US5678570A
Expired / Lapsed
US
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Method of treating cardiac arrest
Assignee: University of North Carolina at Chapel Hill
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Filing: 1995-04-14
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Granted: 1997-10-21
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Expires: 2015-04-14
Abstract
Abstract A method of treating a subject under cardiac arrest comprises the steps of: blocking the descending aorta of the subject; then withdrawing blood from the subject; oxygenating the blood withdrawn from the subject; and perfusing the aortic arch of the subject with oxygenated blood in an amount effective to deliver oxygen to the heart of the subject. This method enables the subject to continue to receive oxygenating material (i.e., blood in this instance) without the danger of volume overload that would be present if another oxygenated solution were continuously infused.
Inventors
- 👤 James E. Manning
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:00
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3601; A61M1/3603; A61M1/3613; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/20; A61M60/247; A61M60/253; A61M60/268; A61M60/279; A61M60/30; A61M60/36; A61M60/38; A61M60/40; A61M60/424; A61M60/438; A61M60/441; A61M60/443; A61M60/50; A61M60/508; A61M60/515; A61M60/562; A61M60/80; A61M60/802; A61M60/833; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
50 words
An apparatus for treating a subject in cardiac arrest, comprising: means for perfusing the aorta of the subject with a heterologous protective solution; means for withdrawing autologous blood from the subject; means for oxygenating the autologous blood; means for perfusing the aorta of the subject with the oxygenated autologous blood.
Claim 2
Independent Claim
50 words
An apparatus for treating a subject in cardiac arrest, comprising: means for perfusing the aorta of the subject with a heterologous protective solution; means for withdrawing autologous blood from the subject; means for oxygenating the autologous blood; means for perfusing the aorta of the subject with the oxygenated autologous blood.
Claim 3
Dependent Claim
16 words
The apparatus of claim 1, further comprising means for introducing an anticoagulant to the autologous blood.
Claim 4
Dependent Claim
25 words
The apparatus of claim 2, wherein said anticoagulant-introducing means is configured to introduce anticoagulant to autologous blood as the autologous blood enters said withdrawing means.
Claim 5
Dependent Claim
17 words
The apparatus of claim 1, further comprising means for perfusing the autologous blood in a pulsatile rhythm.
Claim 6
Dependent Claim
46 words
The apparatus of claim 1, wherein said means for perfusing with heterologous protective solution comprises a first catheter, and said means for perfusing with said autologous blood comprises said first catheter, said first catheter having an outlet configured for positioning within the aorta of said subject.
Claim 7
Dependent Claim
27 words
The apparatus of claim 5, further comprising means for oxygenating the heterologous solution prior to the perfusion of the aorta of said subject with said heterologous solution.
Claim 8
Dependent Claim
37 words
The apparatus of claim 4, wherein said withdrawing means comprises a second catheter, said second catheter extending parallel with and adjacent to said first catheter and having an outlet downstream from said outlet of said first catheter.
Claim 9
Independent Claim
84 words
A method of treating a subject in cardiac arrest, comprising the steps of: blocking the descending aorta of said subject; then withdrawing autologous blood from said subject; oxygenating said autologous blood; then perfusing the aortic arch of said subject with an oxygenated heterologous protective solution in an amount effective to deliver oxygen to the heart of said subject; and then perfusing the aortic arch of said subject with oxygenated autologous blood in an amount effective to deliver oxygen to the heart of said subject.
Claim 10
Independent Claim
84 words
A method of treating a subject in cardiac arrest, comprising the steps of: blocking the descending aorta of said subject; then withdrawing autologous blood from said subject; oxygenating said autologous blood; then perfusing the aortic arch of said subject with an oxygenated heterologous protective solution in an amount effective to deliver oxygen to the heart of said subject; and then perfusing the aortic arch of said subject with oxygenated autologous blood in an amount effective to deliver oxygen to the heart of said subject.
Claim 11
Dependent Claim
31 words
The method of claim 8, wherein in said step of perfusing with heterologous protective solution, the heterologous protective solution is infused in an amount such that pulmonary oxygenation is generally unaffected.
Claim 12
Dependent Claim
32 words
The method of claim 9, wherein said withdrawing step is performed after between about 250 and 3000 milliliters of said protective solution has been infused into the aortic arch of said subject.
Claim 13
Dependent Claim
45 words
The method of claim 8, wherein said blocking step comprises the steps of: inserting a balloon catheter into a femoral artery of said subject; then advancing said balloon catheter within the vasculature of said subject to a position within the descending aorta of said subject.
Claim 14
Dependent Claim
28 words
The method of claim 8, wherein said withdrawing step comprises withdrawing blood from a femoral vein of said subject, said femoral vein being adjacent to said femoral artery.
Claim 15
Dependent Claim
52 words
The method of claim 8, wherein said step of perfusing said aorta with protective solution comprises infusing the aorta of said subject with protective solution through a first catheter, and wherein said step of perfusing with autologous blood comprises infusing the aorta of said subject with oxygenated blood through said first catheter.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-10-20 | 2001-04-21 | 2001-10-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-10-20 | 2005-04-21 | 2005-10-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-10-20 | 2009-04-21 | 2009-10-21 | $7700.00 | Window Closed / Lapsed |