US5753234A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Single-shot vaccine formulation
Assignee: LG Corp
•
Filing: 1996-03-11
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Granted: 1998-05-19
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Expires: 2016-03-11
Abstract
Abstract A microparticle having a particle size ranging from 0.5 to 300 μm, which is prepared by dissolving an antigen or a mixture of antigens in an aqueous solution, adding a water-soluble substance thereto, and removing water to obtain a core particle and coating the core particle with a biodegradable polymer; and a single-shot vaccine formulation prepared by dispersing the microparticles in an injection medium.
Inventors
- 👤 Hyeon-Kook Lee
- 👤 Jung-Hwan Park
- 👤 Nam-Sok Choi
- 👤 Myung-Jin Kim
- 👤 Soo-Hyeon Kim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031; A61K39/00; A61K39/12; A61K2039/555; A61K2039/55511; A61K2039/55555; C; C12; C12N; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10134; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
50 words
A microparticle having a particle size ranging from 0.5 to 300 μm, which is prepared by dissolving an antigen or a mixture of antigens in an aqueous solution, adding a water-soluble substance thereto, and removing water to obtain a core particle and coating the core particle with a biodegradable polymer.
Claim 2
Dependent Claim
50 words
A microparticle having a particle size ranging from 0.5 to 300 μm, which is prepared by dissolving an antigen or a mixture of antigens in an aqueous solution, adding a water-soluble substance thereto, and removing water to obtain a core particle and coating the core particle with a biodegradable polymer.
Claim 3
Dependent Claim
15 words
The microparticle of claim 1, wherein the antigen is an attenuated, killed or recombinant antigen.
Claim 4
Dependent Claim
17 words
The microparticle of claim 1, wherein the core particle further comprises an adjuvant or an inorganic salt.
Claim 5
Dependent Claim
55 words
The microparticle of claim 1, wherein the antigen is obtained from or directed against the pathogen responsible for one or more of diseases selected from the group consisting of: hepatitis, diphtheria, chickenpox, typhoid, pertussis, tetanus, tuberculosis, salmonellosis, cholera, herpes, yellow fever, measles, poliomyelitis, rubella, mumps, rabies, plaque, schistosomiasis, influenza, trypanosomiasis, leishmaniasis, leprosy, meningitis, and malaria.
Claim 6
Dependent Claim
32 words
The microparticle of claim 3, wherein the adjuvant is alum; muramyl dipeptide, muramyl tripeptide and derivatives thereof; tymosin alpha; monophosphoryl lipid A; saponin; an immunostimulating complex; a polyelectrolyte; or a mixture thereof.
Claim 7
Dependent Claim
25 words
The microparticle of claim 1, wherein the water-soluble substance is used in an amount ranging from 1 to 50 times the weight of the antigen.
Claim 8
Dependent Claim
21 words
The microparticle of claim 1, wherein the water-soluble substance is a saccharide, a protein, an amino acid or a mixture thereof.
Claim 9
Dependent Claim
29 words
The microparticle of claim 7, wherein the saccharide is a cellulosic polymer, glucose, xylose, galactose, fructose, lactose, maltose, saccharose, alginate, dextran, hyaluronic acid, chondroitin sulfate or a mixture thereof.
Claim 10
Dependent Claim
23 words
The microparticle of claim 8, wherein the cellulosic polymer is hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose or a mixture thereof.
Claim 11
Dependent Claim
15 words
The microparticle of claim 7, wherein the protein is gelatin, albumin or a mixture thereof.
Claim 12
Dependent Claim
23 words
The microparticle of claim 7, wherein the amino acid is glycine, alanine, glutamic acid, arginine, lysine, or a salt or a mixture thereof.
Claim 13
Dependent Claim
19 words
The microparticle of claim 1, wherein the particle size of the core particle ranges from 0.1 to 200 μm.
Claim 14
Dependent Claim
26 words
The microparticle of claim 1, wherein the biodegradable polymer is used in an amount ranging from 1 to 100 times the weight of the core particle.
Claim 15
Dependent Claim
17 words
The microparticle of claim 1, wherein the biodegradable polymer is polyglycolide, polylactide, poly(lactide-co-glycolide) or a mixture thereof.
Claim 16
Dependent Claim
22 words
The microparticle of claim 1, wherein the biodegradable polymer is copolyoxalate, polycaprolactone, poly(lactide-co-caprolactone), polyesteramide, polyorthoester, poly(β-hydroxybutyric acid), polyanhydride or a mixture thereof.
Claim 17
Dependent Claim
21 words
A single-shot vaccine formulation prepared by dispersing microparticles recited in any one of claims 1 to 15 in an injection medium.
Claim 18
Dependent Claim
23 words
The single-shot vaccine formulation of claim 16, wherein the injection medium is a buffer which optionally contains a dispersing agent and/or a preservative.
Claim 19
Dependent Claim
30 words
The single-shot vaccine formulation of claim 17, wherein the injection medium is an edible oil, mineral oil, cod liver oil, squalene, squalane, mono-, di- or triglyceride, or a mixture thereof.
Claim 20
Dependent Claim
31 words
The single-shot vaccine formulation of claim 18, wherein the edible oil is corn oil, sesame oil, olive oil, soybean oil, safflower oil, cotton seed oil, peanut oil or a mixture thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-05-18 | 2001-11-17 | 2002-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-05-18 | 2005-11-17 | 2006-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-05-18 | 2009-11-17 | 2010-05-19 | $7700.00 | Window Closed / Lapsed |