US4338335A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vaccine stabilizer containing L-glutamic acid and L-arginine
Assignee: Merck and Co Inc
•
Filing: 1980-07-30
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Granted: 1982-07-06
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Expires: 2000-07-30
Abstract
Abstract An improved stabilized liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a monosaccharide or disaccharide, a cell culture medium, L-glutamic acid, L-arginine and sufficient physiologically acceptable acidic buffer to maintain the pH at from about 6.0 to about 6.5.
Inventors
- 👤 William J. McAleer
- 👤 Henry Z. Markus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:15
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/155; A61K39/165; C; C12; C12N; C12N7/00; A61K2039/51; A61K2039/525; A61K2039/5254; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18411; C12N2760/18434; C12N2760/18451; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
97 words
A stabilizer for a liquid vaccine consisting essentially of on a parts by weight basis from about 1.5 to about 2.1 parts partially hydrolyzed gelatin having a molecular weight of about 3,000, from about 7.0 to about 13.0 parts of sorbitol, sucrose, lactose or maltose, from about 0.4 to about 0.6 parts of an in vitro cell culture medium, from about 0.35 to about 0.7 part L-glutamic acid, from about 0.75 to about 1.3 parts L-arginine, and an amount of a physiologically acceptable acidic buffer effective to adjust the pH to from about 6.0 to about 6.5.
Claim 2
Dependent Claim
97 words
A stabilizer for a liquid vaccine consisting essentially of on a parts by weight basis from about 1.5 to about 2.1 parts partially hydrolyzed gelatin having a molecular weight of about 3,000, from about 7.0 to about 13.0 parts of sorbitol, sucrose, lactose or maltose, from about 0.4 to about 0.6 parts of an in vitro cell culture medium, from about 0.35 to about 0.7 part L-glutamic acid, from about 0.75 to about 1.3 parts L-arginine, and an amount of a physiologically acceptable acidic buffer effective to adjust the pH to from about 6.0 to about 6.5.
Claim 3
Dependent Claim
11 words
A stabilizer according to claim 1 wherein the disaccharide is sucrose.
Claim 4
Dependent Claim
77 words
A stabilizer according to claim 1 consisting essentially of on a parts by weight basis of about 1.8 parts partially hydrolyzed gelatin having a molecular weight of about 3,000, about 10 parts of a monosaccharide or disaccharide, about 0.5 part of an in vitro cell culture medium, about 0.5 part L-glutamic acid, about 1.0 part L-arginine, and an amount of a physiologically acceptable acidic buffer effective to adjust the pH to from about 6.0 to about 6.5.
Claim 5
Dependent Claim
11 words
A stabilizer according to claim 3 wherein the disaccharide is sucrose.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-07-05 | 1986-01-04 | 1986-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-05 | 1990-01-04 | 1990-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-05 | 1994-01-04 | 1994-07-06 | $7700.00 | Window Closed / Lapsed |