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US5715835A
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Methods for treating and reducing the potential for cardiovascular disease using methioninase compositions
Assignee: Anticancer Inc
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Filing: 1995-06-07
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Granted: 1998-02-10
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Expires: 2015-06-07
Abstract
Abstract The present invention provides methods for treating and reducing the potential for cardiovascular disease using methioninase compositions having less than 10 ng endotoxin per mg methioninase.
Inventors
- 👤 Valeryi Lishko
- 👤 Yuying Tan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:46
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/51; A61K31/00; A61K31/33; A61K31/335; A61K31/337; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K48/00; A61P; A61P35/00; C; C12; C12N; C12N9/00; C12N9/88
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
38 words
A method for lowering homocysteine levels in a patient comprising the step of administering to said patient a therapeutically effective amount of a methioninase composition wherein said methioninase composition contains less than 10 ng endotoxin per mg methioninase.
Claim 2
Independent Claim
38 words
A method for lowering homocysteine levels in a patient comprising the step of administering to said patient a therapeutically effective amount of a methioninase composition wherein said methioninase composition contains less than 10 ng endotoxin per mg methioninase.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein said lowering of said homocysteine levels is used to treat cardiovascular disease.
Claim 4
Dependent Claim
11 words
The method of claim 2 wherein said cardiovascular disease is arteriosclerosis.
Claim 5
Dependent Claim
13 words
The method of claim 3 wherein said methioninase is conjugated to a polymer.
Claim 6
Dependent Claim
11 words
The method of claim 4 wherein said polymer is polyethylene glycol.
Claim 7
Dependent Claim
13 words
The method of claim 2 wherein said methioninase is conjugated to a polymer.
Claim 8
Dependent Claim
11 words
The method of claim 6 wherein said polymer is polyethylene glycol.
Claim 9
Dependent Claim
21 words
The method of claim 1 wherein said lowering of said homocysteine levels is used to reduce the potential of cardiovascular disease.
Claim 10
Dependent Claim
11 words
The method of claim 8 wherein said cardiovascular disease is arteriosclerosis.
Claim 11
Dependent Claim
13 words
The method of claim 8 wherein said methioninase is conjugated to a polymer.
Claim 12
Dependent Claim
11 words
The method of claim 10 wherein said polymer is polyethylene glycol.
Claim 13
Dependent Claim
13 words
The method of claim 1 wherein said methioninase is conjugated to a polymer.
Claim 14
Dependent Claim
11 words
The method of claim 12 wherein said polymer is polyethylene glycol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-02-09 | 2001-08-11 | 2002-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-02-09 | 2005-08-11 | 2006-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-02-09 | 2009-08-11 | 2010-02-10 | $7700.00 | Window Closed / Lapsed |