Patent US3672738A successfully refreshed from Google Patents.
Patent US5756536A successfully refreshed from Google Patents.
US5756536A
Expired / Lapsed
US
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Microbial transformation of taxol and cephalomannine
Assignee: Purdue Research Foundation
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Filing: 1996-10-17
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Granted: 1998-05-26
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Expires: 2016-10-17
Abstract
Abstract A biotransformation process for the production of hydroxylated derivatives of taxol and new derivatives of taxol and cephalomannine are described. A method for converting taxol to L-760,006 and L-760,007, and a method for converting cephalomanine to L-745,596 are provided.
Inventors
- 👤 Shieh-Shung Tom Chen
- 👤 Ching-Jer Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:56
CPC Classifications
C; C12; C12P; C12P17/00; C12P17/02; C07; C07D; C07D305/00; C07D305/14
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
28 words
A method of converting taxol to L- 760,006 and L-760,007 which comprises: (a) cultivating a microorganism in a medium containing taxol; and (b) recovering the L-760,006 and L-760,007.
Claim 2
Independent Claim
28 words
A method of converting taxol to L- 760,006 and L-760,007 which comprises: (a) cultivating a microorganism in a medium containing taxol; and (b) recovering the L-760,006 and L-760,007.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the microorganism is Streptomyces sp. MA 7065 (ATCC 55604).
Claim 4
Dependent Claim
11 words
A compound selected from the group consisting of L-760,006 and L-760,007.
Claim 5
Dependent Claim
11 words
A compound selected from the group consisting of L-760,006 and L-760,007.
Claim 6
Dependent Claim
9 words
A pharmaceutical composition comprising a compound of claim 3.
Claim 7
Dependent Claim
19 words
A method of treating a patient having cancer comprising administration of a compound of claim 3 to the patient.
Claim 8
Independent Claim
23 words
A method of converting cephalomanine to L-745,596, which comprises: (a) cultivating a microorganism in a medium containing cephalomanine; and (b) recovering the L-745,596.
Claim 9
Independent Claim
23 words
A method of converting cephalomanine to L-745,596, which comprises: (a) cultivating a microorganism in a medium containing cephalomanine; and (b) recovering the L-745,596.
Claim 10
Dependent Claim
15 words
The method of claim 1 wherein the microorganism is Streptomyces sp. MA 7065 (ATCC 55604).
Claim 11
Dependent Claim
2 words
Compound L-745,596.
Claim 12
Dependent Claim
2 words
Compound L-745,596.
Claim 13
Dependent Claim
6 words
A pharmaceutical composition comprising compound L-745,596.
Claim 14
Dependent Claim
6 words
A pharmaceutical composition comprising compound L-745,596.
Claim 15
Independent Claim
15 words
A method of treating a patient having cancer comprising administration of L-745,596 to the patient.
Claim 16
Independent Claim
15 words
A method of treating a patient having cancer comprising administration of L-745,596 to the patient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-05-25 | 2001-11-24 | 2002-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-05-25 | 2005-11-24 | 2006-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-05-25 | 2009-11-24 | 2010-05-26 | $7700.00 | Window Closed / Lapsed |