or claim 2 wherein NMR images of the liver are enhanced.
Claim 11
Dependent Claim
19 words
A method as set forth in claim 1 or claim 2 wherein NMR images of the spleen are enhanced.
Claim 12
Dependent Claim
19 words
A method as set forth in claim 1 or claim 2 wherein NMR images of the heart are enhanced.
Claim 13
Dependent Claim
20 words
A method as set forth in claim 1 or claim 2 wherein NMR images of the glandular organs are enhanced.
Claim 14
Dependent Claim
22 words
A method as set forth in claim 1 or claim 2 wherein NMR images of the lung and lymphatic system are enhanced.
Claim 15
Dependent Claim
14 words
A method as set forth in claim 1 wherein said paramagnetic element is gadolinium.
Claim 16
Dependent Claim
14 words
A method as set forth in claim 1 wherein said paramagnetic element is manganese.
Claim 17
Dependent Claim
14 words
A method as set forth in claim 1 wherein said paramagnetic element is iron.
Claim 18
Dependent Claim
23 words
A method as set forth in claim 1 wherein said chelate of a paramagnetic element is a diethylenetriamine pentaacetic acid chelate of gadolinium.
Claim 19
Dependent Claim
22 words
A method as set forth in claim 17 wherein said salt of said chelating agent is a salt of diethylenetriamine pentaacetic acid.
Claim 20
Dependent Claim
19 words
A method as set forth in claim 1 wherein said salt of said chelating agent is a calcium salt.
References Cited (Backward Citations)
US3932657A
Cited
US4016290A
Cited
US4224179A
Cited
US4397846A
Cited
US4647447A
Cited
US4497791A
Cited
US4544545A
Cited
US4863717A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-06 | 1995-07-08 | 1996-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-06 | 1999-07-08 | 2000-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-06 | 2003-07-08 | 2004-01-07 | $7700.00 | Window Closed / Lapsed |