US4744933A
Expired / Lapsed
US
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Process for encapsulation and encapsulated active material system
Assignee: Massachusetts Institute of Technology
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Filing: 1985-08-16
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Granted: 1988-05-17
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Expires: 2005-08-16
Abstract
Abstract Capsules are formed herein a liquified core while avoiding capsule core gelation by adding drops of a solution of either an anionic polymer composition or a cationic polymer composition to a solution of an ionic polymer of opposite charge. The drops contain an active ingredient such as a cell or microorganism capable of producing a biologically active product or can contain a biological or chemical composition. The interface of the ionic polymers form a permeable membrane surrounding the liquid drops.
Inventors
- 👤 ChoKyun Rha
- 👤 Dolores Rodriguez-Sanchez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/5089; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
182 words
A process for producing a capsule having an aqueous liquid core from ionic polymers while avoiding gelation of the core comprising the steps of: forming an aqueous non-gel liquid droplet from an aqueous solution of a first ionic polymer selected from the group consisting of at least one anionic polymer and at least one cationic polymer, said liquid droplet containing an active material suspended in said droplet; and contacting said aqueous non-gel droplet with an aqueous solution of at least one second ionic polymer, said second ionic polymer having an ionic charge opposite from said first ionic polymer whereby said first and second polymers interact with each other and wherein said first ionic polymer and said second ionic polymer are free to react with each other along the entire chain lengths of said polymers where said polymers come into reactive contact with each other to form a membrane encapsulating said non gel droplets and said active material or aqueous liquid core containing said active material, and said encapsulated non gel droplets being suspended in said aqueous solution of said second ionic polymer.
Claim 2
Dependent Claim
182 words
A process for producing a capsule having an aqueous liquid core from ionic polymers while avoiding gelation of the core comprising the steps of: forming an aqueous non-gel liquid droplet from an aqueous solution of a first ionic polymer selected from the group consisting of at least one anionic polymer and at least one cationic polymer, said liquid droplet containing an active material suspended in said droplet; and contacting said aqueous non-gel droplet with an aqueous solution of at least one second ionic polymer, said second ionic polymer having an ionic charge opposite from said first ionic polymer whereby said first and second polymers interact with each other and wherein said first ionic polymer and said second ionic polymer are free to react with each other along the entire chain lengths of said polymers where said polymers come into reactive contact with each other to form a membrane encapsulating said non gel droplets and said active material or aqueous liquid core containing said active material, and said encapsulated non gel droplets being suspended in said aqueous solution of said second ionic polymer.
Claim 3
Dependent Claim
12 words
The process of claim 1 wherein said active material is a lymphocyte.
Claim 4
Dependent Claim
12 words
The process of claim 1 wherein said active material is a bacteria.
Claim 5
Dependent Claim
14 words
The process of claim 1 wherein said active material is a biologically active compound.
Claim 6
Dependent Claim
11 words
The process of claim 4 wherein said compound is an enzyme.
Claim 7
Dependent Claim
11 words
The process of claim 4 wherein said compound is a hormone.
Claim 8
Dependent Claim
15 words
The process of claim 1 wherein said active material is at least one living cell.
Claim 9
Dependent Claim
11 words
The process of claim 7 wherein said cell is a hybridoma.
Claim 10
Dependent Claim
13 words
The process of claim 1 wherein the said active material is a microorganism.
Claim 11
Dependent Claim
47 words
The process for producing a product for a living cell which comprises encapsulating said cell by the process of claim 1 and controlling the permeability of said membrane to prevent said product from permeating said membrane, collecting said encapsulated cell, rupturing said membrane and recovering said product.
Claim 12
Dependent Claim
11 words
The process of claim 10 wherein said cell is a hybridomia.
Claim 13
Dependent Claim
12 words
The process of claim 10 wherein said cell is a lymphocyte cell.
Claim 14
Dependent Claim
26 words
The process of any one of claims 1, 10, 11 or 12 wherein said anionic polymer is selected from the group consisting of alginate and carragenan.
Claim 15
Dependent Claim
25 words
The process of anyone of claims 1, 10, 11 or 12 wherein said cations polymer is selected from the group consisting of chitosan and polylysine.
References Cited (Backward Citations)
US2800457A
Cited
US3415758A
Cited
US3549555A
Cited
US3629392A
Cited
US3959457A
Cited
US3994827A
Cited
US4001480A
Cited
US4391909A
Cited
US4389330A
Cited
US4407957A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-17 | 1991-11-16 | 1992-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-17 | 1995-11-16 | 1996-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-17 | 1999-11-16 | 2000-05-17 | $7700.00 | Window Closed / Lapsed |