US5707352A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pulmonary delivery of therapeutic agent
Assignee: Temple University
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Filing: 1995-06-07
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Granted: 1998-01-13
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Expires: 2015-06-07
Abstract
Abstract An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
Inventors
- 👤 K. Michael Sekins
- 👤 Thomas H. Shaffer
- 👤 Marla R. Wolfson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:17
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61F; A61F7/00; A61F7/12; A61F7/123; A61M; A61M16/00; A61M16/04; A61M16/0402; A61M16/0404; A61M16/0434; A61M16/0454; A61M16/0459; A61M16/0463; A61M16/0475; A61M16/0477; A61M16/0479; A61M16/0486; A61N; A61N7/00; A61N7/02; A61N7/022; B; B06; B06B; B06B1/00; B06B1/02; B06B1/06; B06B1/0607; B06B1/0622; B06B1/0633; A61B; A61B17/00; A61B17/22; A61B2017/22051; A61B2017/22054; A61B18/00; A61B2018/00005; A61B2018/00011; A61F2007/0054; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/33; A61M2205/3368; Y; Y10; Y10S; Y10S128/00; Y10S128/913; Y10T; Y10T137/00; Y10T137/8593; Y10T137/87571; Y10T137/87652
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
55 words
A process for controlling, diagnosing or treating physiological conditions, diseases or abnormalities of a patient, said process comprising: providing a liquid medium comprising at least one solid or liquid therapeutic or diagnostic agent distributed in a breathable liquid carrier; and passing said liquid medium through at least a portion of said patient's pulmonary air passages.
Claim 2
Dependent Claim
55 words
A process for controlling, diagnosing or treating physiological conditions, diseases or abnormalities of a patient, said process comprising: providing a liquid medium comprising at least one solid or liquid therapeutic or diagnostic agent distributed in a breathable liquid carrier; and passing said liquid medium through at least a portion of said patient's pulmonary air passages.
Claim 3
Dependent Claim
19 words
A process according to claim 1 further comprising the step of selecting a patient suffering from respiratory distress syndrome.
Claim 4
Dependent Claim
40 words
A process according to claim 1 further comprising selecting said therapeutic or diagnostic agent from the group consisting of, antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents and combinations thereof.
Claim 5
Dependent Claim
34 words
A process according to claim 1 further comprising distributing said therapeutic or diagnostic agent in a form selected from the group consisting of a suspension, a dispersion, an encapsulation, an emulsion and combinations thereof.
Claim 6
Dependent Claim
19 words
A process according to claim 1 further comprising the step of removing said liquid medium from said pulmonary passages.
Claim 7
Dependent Claim
15 words
A process according to claim 1 further comprising selecting a powdered therapeutic or diagnostic agent.
Claim 8
Dependent Claim
22 words
A process according to claim 1 further comprising the step of heating said liquid medium above the body temperature of the patient.
Claim 9
Dependent Claim
28 words
A process according to claim 1 further comprising selecting said breathable liquid carrier from the group consisting of fluorocarbon liquids, saline, silicone liquids, vegetable oils and combinations thereof.
Claim 10
Dependent Claim
32 words
A process according to claim 8 further comprising selecting a breathable liquid carrier comprising a perfluorocarbon characterized by an average molecular weight in the range of from about 350 to about 560.
Claim 11
Dependent Claim
19 words
A process according to claim 8 further comprising the step of selecting a breathable liquid carrier comprising a fluorocarbon.
Claim 12
Independent Claim
78 words
A method for performing liquid lavage to control, diagnose or treat physiological conditions, diseases or abnormalities of a patient, said method comprising the steps of: providing a liquid medium comprising at least one solid or liquid therapeutic or diagnostic agent distributed in a breathable liquid carrier; delivering said liquid medium into at least a portion of the patient's pulmonary air passages; and removing the liquid medium from said at least a portion of the patient's pulmonary air passages.
Claim 13
Independent Claim
78 words
A method for performing liquid lavage to control, diagnose or treat physiological conditions, diseases or abnormalities of a patient, said method comprising the steps of: providing a liquid medium comprising at least one solid or liquid therapeutic or diagnostic agent distributed in a breathable liquid carrier; delivering said liquid medium into at least a portion of the patient's pulmonary air passages; and removing the liquid medium from said at least a portion of the patient's pulmonary air passages.
Claim 14
Dependent Claim
41 words
A method according to claim 11 further comprising selecting said therapeutic or diagnostic agent from the group consisting of toxins, antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents and combinations thereof.
Claim 15
Dependent Claim
34 words
A method according to claim 11 further comprising distributing said therapeutic or diagnostic agent in a form selected from the group consisting of a suspension, a dispersion, an encapsulation, an emulsion and combinations thereof.
Claim 16
Dependent Claim
28 words
A method according to claim 11 further comprising selecting said breathable liquid carrier from the group consisting of fluorocarbon liquids, saline, silicone liquids, vegetable oils and combinations thereof.
Claim 17
Independent Claim
83 words
A method for performing liquid ventilation to control, diagnose or treat physiological conditions, diseases or abnormalities of a patient, said method comprising the steps of: dispersing a solid or liquid therapeutic or diagnostic agent in a fluorocarbon liquid to provide a bioactive liquid medium; administering said bioactive liquid medium into at least a portion of the patient's pulmonary air passages; and introducing a breathing gas into said at least a portion of the patient's pulmonary air passages whereby pulmonary gas exchange is maintained.
Claim 18
Independent Claim
83 words
A method for performing liquid ventilation to control, diagnose or treat physiological conditions, diseases or abnormalities of a patient, said method comprising the steps of: dispersing a solid or liquid therapeutic or diagnostic agent in a fluorocarbon liquid to provide a bioactive liquid medium; administering said bioactive liquid medium into at least a portion of the patient's pulmonary air passages; and introducing a breathing gas into said at least a portion of the patient's pulmonary air passages whereby pulmonary gas exchange is maintained.
Claim 19
Dependent Claim
41 words
A method according to claim 15 further comprising selecting said therapeutic or diagnostic agent from the group consisting of toxins, antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents and combinations thereof.
Claim 20
Dependent Claim
32 words
A method according to claim 15 further comprising dispersing said therapeutic or diagnostic agent in a form selected from the group consisting of a suspension, an encapsulation, an emulsion and combinations thereof.
Claim 21
Dependent Claim
15 words
A method according to claim 15 further comprising selecting a powdered therapeutic or diagnostic agent.
Claim 22
Dependent Claim
27 words
A method according to claim 15 further comprising selecting a fluorocarbon characterized by an average molecular weight in the range of from about 350 to about 560.
References Cited (Backward Citations)
FR2214467A1
Cited
US3911138A
Cited
US3911138B1
Cited
US4233984A
Cited
DE2848636A1
Cited
US4232665A
Cited
EP0074809A1
Cited
US4740103A
Cited
WO1984000686A1
Cited
EP0118850A2
Cited
US4669463A
Cited
WO1986002845A1
Cited
US4657532A
Cited
US4881542A
Cited
US4886496A
Cited
USRE34077E
Cited
US5177062A
Cited
US4933169A
Cited
US4955375A
Cited
US4976261A
Cited
US5031613A
Cited
US5158536A
Cited
US5135490A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-12 | 2001-07-14 | 2002-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-12 | 2005-07-14 | 2006-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-12 | 2009-07-14 | 2010-01-13 | $7700.00 | Window Closed / Lapsed |