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US5735279A
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SQUID magnetometry using ferro-, ferri- are paramagnetic particles
Assignee: GE Healthcare AS
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Filing: 1995-06-07
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Granted: 1998-04-07
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Expires: 2015-06-07
Abstract
Abstract The invention provides for the use of a physiologically tolerable, particulate, free or matrix-borne, ferromagnetic, ferrimagnetic or paramagnetic material for the manufacture of a diagnostic agent for magnetometric imaging of a human or non-human animal body.
Inventors
- 👤 Jo Klaveness
- 👤 Thorfinn Ege
- 👤 Scott M. Rocklage
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:42
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; A61K49/1887; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1851; A61K49/1857; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
63 words
A method of generating a magnetometric image of a human or non-human animal body which method comprises administering into the gastrointestinal tract, the reproductive tract, the urinary tract, a closed body cavity or the musculature of said body physiologically tolerable lipid-coated ferromagnetic or ferrimagnetic particles and generating a magnetometric image of at least a part of said body into which said particles distribute.
Claim 2
Independent Claim
63 words
A method of generating a magnetometric image of a human or non-human animal body which method comprises administering into the gastrointestinal tract, the reproductive tract, the urinary tract, a closed body cavity or the musculature of said body physiologically tolerable lipid-coated ferromagnetic or ferrimagnetic particles and generating a magnetometric image of at least a part of said body into which said particles distribute.
Claim 3
Dependent Claim
37 words
A method as claimed in claim 1 wherein said step of generating a magnetometric image comprises detecting magnetic field perturbations within said body using a SQUID-based magnetometer and generating a two- or three-dimensional image of said body.
Claim 4
Dependent Claim
25 words
A method as claimed in claim 2 wherein in an additional step a magnetic resonance image of said body is generated as a reference image.
Claim 5
Dependent Claim
25 words
A method as claimed in claim 1 wherein in an additional step a magnetic resonance image of said body is generated as a reference image.
Claim 6
Independent Claim
43 words
A method of generating a magnetometric image of a lymph node of a human or non-human animal body which method comprises administering into the lymph node physiologically tolerable dextran-coated paramagnetic, ferromagnetic or ferrimagnetic particles and generating a magnetometric image of said lymph node.
Claim 7
Independent Claim
43 words
A method of generating a magnetometric image of a lymph node of a human or non-human animal body which method comprises administering into the lymph node physiologically tolerable dextran-coated paramagnetic, ferromagnetic or ferrimagnetic particles and generating a magnetometric image of said lymph node.
Claim 8
Dependent Claim
39 words
A method as claimed in claim 5 wherein said step of generating a magnetometric image comprises detecting magnetic field perturbations within said lymph nodes using a SQUID-based magnetometer and generating a two- or three-dimensional image of said lymph node.
Claim 9
Dependent Claim
26 words
A method as claimed in claim 6 wherein in an additional step a magnetic resonance image of said lymph node is generated as a reference image.
Claim 10
Dependent Claim
26 words
A method as claimed in claim 5 wherein in an additional step a magnetic resonance image of said lymph node is generated as a reference image.
Claim 11
Independent Claim
44 words
A method of generating a magnetometric image of an axonal system of a human or non-human animal body which method comprises administering into the axonal system physiologically tolerable nerve-adhesion molecule-labelled paramagnetic, ferromagnetic or ferrimagnetic particles and generating a magnetometric image of said axonal system.
Claim 12
Independent Claim
44 words
A method of generating a magnetometric image of an axonal system of a human or non-human animal body which method comprises administering into the axonal system physiologically tolerable nerve-adhesion molecule-labelled paramagnetic, ferromagnetic or ferrimagnetic particles and generating a magnetometric image of said axonal system.
Claim 13
Dependent Claim
39 words
A method as claimed in claim 9 wherein said step of generating a magnetometric image comprises detecting magnetic field perturbations within said axonal system using a SQUID-based magnetometer and generating a two- or three-dimensional image of said axonal system.
Claim 14
Dependent Claim
26 words
A method as claimed in claim 10 wherein in an additional step a magnetic resonance image of said axonal system is generated as a reference image.
Claim 15
Dependent Claim
26 words
A method as claimed in claim 9 wherein in an additional step a magnetic resonance image of said axonal system is generated as a reference image.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-06 | 2001-10-06 | 2002-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-06 | 2005-10-06 | 2006-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-06 | 2009-10-06 | 2010-04-07 | $7700.00 | Window Closed / Lapsed |